CLCN7_HUMAN - dbPTM
CLCN7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLCN7_HUMAN
UniProt AC P51798
Protein Name H(+)/Cl(-) exchange transporter 7
Gene Name CLCN7
Organism Homo sapiens (Human).
Sequence Length 805
Subcellular Localization Lysosome membrane
Multi-pass membrane protein .
Protein Description Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen..
Protein Sequence MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MANVSKKVSWSG
---CCCCCCCCCCCC		26.9426074081
6Ubiquitination--MANVSKKVSWSGR
--CCCCCCCCCCCCC		53.57-
7Ubiquitination-MANVSKKVSWSGRD
-CCCCCCCCCCCCCC		33.7127667366
9PhosphorylationANVSKKVSWSGRDRD
CCCCCCCCCCCCCCC		25.1421712546
11PhosphorylationVSKKVSWSGRDRDDE
CCCCCCCCCCCCCHH		19.2225159151
27PhosphorylationAAPLLRRTARPGGGT
HHHHHHHHCCCCCCC		22.1527251275
30UbiquitinationLLRRTARPGGGTPLL
HHHHHCCCCCCCCCC		43.2321890473
34PhosphorylationTARPGGGTPLLNGAG
HCCCCCCCCCCCCCC		17.6529255136
35UbiquitinationARPGGGTPLLNGAGP
CCCCCCCCCCCCCCC		37.8222817900
48PhosphorylationGPGAARQSPRSALFR
CCCHHHCCCCHHHHH		19.4122617229
60PhosphorylationLFRVGHMSSVELDDE
HHHCCCCCCCCCCHH		26.0929255136
61PhosphorylationFRVGHMSSVELDDEL
HHCCCCCCCCCCHHH		16.4329255136
64UbiquitinationGHMSSVELDDELLDP
CCCCCCCCCHHHCCC		10.6233845483
69UbiquitinationVELDDELLDPDMDPP
CCCCHHHCCCCCCCC		9.3922817900
81UbiquitinationDPPHPFPKEIPHNEK
CCCCCCCCCCCCCHH		69.5229967540
88UbiquitinationKEIPHNEKLLSLKYE
CCCCCCHHHHHCEEE		61.1121890473
88UbiquitinationKEIPHNEKLLSLKYE
CCCCCCHHHHHCEEE		61.1121890473
88UbiquitinationKEIPHNEKLLSLKYE
CCCCCCHHHHHCEEE		61.1122817900
91PhosphorylationPHNEKLLSLKYESLD
CCCHHHHHCEEECCC		33.0024719451
93SumoylationNEKLLSLKYESLDYD
CHHHHHCEEECCCCC		43.53-
93UbiquitinationNEKLLSLKYESLDYD
CHHHHHCEEECCCCC		43.5322817900
94PhosphorylationEKLLSLKYESLDYDN
HHHHHCEEECCCCCC		18.9522210691
96PhosphorylationLLSLKYESLDYDNSE
HHHCEEECCCCCCCC		24.3726657352
99PhosphorylationLKYESLDYDNSENQL
CEEECCCCCCCCCCE		23.47-
102PhosphorylationESLDYDNSENQLFLE
ECCCCCCCCCCEEEH		34.7222210691
136UbiquitinationICALIGILTGLVACF
HHHHHHHHHHHHHHH		2.3429967540
137PhosphorylationCALIGILTGLVACFI
HHHHHHHHHHHHHHH		26.92-
160UbiquitinationGLKYRVIKGNIDKFT
CCCEEEEECCHHHHH		42.9429967540
1602-HydroxyisobutyrylationGLKYRVIKGNIDKFT
CCCEEEEECCHHHHH		42.94-
212UbiquitinationGIPQIKCFLNGVKIP
CCCCEEEHHCCCCCC		5.1522817900
216UbiquitinationIKCFLNGVKIPHVVR
EEEHHCCCCCCCEEE		5.0321890473
237PhosphorylationKVSGVILSVVGGLAV
EECHHHHHHHCCCCC		12.0223186163
246UbiquitinationVGGLAVGKEGPMIHS
