EEPD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EEPD1_HUMAN
• UniProt AC: Q7L9B9
• Protein Name: Endonuclease/exonuclease/phosphatase family domain-containing protein 1
• Gene Name: EEPD1
• Organism: Homo sapiens (Human).
• Sequence Length: 569
• Protein Sequence: MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLLAEQQPHHLATAVPLTPRVNINTATPAQLMSVRGLSEKMALSIVDFRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQPTLPNIRKWKGPRGCWKAVVAEKPSSQLQKGAGYAGFLWDAAAGMELRDAGSQESSPSNGHGKLAGPSPYLGRFKVGSHDLTLVNLHLAALTLLGSENPSKNHSDGHRLASFAQTLQETLKGEKDVIILGDFGQGPDSNDYDILRKEKFHHLIPAHTFTNISTKNPQGSKSLDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWSKKDAPRNGSGVALERSEANIKHER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGSTLGCHR ------CCCCCCCCC	29.36	-
2	Myristoylation	------MGSTLGCHR ------CCCCCCCCC	29.36	20213681
7	S-palmitoylation	-MGSTLGCHRSIPRD -CCCCCCCCCCCCCC	2.44	27480498
10	Phosphorylation	STLGCHRSIPRDPSD CCCCCCCCCCCCHHH	17.18	26657352
16	Phosphorylation	RSIPRDPSDLSHSRK CCCCCCHHHCCCCHH	56.31	24670416
19	Phosphorylation	PRDPSDLSHSRKFSA CCCHHHCCCCHHHHH	25.14	24670416
21	Phosphorylation	DPSDLSHSRKFSAAC CHHHCCCCHHHHHHC	33.51	23401153
25	Phosphorylation	LSHSRKFSAACNFSN CCCCHHHHHHCCCHH	20.28	23401153
31	Phosphorylation	FSAACNFSNILVNQE HHHHCCCHHHEECHH	14.68	30266825
70	Phosphorylation	SIVEYREYIGGFKKV HHHHHHHHHCCCCCH	8.89	-
101	Phosphorylation	VKFEICVSSKGSSAQ EEEEEEECCCCCCCC	23.17	28450419
102	Phosphorylation	KFEICVSSKGSSAQH EEEEEECCCCCCCCC	22.19	28450419
105	Phosphorylation	ICVSSKGSSAQHSPS EEECCCCCCCCCCCH	26.66	21712546
106	Phosphorylation	CVSSKGSSAQHSPSS EECCCCCCCCCCCHH	40.39	30631047
110	Phosphorylation	KGSSAQHSPSSLRRD CCCCCCCCCHHHHHH	17.88	24972180
112	Phosphorylation	SSAQHSPSSLRRDLL CCCCCCCHHHHHHHH	45.05	21712546
113	Phosphorylation	SAQHSPSSLRRDLLA CCCCCCHHHHHHHHH	29.31	22115753
129	Phosphorylation	QQPHHLATAVPLTPR HCCCCEECCCCCCCC	34.25	30266825
134	Phosphorylation	LATAVPLTPRVNINT EECCCCCCCCCCCCC	11.72	23401153
143	Phosphorylation	RVNINTATPAQLMSV CCCCCCCCHHHHHHH	19.67	28555341
149	Phosphorylation	ATPAQLMSVRGLSEK CCHHHHHHHCCCCHH	19.77	24719451
154	Phosphorylation	LMSVRGLSEKMALSI HHHHCCCCHHHCHHH	37.69	24719451
156	Ubiquitination	SVRGLSEKMALSIVD HHCCCCHHHCHHHHH	26.54	32015554
160	Phosphorylation	LSEKMALSIVDFRRE CCHHHCHHHHHHHHH	15.84	24670416
173	Phosphorylation	REHGPFRSVEDLVRM HHHCCCCCHHHHHHC	30.18	29255136
200	Phosphorylation	HQVFAERSRPPSTHT HHHHHCCCCCCCCCC	40.41	20363803
204	Phosphorylation	AERSRPPSTHTNGGL HCCCCCCCCCCCCCE	35.19	26657352
