dbPTM

ALBU_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ALBU_HUMAN
UniProt AC	P02768
Protein Name	Serum albumin
Gene Name	ALB
Organism	Homo sapiens (Human).
Sequence Length	609
Subcellular Localization	Secreted.
Protein Description	Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc..
Protein Sequence	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKWVTFISLLFL ---CCHHHHHHHHHH	17.71	20071362
14	Phosphorylation	ISLLFLFSSAYSRGV HHHHHHHHHHHHCCC	19.06	46161837
17	Phosphorylation	LFLFSSAYSRGVFRR HHHHHHHHHCCCCCH	10.80	46161893
18	Phosphorylation	FLFSSAYSRGVFRRD HHHHHHHHCCCCCHH	23.44	46161843
28	Acetylation	VFRRDAHKSEVAHRF CCCHHHHHHHHHHHH	50.46	18577514
28	Glycation	VFRRDAHKSEVAHRF CCCHHHHHHHHHHHH	50.46	-
29	Phosphorylation	FRRDAHKSEVAHRFK CCHHHHHHHHHHHHH	27.69	28857561
36	Acetylation	SEVAHRFKDLGEENF HHHHHHHHHHCHHHH	52.58	19836360
36	Glycation	SEVAHRFKDLGEENF HHHHHHHHHHCHHHH	52.58	-
36	N-linked_Glycosylation	SEVAHRFKDLGEENF HHHHHHHHHHCHHHH	52.58	3759977
44	Acetylation	DLGEENFKALVLIAF HHCHHHHHHHHHHHH	53.01	18577514
44	Glycation	DLGEENFKALVLIAF HHCHHHHHHHHHHHH	53.01	-
54	Nitration	VLIAFAQYLQQCPFE HHHHHHHHHHHCCCH	11.75	-
54	Phosphorylation	VLIAFAQYLQQCPFE HHHHHHHHHHHCCCH	11.75	22673903
58	Glutathionylation	FAQYLQQCPFEDHVK HHHHHHHCCCHHHHH	2.41	24333276
58	S-nitrosylation	FAQYLQQCPFEDHVK HHHHHHHCCCHHHHH	2.41	25040305
65	Acetylation	CPFEDHVKLVNEVTE CCCHHHHHHHHHHHH	43.21	18577514
65	Glycation	CPFEDHVKLVNEVTE CCCHHHHHHHHHHHH	43.21	-
71	O-linked_Glycosylation	VKLVNEVTEFAKTCV HHHHHHHHHHHHHHC	21.14	OGP
71	Phosphorylation	VKLVNEVTEFAKTCV HHHHHHHHHHHHHHC	21.14	28857561
75	Acetylation	NEVTEFAKTCVADES HHHHHHHHHHCCCHH	48.02	18577514
75	Glycation	NEVTEFAKTCVADES HHHHHHHHHHCCCHH	48.02	-
75	Methylation	NEVTEFAKTCVADES HHHHHHHHHHCCCHH	48.02	-
75	N-linked_Glycosylation	NEVTEFAKTCVADES HHHHHHHHHHCCCHH	48.02	15047055
76	Phosphorylation	EVTEFAKTCVADESA HHHHHHHHHCCCHHH	14.58	28258704
77	S-nitrosylation	VTEFAKTCVADESAE HHHHHHHHCCCHHHH	2.04	25040305
82	Phosphorylation	KTCVADESAENCDKS HHHCCCHHHHCCCHH	41.24	23401153
86	S-nitrosylation	ADESAENCDKSLHTL CCHHHHCCCHHHHHH	5.40	25040305
88	Acetylation	ESAENCDKSLHTLFG HHHHCCCHHHHHHHH	58.05	18577514
88	Glycation	ESAENCDKSLHTLFG HHHHCCCHHHHHHHH	58.05	-
89	O-linked_Glycosylation	SAENCDKSLHTLFGD HHHCCCHHHHHHHHC	16.48	26853435
89	Phosphorylation	SAENCDKSLHTLFGD HHHCCCHHHHHHHHC	16.48	30087585
92	Phosphorylation	NCDKSLHTLFGDKLC CCCHHHHHHHHCHHH	29.13	27130503
97	Acetylation	LHTLFGDKLCTVATL HHHHHHCHHHHHHHH	45.93	19836360
97	Glycation	LHTLFGDKLCTVATL HHHHHHCHHHHHHHH	45.93	-
97	Ubiquitination	LHTLFGDKLCTVATL HHHHHHCHHHHHHHH	45.93	32015554