HCCCCCCCCCCCCCC		53.5522817900
250UbiquitinationAVGKEGPMIHSGSVI
CCCCCCCCCCCCCEE		6.7321963094
270UbiquitinationQGRSTSLKRDFKIFE
CCCCCCCCHHHHHHH		50.0822817900
274UbiquitinationTSLKRDFKIFEYFRR
CCCCHHHHHHHHHCC		51.2621890473
274UbiquitinationTSLKRDFKIFEYFRR
CCCCHHHHHHHHHCC		51.2621890473
274UbiquitinationTSLKRDFKIFEYFRR
CCCCHHHHHHHHHCC		51.2621963094
278PhosphorylationRDFKIFEYFRRDTEK
HHHHHHHHHCCCCCC		7.52-
563PhosphorylationLGGIVRMTLSLTVIM
HCHHHHHHEEEEEEE		11.5722210691
565PhosphorylationGIVRMTLSLTVIMME
HHHHHHEEEEEEEHH		16.9022210691
567PhosphorylationVRMTLSLTVIMMEAT
HHHHEEEEEEEHHCC		12.4722210691
575PhosphorylationVIMMEATSNVTYGFP
EEEHHCCCCCCCCCH		36.0322210691
578PhosphorylationMEATSNVTYGFPIML
HHCCCCCCCCCHHHH		23.3722210691
579PhosphorylationEATSNVTYGFPIMLV
HCCCCCCCCCHHHHH		16.7022210691
589PhosphorylationPIMLVLMTAKIVGDV
HHHHHHHHCHHHHHH		22.1924719451
632PhosphorylationLTAREVMSTPVTCLR
CCHHHHHCCCCHHHH		34.4325850435
633PhosphorylationTAREVMSTPVTCLRR
CHHHHHCCCCHHHHH		12.0425850435
636PhosphorylationEVMSTPVTCLRRREK
HHHCCCCHHHHHHHC		13.6625850435
682PhosphorylationLQGLILRSQLIVLLK
HHHHHHHHHHHHHHH		26.37-
701UbiquitinationVERSNLGLVQRRLRL
HCCCCHHHHHHHHHH		3.1421890473
735UbiquitinationQDERECTMDLSEFMN
CCCCEEEECHHHHCC		8.0421890473
744PhosphorylationLSEFMNPSPYTVPQE
HHHHCCCCCCCCCCC		26.0728111955
746PhosphorylationEFMNPSPYTVPQEAS
HHCCCCCCCCCCCCC		25.3828111955
747PhosphorylationFMNPSPYTVPQEASL
HCCCCCCCCCCCCCH		29.1528111955
753PhosphorylationYTVPQEASLPRVFKL
CCCCCCCCHHHHHHH		37.8524719451
759UbiquitinationASLPRVFKLFRALGL
CCHHHHHHHHHHHCC		43.8121890473
783PhosphorylationNQVVGLVTRKDLARY
CCEEEEEEHHHHHHH		36.7222468782
790PhosphorylationTRKDLARYRLGKRGL
EHHHHHHHHCCHHCH		12.4625219547
801PhosphorylationKRGLEELSLAQT---
HHCHHHHHCCCC---		25.5730266825
805PhosphorylationEELSLAQT-------
HHHHCCCC-------		34.6630266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLCN7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLCN7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLCN7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CLCN7_HUMAN !!
Drug and Disease Associations
Kegg Disease
H00436 Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermed
OMIM Disease
611490Osteopetrosis, autosomal recessive 4 (OPTB4)
166600Osteopetrosis, autosomal dominant 2 (OPTA2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLCN7_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-60 AND SER-61,AND MASS SPECTROMETRY.

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