dbPTM

TF2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TF2B_HUMAN
UniProt AC	Q00403
Protein Name	Transcription initiation factor IIB
Gene Name	GTF2B
Organism	Homo sapiens (Human).
Sequence Length	316
Subcellular Localization	Nucleus.
Protein Description	General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II..
Protein Sequence	MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASTSRLDAL -----CCCCCCCCCC	26.14	23186163
4	Phosphorylation	----MASTSRLDALP ----CCCCCCCCCCC	14.34	23186163
5	Phosphorylation	---MASTSRLDALPR ---CCCCCCCCCCCC	28.49	23186163
27	Phosphorylation	DAILVEDYRAGDMIC CEEEECCCCCCCEEC	6.72	21214269
32	Sulfoxidation	EDYRAGDMICPECGL CCCCCCCEECCCCCC	3.12	21406390
55	Ubiquitination	VGSEWRTFSNDKATK CCCCCEECCCCCCCC	4.88	22817900
59	Ubiquitination	WRTFSNDKATKDPSR CEECCCCCCCCCHHH	63.31	29967540
65	Phosphorylation	DKATKDPSRVGDSQN CCCCCCHHHCCCCCC	50.13	23090842
69	Ubiquitination	KDPSRVGDSQNPLLS CCHHHCCCCCCCCCC	44.16	21890473
70	Phosphorylation	DPSRVGDSQNPLLSD CHHHCCCCCCCCCCC	26.40	21712546
76	Phosphorylation	DSQNPLLSDGDLSTM CCCCCCCCCCCHHHH	47.43	25159151
81	Phosphorylation	LLSDGDLSTMIGKGT CCCCCCHHHHCCCCC	22.22	28464451
82	Phosphorylation	LSDGDLSTMIGKGTG CCCCCHHHHCCCCCC	21.80	29116813
83	Sulfoxidation	SDGDLSTMIGKGTGA CCCCHHHHCCCCCCC	3.23	21406390
86	Ubiquitination	DLSTMIGKGTGAASF CHHHHCCCCCCCCCH	42.23	21906983
88	Ubiquitination	STMIGKGTGAASFDE HHHCCCCCCCCCHHH	27.42	23000965
88	Phosphorylation	STMIGKGTGAASFDE HHHCCCCCCCCCHHH	27.42	27251275
92	Phosphorylation	GKGTGAASFDEFGNS CCCCCCCCHHHCCCC	32.47	25159151
100	Ubiquitination	FDEFGNSKYQNRRTM HHHCCCCHHCCCCCC	55.65	23000965
100	Acetylation	FDEFGNSKYQNRRTM HHHCCCCHHCCCCCC	55.65	25953088
109	Phosphorylation	QNRRTMSSSDRAMMN CCCCCCCHHHHHHHH	25.99	22210691
110	Phosphorylation	NRRTMSSSDRAMMNA CCCCCCHHHHHHHHH	24.65	22210691
112	Ubiquitination	RTMSSSDRAMMNAFK CCCCHHHHHHHHHHH	26.74	21890473
119	Ubiquitination	RAMMNAFKEITTMAD HHHHHHHHHHHHHHH	45.88	23000965
123	Phosphorylation	NAFKEITTMADRINL HHHHHHHHHHHHCCC	18.94	-
127	Methylation	EITTMADRINLPRNI HHHHHHHHCCCCHHH	15.34	-
143	Ubiquitination	DRTNNLFKQVYEQKS HHHHHHHHHHHHHHC	41.86	21906983
147	Ubiquitination	NLFKQVYEQKSLKGR HHHHHHHHHHCCCCC	53.31	23000965
149	Ubiquitination	FKQVYEQKSLKGRAN HHHHHHHHCCCCCHH	45.90	33845483
178	Ubiquitination	EGVPRTFKEICAVSR CCCCCCHHHHHHHHC	45.62	23000965
178	Acetylation	EGVPRTFKEICAVSR CCCCCCHHHHHHHHC	45.62	25953088
196	Acetylation	KEIGRCFKLILKALE HHHHHHHHHHHHHHH	37.94	25953088
238	Ubiquitination	AATHIARKAVELDLV HHHHHHHHHHHCCCC	48.00	12931194
238	Acetylation	AATHIARKAVELDLV HHHHHHHHHHHCCCC	48.00	12931194
249	Phosphorylation	LDLVPGRSPISVAAA CCCCCCCCHHHHHHH	32.28	25159151
252	Phosphorylation	VPGRSPISVAAAAIY CCCCCHHHHHHHHHH	14.75	25627689
270	Phosphorylation	QASAEKRTQKEIGDI HHHHHHHHHHHHHHH	55.87	-