99	S-nitrosylation	TLFGDKLCTVATLRE HHHHCHHHHHHHHHH	3.37	25040305
100	Phosphorylation	LFGDKLCTVATLRET HHHCHHHHHHHHHHH	24.50	22985185
103	Phosphorylation	DKLCTVATLRETYGE CHHHHHHHHHHHHHH	23.24	22985185
107	Phosphorylation	TVATLRETYGEMADC HHHHHHHHHHHHHHH	30.32	19060867
108	Nitration	VATLRETYGEMADCC HHHHHHHHHHHHHHH	13.31	-
108	Phosphorylation	VATLRETYGEMADCC HHHHHHHHHHHHHHH	13.31	21253578
111	Sulfoxidation	LRETYGEMADCCAKQ HHHHHHHHHHHHHHC	3.11	21192028
114	S-nitrosylation	TYGEMADCCAKQEPE HHHHHHHHHHHCCCC	1.44	25040305
115	S-nitrosylation	YGEMADCCAKQEPER HHHHHHHHHHCCCCC	5.65	25040305
117	Acetylation	EMADCCAKQEPERNE HHHHHHHHCCCCCCC	41.08	19836360
117	Glycation	EMADCCAKQEPERNE HHHHHHHHCCCCCCC	41.08	-
125	S-nitrosylation	QEPERNECFLQHKDD CCCCCCCCCHHCCCC	4.75	25040305
130	Acetylation	NECFLQHKDDNPNLP CCCCHHCCCCCCCCC	54.54	19836360
147	Sulfoxidation	VRPEVDVMCTAFHDN CCCCCCEEEEECCCC	1.13	21192028
148	S-nitrosylation	RPEVDVMCTAFHDNE CCCCCEEEEECCCCH	2.20	25040305
149	O-linked_Glycosylation	PEVDVMCTAFHDNEE CCCCEEEEECCCCHH	17.79	OGP
149	Phosphorylation	PEVDVMCTAFHDNEE CCCCEEEEECCCCHH	17.79	28258704
160	Acetylation	DNEETFLKKYLYEIA CCHHHHHHHHHHHHH	34.87	19836360
160	Glycation	DNEETFLKKYLYEIA CCHHHHHHHHHHHHH	34.87	-
161	Acetylation	NEETFLKKYLYEIAR CHHHHHHHHHHHHHH	42.51	19836360
161	Glycation	NEETFLKKYLYEIAR CHHHHHHHHHHHHHH	42.51	-
161	N-linked_Glycosylation	NEETFLKKYLYEIAR CHHHHHHHHHHHHHH	42.51	15047055
162	Nitration	EETFLKKYLYEIARR HHHHHHHHHHHHHHH	16.96	-
162	Phosphorylation	EETFLKKYLYEIARR HHHHHHHHHHHHHHH	16.96	17016520
164	Phosphorylation	TFLKKYLYEIARRHP HHHHHHHHHHHHHCC	11.38	25884760
168	Methylation	KYLYEIARRHPYFYA HHHHHHHHHCCCCCC	43.00	-
172	Nitration	EIARRHPYFYAPELL HHHHHCCCCCCHHHH	11.78	-
172	Phosphorylation	EIARRHPYFYAPELL HHHHHCCCCCCHHHH	11.78	28857561
174	Nitration	ARRHPYFYAPELLFF HHHCCCCCCHHHHHH	18.53	-
174	Phosphorylation	ARRHPYFYAPELLFF HHHCCCCCCHHHHHH	18.53	21253578
183	Acetylation	PELLFFAKRYKAAFT HHHHHHHHHHHHHHH	51.62	19836360
183	Glycation	PELLFFAKRYKAAFT HHHHHHHHHHHHHHH	51.62	-
185	Nitration	LLFFAKRYKAAFTEC HHHHHHHHHHHHHHH	12.31	-
186	Acetylation	LFFAKRYKAAFTECC HHHHHHHHHHHHHHH	36.95	19836360
186	Glycation	LFFAKRYKAAFTECC HHHHHHHHHHHHHHH	36.95	-
186	N-linked_Glycosylation	LFFAKRYKAAFTECC HHHHHHHHHHHHHHH	36.95	15047055
190	Phosphorylation	KRYKAAFTECCQAAD HHHHHHHHHHHHHHH	24.32	108826581
192	S-nitrosylation	YKAAFTECCQAADKA HHHHHHHHHHHHHHH	1.57	25040305
193	S-nitrosylation	KAAFTECCQAADKAA HHHHHHHHHHHHHHH	2.22	25040305
198	Acetylation	ECCQAADKAACLLPK HHHHHHHHHHHHHHH	32.91	19836360
198	Glycation	ECCQAADKAACLLPK HHHHHHHHHHHHHHH	32.91	-
201	S-nitrosylation	QAADKAACLLPKLDE HHHHHHHHHHHHHHH	4.85	25040305
