RN167_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN167_HUMAN
• UniProt AC: Q9H6Y7
• Protein Name: E3 ubiquitin-protein ligase RNF167
• Gene Name: RNF167
• Organism: Homo sapiens (Human).
• Sequence Length: 350
• Subcellular Localization: Endomembrane system ; Single-pass membrane protein . Targeted to cytoplasmic membranes.
• Protein Description: May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition..
• Protein Sequence: MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	N-linked_Glycosylation	PPPPAPVNGSVFIAL CCCCCCCCHHHHHHH	35.64	UniProtKB CARBOHYD
97	Ubiquitination	FDCNFDLKVLNAQKA CCCCCEEEECCHHHC	46.66	21890473
156	2-Hydroxyisobutyrylation	RALFVYEKGARVLLV HHHEEEECCCEEEEC	39.94	-
156	Ubiquitination	RALFVYEKGARVLLV HHHEEEECCCEEEEC	39.94	21890473
210	Ubiquitination	LQRNRLTKEQLKQIP HHHCCCCHHHHHCCC	48.32	21890473
214	Ubiquitination	RLTKEQLKQIPTHDY CCCHHHHHCCCCCCC	45.97	21890473
223	Ubiquitination	IPTHDYQKGDQYDVC CCCCCCCCCCCCCEE	59.22	-
237	Phosphorylation	CAICLDEYEDGDKLR EEEEEEECCCCCEEE	20.98	-
242	Ubiquitination	DEYEDGDKLRVLPCA EECCCCCEEEEEECH	43.66	-
266	Ubiquitination	PWLTQTRKTCPICKQ HHHCCCCCCCCCCCC	58.84	-
272	Ubiquitination	RKTCPICKQPVHRGP CCCCCCCCCCCCCCC	59.36	21890473
277	Methylation	ICKQPVHRGPGDEDQ CCCCCCCCCCCCCCH	53.92	115491395
288	Phosphorylation	DEDQEEETQGQEEGD CCCHHHHHCCCCCCC	41.08	-
305	Phosphorylation	EPRDHPASERTPLLG CCCCCCCHHCCCCCC	31.87	20068231
308	Phosphorylation	DHPASERTPLLGSSP CCCCHHCCCCCCCCC	17.78	20873877
313	Phosphorylation	ERTPLLGSSPTLPTS HCCCCCCCCCCCCCC	32.87	20068231
314	Phosphorylation	RTPLLGSSPTLPTSF CCCCCCCCCCCCCCC	21.80	20068231
316	Phosphorylation	PLLGSSPTLPTSFGS CCCCCCCCCCCCCCC	47.52	20873877
319	Phosphorylation	GSSPTLPTSFGSLAP CCCCCCCCCCCCCCC	39.54	20873877
320	Phosphorylation	SSPTLPTSFGSLAPA CCCCCCCCCCCCCCC	26.18	20068231
323	Phosphorylation	TLPTSFGSLAPAPLV CCCCCCCCCCCCCEE	21.24	28348404
335	Phosphorylation	PLVFPGPSTDPPLSP CEECCCCCCCCCCCC	51.89	20873877
336	Phosphorylation	LVFPGPSTDPPLSPP EECCCCCCCCCCCCC	56.51	20068231
341	Phosphorylation	PSTDPPLSPPSSPVI CCCCCCCCCCCCCEE	40.30	20068231
344	Phosphorylation	DPPLSPPSSPVILV- CCCCCCCCCCEEEC-	51.13	20873877
345	Phosphorylation	PPLSPPSSPVILV-- CCCCCCCCCEEEC--	29.03	20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN167_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN167_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN167_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAP26_HUMAN	CCDC59	physical	17353931
RN167_HUMAN	RNF167	physical	16314844
UB2D1_HUMAN	UBE2D1	physical	16314844
UB2E1_HUMAN	UBE2E1	physical	16314844
S22AI_HUMAN	SLC22A18	physical	16314844
RN167_HUMAN	RNF167	physical	24387786

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.