272	Ubiquitination	SAEKRTQKEIGDIAG HHHHHHHHHHHHHHC	51.16	-
274	Ubiquitination	EKRTQKEIGDIAGVA HHHHHHHHHHHHCCC	8.49	22817900
281	Ubiquitination	IGDIAGVADVTIRQS HHHHHCCCCEEEEEE	12.49	24816145
284	Phosphorylation	IAGVADVTIRQSYRL HHCCCCEEEEEEEEE	15.81	-
293	Phosphorylation	RQSYRLIYPRAPDLF EEEEEEECCCCCCCC	7.40	22817900
305	Ubiquitination	DLFPTDFKFDTPVDK CCCCCCCCCCCCHHH	45.18	22817900
312	Ubiquitination	KFDTPVDKLPQL--- CCCCCHHHCCCC---	63.40	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TF2B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
238	K	Acetylation		12931194
Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TF2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_HUMAN	TBP	physical	9159119
TAF11_HUMAN	TAF11	physical	9159119
TF2H4_HUMAN	GTF2H4	physical	9159119
JUN_HUMAN	JUN	physical	7848298
T2FB_HUMAN	GTF2F2	physical	8662660
T2FA_HUMAN	GTF2F1	physical	8662660
REL_HUMAN	REL	physical	8413269
RPC1_HUMAN	POLR3A	physical	11416169
PKP2_HUMAN	PKP2	physical	11416169
STF1_HUMAN	NR5A1	physical	10478848
T2EB_HUMAN	GTF2E2	physical	11113176
KLF5_HUMAN	KLF5	physical	9089417
RPB1_HUMAN	POLR2A	physical	17643375
CTDP1_HUMAN	CTDP1	physical	17643375
RPAB3_HUMAN	POLR2H	physical	17643375
VP16_HHV11	UL48	physical	15081896
NCOR1_HUMAN	NCOR1	physical	9611234
TAF9_HUMAN	TAF9	physical	9611234
TBP_HUMAN	TBP	physical	17994014
NXF1_HUMAN	NXF1	physical	7707528
TBP_HUMAN	TBP	physical	10619841
TBP_HUMAN	TBP	physical	7671313
RPAB1_HUMAN	POLR2E	physical	9054408
TBP_HUMAN	TBP	physical	9054408
THA_HUMAN	THRA	physical	7609079
SRA1_HUMAN	SRA1	physical	20398657
TF65_HUMAN	RELA	physical	15013781
S22A2_HUMAN	SLC22A2	physical	21988832
HMGCL_HUMAN	HMGCL	physical	21988832
JAK3_HUMAN	JAK3	physical	21988832
TNIP1_HUMAN	TNIP1	physical	25416956
NC2A_HUMAN	DRAP1	physical	25416956
ILEU_HUMAN	SERPINB1	physical	26186194
CYTS_HUMAN	CST4	physical	26186194
CYTN_HUMAN	CST1	physical	26186194
CYTT_HUMAN	CST2	physical	26186194
PIGR_HUMAN	PIGR	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
MUC7_HUMAN	MUC7	physical	26186194
PRP1_HUMAN	PRB1	physical	26186194
OXSM_HUMAN	OXSM	physical	26186194
ALKB2_HUMAN	ALKBH2	physical	26344197
T2FB_HUMAN	GTF2F2	physical	26344197
NP1L1_HUMAN	NAP1L1	physical	26344197
NSUN2_HUMAN	NSUN2	physical	26344197
PRP18_HUMAN	PRPF18	physical	26344197
RFC5_HUMAN	RFC5	physical	26344197
CYTT_HUMAN	CST2	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
PRP1_HUMAN	PRB1	physical	28514442
ILEU_HUMAN	SERPINB1	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
OXSM_HUMAN	OXSM	physical	28514442
IGJ_HUMAN	IGJ	physical	28514442
MUC7_HUMAN	MUC7	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TF2B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND MASSSPECTROMETRY.	18669648 [Abstract]

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