205	Acetylation	KAACLLPKLDELRDE HHHHHHHHHHHHHHC	69.41	18577514
205	Glycation	KAACLLPKLDELRDE HHHHHHHHHHHHHHC	69.41	-
214	Acetylation	DELRDEGKASSAKQR HHHHHCCCCCHHHHH	42.94	18577514
214	Glycation	DELRDEGKASSAKQR HHHHHCCCCCHHHHH	42.94	-
216	Phosphorylation	LRDEGKASSAKQRLK HHHCCCCCHHHHHHH	34.02	27130503
217	Phosphorylation	RDEGKASSAKQRLKC HHCCCCCHHHHHHHH	44.33	46161849
219	Acetylation	EGKASSAKQRLKCAS CCCCCHHHHHHHHHH	37.59	18577514
219	Glycation	EGKASSAKQRLKCAS CCCCCHHHHHHHHHH	37.59	-
223	Acetylation	SSAKQRLKCASLQKF CHHHHHHHHHHHHHH	29.91	11170515
223	Glycation	SSAKQRLKCASLQKF CHHHHHHHHHHHHHH	29.91	-
223	N-linked_Glycosylation	SSAKQRLKCASLQKF CHHHHHHHHHHHHHH	29.91	6853480
224	Glutathionylation	SAKQRLKCASLQKFG HHHHHHHHHHHHHHH	3.53	24333276
229	Acetylation	LKCASLQKFGERAFK HHHHHHHHHHHHHHH	61.71	26051181
229	Glycation	LKCASLQKFGERAFK HHHHHHHHHHHHHHH	61.71	-
229	Succinylation	LKCASLQKFGERAFK HHHHHHHHHHHHHHH	61.71	-
229	Succinylation	LKCASLQKFGERAFK HHHHHHHHHHHHHHH	61.71	19836360
229	Ubiquitination	LKCASLQKFGERAFK HHHHHHHHHHHHHHH	61.71	19836360
229 (in isoform 1)	Ubiquitination	-	61.71	21890473
236	Acetylation	KFGERAFKAWAVARL HHHHHHHHHHHHHHH	41.87	19836360
244	Phosphorylation	AWAVARLSQRFPKAE HHHHHHHHHHCCHHH	17.47	24719451
249	Acetylation	RLSQRFPKAEFAEVS HHHHHCCHHHHHHHH	58.81	19836360
249	Glycation	RLSQRFPKAEFAEVS HHHHHCCHHHHHHHH	58.81	-
249	N-linked_Glycosylation	RLSQRFPKAEFAEVS HHHHHCCHHHHHHHH	58.81	15047055
256	Phosphorylation	KAEFAEVSKLVTDLT HHHHHHHHHHHHHHH	16.27	101545747
257	Acetylation	AEFAEVSKLVTDLTK HHHHHHHHHHHHHHH	52.75	27178108
257	Glycation	AEFAEVSKLVTDLTK HHHHHHHHHHHHHHH	52.75	-
257	N-linked_Glycosylation	AEFAEVSKLVTDLTK HHHHHHHHHHHHHHH	52.75	3759977
260	Phosphorylation	AEVSKLVTDLTKVHT HHHHHHHHHHHHHCH	35.41	28857561
263	Phosphorylation	SKLVTDLTKVHTECC HHHHHHHHHHCHHHC	33.55	69301829
264	Acetylation	KLVTDLTKVHTECCH HHHHHHHHHCHHHCC	39.04	18577514
267	Phosphorylation	TDLTKVHTECCHGDL HHHHHHCHHHCCCCH	33.43	28258704
269	S-nitrosylation	LTKVHTECCHGDLLE HHHHCHHHCCCCHHH	1.87	25040305
270	S-nitrosylation	TKVHTECCHGDLLEC HHHCHHHCCCCHHHC	3.06	25040305
286	Acetylation	DDRADLAKYICENQD CCHHHHHHHHHHCCH	42.31	26051181
286	Glycation	DDRADLAKYICENQD CCHHHHHHHHHHCCH	42.31	-
286	Ubiquitination	DDRADLAKYICENQD CCHHHHHHHHHHCCH	42.31	32015554
287	Nitration	DRADLAKYICENQDS CHHHHHHHHHHCCHH	12.75	-
287	Phosphorylation	DRADLAKYICENQDS CHHHHHHHHHHCCHH	12.75	23911959
289	S-nitrosylation	ADLAKYICENQDSIS HHHHHHHHHCCHHHH	3.49	25040305
294	Phosphorylation	YICENQDSISSKLKE HHHHCCHHHHHHHHH	18.01	27130503
296	Phosphorylation	CENQDSISSKLKECC HHCCHHHHHHHHHHH	25.93	113304533
