PRP18_HUMAN - dbPTM
PRP18_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRP18_HUMAN
UniProt AC Q99633
Protein Name Pre-mRNA-splicing factor 18
Gene Name PRPF18
Organism Homo sapiens (Human).
Sequence Length 342
Subcellular Localization Nucleus speckle. Colocalizes with spliceosomal snRNPs..
Protein Description Participates in the second step of pre-mRNA splicing..
Protein Sequence MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDILKSEI
-------CCHHHHHH		6.9722814378
5 (in isoform 2)Ubiquitination-46.5121890473
5 (in isoform 1)Ubiquitination-46.5121890473
5Ubiquitination---MDILKSEILRKR
---CCHHHHHHHHHH		46.5121890473
21UbiquitinationLVEDRNLLVENKKYF
HHHHHCHHHHCHHHH		5.3224816145
36UbiquitinationKRSELAKKEEEAYFE
HHHHHHHHHHHHHHH		65.8324816145
41PhosphorylationAKKEEEAYFERCGYK
HHHHHHHHHHHCCCC		14.8422817900
60PhosphorylationEEDQKPLTSSNPVLE
CCCCCCCCCCCCEEE		38.3427251275
61PhosphorylationEDQKPLTSSNPVLEL
CCCCCCCCCCCEEEH		35.4827251275
77SulfoxidationLAEEKLPMTLSRQEV
HHHHHCCCCCCHHHH		9.4921406390
116PhosphorylationLRKIEILTPEVNKGL
HHCCEECCHHHCHHH		24.0621815630
128UbiquitinationKGLRNDLKAALDKID
HHHHHHHHHHHHHHH		34.1829967540
133UbiquitinationDLKAALDKIDQQYLN
HHHHHHHHHHHHHHH		49.3729967540
138PhosphorylationLDKIDQQYLNEIVGG
HHHHHHHHHHHHHCC		13.0827642862
247AcetylationRNLPADIKESITDII
CCCCHHHHHHHHHHH		46.0518584627
299PhosphorylationTGREKIFSKHVAHVL
CCCHHHHHHHHHHHC		25.8924719451
310PhosphorylationAHVLNDETQRKYIQG
HHHCCHHHHHHHHHH		36.22-
319AcetylationRKYIQGLKRLMTICQ
HHHHHHHHHHHHHHH		50.767976745
327AcetylationRLMTICQKHFPTDPS
HHHHHHHHHCCCCHH		42.6825953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRP18_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRP18_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRP18_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PRP18_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRP18_HUMAN

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Related Literatures of Post-Translational Modification

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