205	Phosphorylation	ERSRPPSTHTNGGLT CCCCCCCCCCCCCEE	38.19	20363803
207	Phosphorylation	SRPPSTHTNGGLTFT CCCCCCCCCCCEEEE	35.33	26657352
212	Phosphorylation	THTNGGLTFTAKPHP CCCCCCEEEECCCCC	23.39	29052541
214	Phosphorylation	TNGGLTFTAKPHPSP CCCCEEEECCCCCCC	28.65	29052541
220	Phosphorylation	FTAKPHPSPTSLSLQ EECCCCCCCCCEEEE	37.46	27732954
222	Phosphorylation	AKPHPSPTSLSLQSE CCCCCCCCCEEEEEC	46.79	27732954
223	Phosphorylation	KPHPSPTSLSLQSED CCCCCCCCEEEEECC	21.24	27732954
225	Phosphorylation	HPSPTSLSLQSEDLD CCCCCCEEEEECCCC	24.91	27732954
228	Phosphorylation	PTSLSLQSEDLDLPP CCCEEEEECCCCCCC	38.07	27732954
239	Phosphorylation	DLPPGGPTQIISTRP CCCCCCCCEEEEECC	35.36	26074081
243	Phosphorylation	GGPTQIISTRPSVEA CCCCEEEEECCCEEC	21.72	26074081
244	Phosphorylation	GPTQIISTRPSVEAF CCCEEEEECCCEECC	35.87	26074081
247	Phosphorylation	QIISTRPSVEAFGGT EEEEECCCEECCCCC	29.33	26074081
254	Phosphorylation	SVEAFGGTRDGRPVL CEECCCCCCCCCEEE	26.43	26471730
265	Phosphorylation	RPVLRLATWNLQGCS CEEEEEEEEECCCCC	21.34	-
313	Phosphorylation	EALEKFCTELNQPTL HHHHHHHHHHCCCCC	46.79	26270265
319	Phosphorylation	CTELNQPTLPNIRKW HHHHCCCCCCCCCCC	45.12	26270265
385	Phosphorylation	HGKLAGPSPYLGRFK CCCCCCCCCCCCCEE	25.84	22985185
387	Phosphorylation	KLAGPSPYLGRFKVG CCCCCCCCCCCEECC	26.57	23312004
421	Phosphorylation	ENPSKNHSDGHRLAS CCCCCCCCCHHHHHH	55.47	20068231
428	Phosphorylation	SDGHRLASFAQTLQE CCHHHHHHHHHHHHH	26.21	11214970
432	Phosphorylation	RLASFAQTLQETLKG HHHHHHHHHHHHHCC	27.29	20068231
436	Phosphorylation	FAQTLQETLKGEKDV HHHHHHHHHCCCCCE	22.32	20068231
487	Ubiquitination	TKNPQGSKSLDNIWI CCCCCCCCCCCEEEE	62.96	32015554
496	Ubiquitination	LDNIWISKSLKKVFT CCEEEECHHHHHHHC	51.15	21890473
499	Ubiquitination	IWISKSLKKVFTGHW EEECHHHHHHHCCCE	54.72	22817900
500	Ubiquitination	WISKSLKKVFTGHWA EECHHHHHHHCCCEE	48.12	22817900
554	Phosphorylation	KDAPRNGSGVALERS CCCCCCCCCCCCCCH	33.37	22617229
560	Methylation	GSGVALERSEANIKH CCCCCCCCHHHCCCC	40.42	-
561	Phosphorylation	SGVALERSEANIKHE CCCCCCCHHHCCCCC	31.52	28634120
569	Methylation	EANIKHER------- HHCCCCCC-------	52.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EEPD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EEPD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EEPD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Strategy for comprehensive identification of human N-myristoylatedproteins using an insect cell-free protein synthesis system.";
Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,Tsunasawa S., Utsumi T.;
Proteomics 10:1780-1793(2010).
Cited for: MYRISTOYLATION AT GLY-2.
PubMed: 20213681