297	Phosphorylation	ENQDSISSKLKECCE HCCHHHHHHHHHHHC	40.10	27130503
298	Acetylation	NQDSISSKLKECCEK CCHHHHHHHHHHHCC	57.71	26051181
298	Glycation	NQDSISSKLKECCEK CCHHHHHHHHHHHCC	57.71	-
298	Neddylation	NQDSISSKLKECCEK CCHHHHHHHHHHHCC	57.71	32015554
298	Ubiquitination	NQDSISSKLKECCEK CCHHHHHHHHHHHCC	57.71	32015554
300	Acetylation	DSISSKLKECCEKPL HHHHHHHHHHHCCHH	53.06	18577514
300	Glycation	DSISSKLKECCEKPL HHHHHHHHHHHCCHH	53.06	-
300	N-linked_Glycosylation	DSISSKLKECCEKPL HHHHHHHHHHHCCHH	53.06	15047055
303	S-nitrosylation	SSKLKECCEKPLLEK HHHHHHHHCCHHHHH	8.70	25040305
305	Acetylation	KLKECCEKPLLEKSH HHHHHHCCHHHHHCC	27.35	19836360
305	Glycation	KLKECCEKPLLEKSH HHHHHHCCHHHHHCC	27.35	-
305	N-linked_Glycosylation	KLKECCEKPLLEKSH HHHHHHCCHHHHHCC	27.35	3759977
310	Acetylation	CEKPLLEKSHCIAEV HCCHHHHHCCCEEEE	45.53	18577514
310	Glycation	CEKPLLEKSHCIAEV HCCHHHHHCCCEEEE	45.53	-
311	Phosphorylation	EKPLLEKSHCIAEVE CCHHHHHCCCEEEEC	17.76	28258704
313	S-nitrosylation	PLLEKSHCIAEVEND HHHHHCCCEEEECCC	3.99	25040305
328	Phosphorylation	EMPADLPSLAADFVE CCCCCCHHHHHHHHH	37.63	27130503
336	Phosphorylation	LAADFVESKDVCKNY HHHHHHHCHHHHHHH	28.93	27130503
337	Acetylation	AADFVESKDVCKNYA HHHHHHCHHHHHHHH	40.45	18577514
337	Glycation	AADFVESKDVCKNYA HHHHHHCHHHHHHHH	40.45	-
337	N-linked_Glycosylation	AADFVESKDVCKNYA HHHHHHCHHHHHHHH	40.45	15047055
341	Acetylation	VESKDVCKNYAEAKD HHCHHHHHHHHHHHH	53.49	18577514
341	Glycation	VESKDVCKNYAEAKD HHCHHHHHHHHHHHH	53.49	-
341	N-linked_Glycosylation	VESKDVCKNYAEAKD HHCHHHHHHHHHHHH	53.49	3759977
342	N-linked_Glycosylation	ESKDVCKNYAEAKDV HCHHHHHHHHHHHHH	35.80	UniProtKB CARBOHYD
343	Phosphorylation	SKDVCKNYAEAKDVF CHHHHHHHHHHHHHH	7.42	24415223
347	Acetylation	CKNYAEAKDVFLGMF HHHHHHHHHHHHHHH	46.02	19836360
347	Glycation	CKNYAEAKDVFLGMF HHHHHHHHHHHHHHH	46.02	-
347	N-linked_Glycosylation	CKNYAEAKDVFLGMF HHHHHHHHHHHHHHH	46.02	15047055
358	Nitration	LGMFLYEYARRHPDY HHHHHHHHHHHCCCH	7.58	-
365	Nitration	YARRHPDYSVVLLLR HHHHCCCHHHHHHHH	14.07	-
365	Phosphorylation	YARRHPDYSVVLLLR HHHHCCCHHHHHHHH	14.07	21253578
366	Phosphorylation	ARRHPDYSVVLLLRL HHHCCCHHHHHHHHH	17.09	20307869
375	Acetylation	VLLLRLAKTYETTLE HHHHHHHHHHHHHHH	57.12	19836360
375	Glycation	VLLLRLAKTYETTLE HHHHHHHHHHHHHHH	57.12	-
375	N-linked_Glycosylation	VLLLRLAKTYETTLE HHHHHHHHHHHHHHH	57.12	3759977
376	Phosphorylation	LLLRLAKTYETTLEK HHHHHHHHHHHHHHH	22.45	20308961
377	Phosphorylation	LLRLAKTYETTLEKC HHHHHHHHHHHHHHH	15.57	21253578
379	Phosphorylation	RLAKTYETTLEKCCA HHHHHHHHHHHHHHH	26.68	20308971
380	Phosphorylation	LAKTYETTLEKCCAA HHHHHHHHHHHHHHC	22.45	69301831
383	Acetylation	TYETTLEKCCAAADP HHHHHHHHHHHCCCH	37.41	18577514
