S22AI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S22AI_HUMAN
• UniProt AC: Q96BI1
• Protein Name: Solute carrier family 22 member 18
• Gene Name: SLC22A18
• Organism: Homo sapiens (Human).
• Sequence Length: 424
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Localized at the apical membrane surface of renal proximal tubules.
• Protein Description: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney..
• Protein Sequence: MQGARAPRDQGRSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRKDKVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
210	Ubiquitination	PASTKGAKTDAQAPL CCCCCCCCCCCCCCC	56.45	21906983
224	Phosphorylation	LPGGPRASVFDLKAI CCCCCCCCHHCHHHH	25.29	23312004
229	Ubiquitination	RASVFDLKAIASLLR CCCHHCHHHHHHHCC	39.32	21890473
233	Phosphorylation	FDLKAIASLLRLPDV HCHHHHHHHCCCCCC	23.09	23403867
295	Ubiquitination	MVTQGLVIGQLSSHF HHHHCCHHHHHHCCC	3.32	-
309	Phosphorylation	FSEEVLLRASVLVFI CCHHHHHHHHHHHHH	22.21	-
314	Ubiquitination	LLRASVLVFIVVGLA HHHHHHHHHHHHHHH	2.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF167	Q9H6Y7	PMID:16314844

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S22AI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S22AI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RN167_HUMAN	RNF167	physical	16314844

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 211980: Lung cancer (LNCR)
• 268210: Rhabdomyosarcoma, embryonal, 1 (RMSE1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.