383	Glycation	TYETTLEKCCAAADP HHHHHHHHHHHCCCH	37.41	-
385	S-nitrosylation	ETTLEKCCAAADPHE HHHHHHHHHCCCHHH	4.23	25040305
394	Nitration	AADPHECYAKVFDEF CCCHHHHHHHHHHHH	13.38	-
394	Phosphorylation	AADPHECYAKVFDEF CCCHHHHHHHHHHHH	13.38	21253578
396	Acetylation	DPHECYAKVFDEFKP CHHHHHHHHHHHHHH	19.57	18577514
396	Glycation	DPHECYAKVFDEFKP CHHHHHHHHHHHHHH	19.57	-
402	Acetylation	AKVFDEFKPLVEEPQ HHHHHHHHHHHHCCH	35.08	19836360
402	Glycation	AKVFDEFKPLVEEPQ HHHHHHHHHHHHCCH	35.08	-
402	N-linked_Glycosylation	AKVFDEFKPLVEEPQ HHHHHHHHHHHHCCH	35.08	15047055
413	Acetylation	EEPQNLIKQNCELFE HCCHHHHHHHHHHHH	38.33	18577514
413	Glycation	EEPQNLIKQNCELFE HCCHHHHHHHHHHHH	38.33	-
416	S-nitrosylation	QNLIKQNCELFEQLG HHHHHHHHHHHHHHC	4.44	25040305
416	S-palmitoylation	QNLIKQNCELFEQLG HHHHHHHHHHHHHHC	4.44	26865113
425	Nitration	LFEQLGEYKFQNALL HHHHHCCHHHCCEEE	18.46	-
425	Phosphorylation	LFEQLGEYKFQNALL HHHHHCCHHHCCEEE	18.46	132033
426	Acetylation	FEQLGEYKFQNALLV HHHHCCHHHCCEEEE	35.85	19836360
426	Glycation	FEQLGEYKFQNALLV HHHHCCHHHCCEEEE	35.85	-
435	Nitration	QNALLVRYTKKVPQV CCEEEEEECCCCCCC	18.55	-
435	Phosphorylation	QNALLVRYTKKVPQV CCEEEEEECCCCCCC	18.55	28857561
436	Phosphorylation	NALLVRYTKKVPQVS CEEEEEECCCCCCCC	17.52	28857561
437	Acetylation	ALLVRYTKKVPQVST EEEEEECCCCCCCCC	42.72	19836360
437	Glycation	ALLVRYTKKVPQVST EEEEEECCCCCCCCC	42.72	-
437	N-linked_Glycosylation	ALLVRYTKKVPQVST EEEEEECCCCCCCCC	42.72	15047055
438	Acetylation	LLVRYTKKVPQVSTP EEEEECCCCCCCCCC	51.88	21466224
438	Glycation	LLVRYTKKVPQVSTP EEEEECCCCCCCCCC	51.88	-
438	Ubiquitination	LLVRYTKKVPQVSTP EEEEECCCCCCCCCC	51.88	33845483
443	O-linked_Glycosylation	TKKVPQVSTPTLVEV CCCCCCCCCCCHHHH	24.34	OGP
443	Phosphorylation	TKKVPQVSTPTLVEV CCCCCCCCCCCHHHH	24.34	23911959
444	O-linked_Glycosylation	KKVPQVSTPTLVEVS CCCCCCCCCCHHHHH	22.80	28318525
444	Phosphorylation	KKVPQVSTPTLVEVS CCCCCCCCCCHHHHH	22.80	23911959
446	O-linked_Glycosylation	VPQVSTPTLVEVSRN CCCCCCCCHHHHHHH	43.45	OGP
446	Phosphorylation	VPQVSTPTLVEVSRN CCCCCCCCHHHHHHH	43.45	23403867
451	O-linked_Glycosylation	TPTLVEVSRNLGKVG CCCHHHHHHHHCCCC	11.27	OGP
451	Phosphorylation	TPTLVEVSRNLGKVG CCCHHHHHHHHCCCC	11.27	46161865
456	Acetylation	EVSRNLGKVGSKCCK HHHHHHCCCCHHHCC	46.73	18577514
456	Glycation	EVSRNLGKVGSKCCK HHHHHHCCCCHHHCC	46.73	-
460	Acetylation	NLGKVGSKCCKHPEA HHCCCCHHHCCCHHH	37.41	18577514
460	Glycation	NLGKVGSKCCKHPEA HHCCCCHHHCCCHHH	37.41	-
460	Succinylation	NLGKVGSKCCKHPEA HHCCCCHHHCCCHHH	37.41	-
460	Succinylation	NLGKVGSKCCKHPEA HHCCCCHHHCCCHHH	37.41	-
463	Acetylation	KVGSKCCKHPEAKRM CCCHHHCCCHHHHCC	72.21	18577514
463	Glycation	KVGSKCCKHPEAKRM CCCHHHCCCHHHHCC	72.21	-
463	N-linked_Glycosylation	KVGSKCCKHPEAKRM CCCHHHCCCHHHHCC	72.21	3759977
468	Acetylation	CCKHPEAKRMPCAED HCCCHHHHCCCCHHH	47.79	18577514
468	Glycation	CCKHPEAKRMPCAED HCCCHHHHCCCCHHH	47.79	-
468	N-linked_Glycosylation	CCKHPEAKRMPCAED HCCCHHHHCCCCHHH	47.79	15047055
472	S-nitrosylation	PEAKRMPCAEDYLSV HHHHCCCCHHHHHHH	4.78	25040305
476	Nitration	RMPCAEDYLSVVLNQ CCCCHHHHHHHHHHH	7.74	-
476	Phosphorylation	RMPCAEDYLSVVLNQ CCCCHHHHHHHHHHH	7.74	26657352
478	Phosphorylation	PCAEDYLSVVLNQLC CCHHHHHHHHHHHHH	12.16	30087585
485	S-nitrosylation	SVVLNQLCVLHEKTP HHHHHHHHHHCCCCC	1.89	25040305
490	Acetylation	QLCVLHEKTPVSDRV HHHHHCCCCCCCHHH	47.59	18577514
490	Glycation	QLCVLHEKTPVSDRV HHHHHCCCCCCCHHH	47.59	-
490	Methylation	QLCVLHEKTPVSDRV HHHHHCCCCCCCHHH	47.59	-
498	O-linked_Glycosylation	TPVSDRVTKCCTESL CCCCHHHHHHHHHHH	21.18	OGP
498	Phosphorylation	TPVSDRVTKCCTESL CCCCHHHHHHHHHHH	21.18	113304563
499	Acetylation	PVSDRVTKCCTESLV CCCHHHHHHHHHHHH	25.18	18577514
499	Glycation	PVSDRVTKCCTESLV CCCHHHHHHHHHHHH	25.18	-
499	Ubiquitination	PVSDRVTKCCTESLV CCCHHHHHHHHHHHH	25.18	33845483
500	Glutathionylation	VSDRVTKCCTESLVN CCHHHHHHHHHHHHH	2.25	24333276
500	S-nitrosylation	VSDRVTKCCTESLVN CCHHHHHHHHHHHHH	2.25	25040305
502	Phosphorylation	DRVTKCCTESLVNRR HHHHHHHHHHHHHCC	37.77	23911959
504	Phosphorylation	VTKCCTESLVNRRPC HHHHHHHHHHHCCCC	21.33	108826595
511	S-nitrosylation	SLVNRRPCFSALEVD HHHHCCCCCCEEEEC	3.90	25040305
513	Phosphorylation	VNRRPCFSALEVDET HHCCCCCCEEEECCC	38.37	27251275
518	N-linked_Glycosylation	CFSALEVDETYVPKE CCCEEEECCCCCCCC	32.90	-
520	O-linked_Glycosylation	SALEVDETYVPKEFN CEEEECCCCCCCCCC	25.92	OGP
520	Phosphorylation	SALEVDETYVPKEFN CEEEECCCCCCCCCC	25.92	46161875
521	Nitration	ALEVDETYVPKEFNA EEEECCCCCCCCCCC	16.83	-
521	Phosphorylation	ALEVDETYVPKEFNA EEEECCCCCCCCCCC	16.83	18083107
524	Acetylation	VDETYVPKEFNAETF ECCCCCCCCCCCCEE	65.96	18577514
524	Glycation	VDETYVPKEFNAETF ECCCCCCCCCCCCEE	65.96	-
530	O-linked_Glycosylation	PKEFNAETFTFHADI CCCCCCCEEEEEEEE	26.09	OGP
532	O-linked_Glycosylation	EFNAETFTFHADICT CCCCCEEEEEEEECC	23.18	OGP
538	S-nitrosylation	FTFHADICTLSEKER EEEEEEECCCCHHHH	3.01	25040305
539	Phosphorylation	TFHADICTLSEKERQ EEEEEECCCCHHHHH	33.38	27251275
541	Phosphorylation	HADICTLSEKERQIK EEEECCCCHHHHHHH	28.59	27251275
543	Acetylation	DICTLSEKERQIKKQ EECCCCHHHHHHHHH	55.62	19836360
543	Glycation	DICTLSEKERQIKKQ EECCCCHHHHHHHHH	55.62	-
543	Succinylation	DICTLSEKERQIKKQ EECCCCHHHHHHHHH	55.62	-
543	Succinylation	DICTLSEKERQIKKQ EECCCCHHHHHHHHH	55.62	-
548	Acetylation	SEKERQIKKQTALVE CHHHHHHHHHHHHHH	30.41	18577514
548	Glycation	SEKERQIKKQTALVE CHHHHHHHHHHHHHH	30.41	-
549	Acetylation	EKERQIKKQTALVEL HHHHHHHHHHHHHHH	55.28	19836360
549	Glycation	EKERQIKKQTALVEL HHHHHHHHHHHHHHH	55.28	-
549	N-linked_Glycosylation	EKERQIKKQTALVEL HHHHHHHHHHHHHHH	55.28	6853480
551	O-linked_Glycosylation	ERQIKKQTALVELVK HHHHHHHHHHHHHHH	30.73	OGP
551	Phosphorylation	ERQIKKQTALVELVK HHHHHHHHHHHHHHH	30.73	28857561
558	Acetylation	TALVELVKHKPKATK HHHHHHHHCCCCCCH	59.54	18577514
558	Glycation	TALVELVKHKPKATK HHHHHHHHCCCCCCH	59.54	-
558	Methylation	TALVELVKHKPKATK HHHHHHHHCCCCCCH	59.54	24129315
558	N-linked_Glycosylation	TALVELVKHKPKATK HHHHHHHHCCCCCCH	59.54	3759977
560	Acetylation	LVELVKHKPKATKEQ HHHHHHCCCCCCHHH	42.36	18577514
560	Glycation	LVELVKHKPKATKEQ HHHHHHCCCCCCHHH	42.36	-
560	N-linked_Glycosylation	LVELVKHKPKATKEQ HHHHHHCCCCCCHHH	42.36	15047055
562	Acetylation	ELVKHKPKATKEQLK HHHHCCCCCCHHHHH	73.77	18577514
564	Phosphorylation	VKHKPKATKEQLKAV HHCCCCCCHHHHHHH	41.04	50564571
565	Acetylation	KHKPKATKEQLKAVM HCCCCCCHHHHHHHH	48.61	19836360
565	Glycation	KHKPKATKEQLKAVM HCCCCCCHHHHHHHH	48.61	-
569	Acetylation	KATKEQLKAVMDDFA CCCHHHHHHHHHHHH	38.33	19836360
569	Glycation	KATKEQLKAVMDDFA CCCHHHHHHHHHHHH	38.33	-
569	N-linked_Glycosylation	KATKEQLKAVMDDFA CCCHHHHHHHHHHHH	38.33	15047055
572	Sulfoxidation	KEQLKAVMDDFAAFV HHHHHHHHHHHHHHH	4.97	21192028
581	Acetylation	DFAAFVEKCCKADDK HHHHHHHHHCCCCCC	39.36	19836360
581	Glycation	DFAAFVEKCCKADDK HHHHHHHHHCCCCCC	39.36	-
584	Acetylation	AFVEKCCKADDKETC HHHHHHCCCCCCCCC	65.41	18577514
584	Glycation	AFVEKCCKADDKETC HHHHHHCCCCCCCCC	65.41	-
588	Acetylation	KCCKADDKETCFAEE HHCCCCCCCCCCHHH	56.31	18577514
588	Glycation	KCCKADDKETCFAEE HHCCCCCCCCCCHHH	56.31	-
588	Succinylation	KCCKADDKETCFAEE HHCCCCCCCCCCHHH	56.31	-
588	Succinylation	KCCKADDKETCFAEE HHCCCCCCCCCCHHH	56.31	-
590	Phosphorylation	CKADDKETCFAEEGK CCCCCCCCCCHHHHH	20.75	28258704
591	S-nitrosylation	KADDKETCFAEEGKK CCCCCCCCCHHHHHH	2.97	25040305
597	Acetylation	TCFAEEGKKLVAASQ CCCHHHHHHHHHHHH	46.33	18577514
597	Glycation	TCFAEEGKKLVAASQ CCCHHHHHHHHHHHH	46.33	-
597	N-linked_Glycosylation	TCFAEEGKKLVAASQ CCCHHHHHHHHHHHH	46.33	15047055
598	Acetylation	CFAEEGKKLVAASQA CCHHHHHHHHHHHHH	60.08	18577514
598	Glycation	CFAEEGKKLVAASQA CCHHHHHHHHHHHHH	60.08	-
603	Phosphorylation	GKKLVAASQAALGL- HHHHHHHHHHHHCC-	15.60	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
29	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
82	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
89	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
107	T	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
223	K	Acetylation	955075
Acetylated on Lys-223 by acetylsalicylic acid.
620	T	Glycosylation	-
Kenitra variant is partially O-glycosylated at Thr-620.
620	T	Nitration	-
Kenitra variant is partially O-glycosylated at Thr-620.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ALBU_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LC7L2_HUMAN	LUC7L2	physical	16169070
FCGRN_HUMAN	FCGRT	physical	12566415
A4_HUMAN	APP	physical	21832049
ADA1B_HUMAN	ADRA1B	physical	15174051
APOA1_HUMAN	APOA1	physical	15174051
APOC1_HUMAN	APOC1	physical	15174051
SETX_HUMAN	SETX	physical	15174051
KCMA1_HUMAN	KCNMA1	physical	15174051
PDE4B_HUMAN	PDE4B	physical	15174051
CATL1_HUMAN	CTSL	physical	15174051
CDC45_HUMAN	CDC45	physical	15174051
CXG2_HUMAN	GJC2	physical	15174051
CDCP1_HUMAN	CDCP1	physical	15174051
DDB1_HUMAN	DDB1	physical	15174051
FIBA_HUMAN	FGA	physical	15174051
FINC_HUMAN	FN1	physical	15174051
GABR1_HUMAN	GABBR1	physical	15174051
HPT_HUMAN	HP	physical	15174051
K1C10_HUMAN	KRT10	physical	15174051
K1C14_HUMAN	KRT14	physical	15174051
K1C9_HUMAN	KRT9	physical	15174051
K2C1_HUMAN	KRT1	physical	15174051
OR8D2_HUMAN	OR8D2	physical	15174051
KLK3_HUMAN	KLK3	physical	15174051
ATM_HUMAN	ATM	physical	15174051
OR2T6_HUMAN	OR2T6	physical	15174051
TLN2_HUMAN	TLN2	physical	15174051
TTHY_HUMAN	TTR	physical	15174051
CAC1I_HUMAN	CACNA1I	physical	15174051
ZN232_HUMAN	ZNF232	physical	15174051
PLAG1_HUMAN	PLAG1	physical	15174051
RLF_HUMAN	RLF	physical	15174051
FETUA_HUMAN	AHSG	physical	15174051
APOC3_HUMAN	APOC3	physical	15174051
CRUM1_HUMAN	CRB1	physical	15174051
EXOC6_HUMAN	EXOC6	physical	15174051
SFR19_HUMAN	SCAF1	physical	15174051
GFAP_HUMAN	GFAP	physical	15174051
T22D1_HUMAN	TSC22D1	physical	15174051
ITB5_HUMAN	ITGB5	physical	15174051
K2C6A_HUMAN	KRT6A	physical	15174051
IC1_HUMAN	SERPING1	physical	15174051
TTPAL_HUMAN	TTPAL	physical	15174051
THRB_HUMAN	F2	physical	15174051
AP1M1_HUMAN	AP1M1	physical	15174051
AMPD3_HUMAN	AMPD3	physical	15174051
APOA2_HUMAN	APOA2	physical	15174051
APOC2_HUMAN	APOC2	physical	15174051
CHKB_HUMAN	CHKB	physical	15174051
FA7_HUMAN	F7	physical	15174051
CO4A_HUMAN	C4A	physical	15174051
CFAB_HUMAN	CFB	physical	15174051
CFAD_HUMAN	CFD	physical	15174051
CFAH_HUMAN	CFH	physical	15174051
CYTC_HUMAN	CST3	physical	15174051
DCD_HUMAN	DCD	physical	15174051
ERF1_HUMAN	ETF1	physical	15174051
GELS_HUMAN	GSN	physical	15174051
IGDC4_HUMAN	IGDCC4	physical	15174051
HEMO_HUMAN	HPX	physical	15174051
PHC3_HUMAN	PHC3	physical	15174051
F10A1_HUMAN	ST13	physical	15174051
DERL1_HUMAN	DERL1	physical	15174051
F71E2_HUMAN	FAM71E2	physical	15174051
QTRT2_HUMAN	QTRTD1	physical	15174051
K0232_HUMAN	KIAA0232	physical	15174051
ITIH1_HUMAN	ITIH1	physical	15174051
K1C13_HUMAN	KRT13	physical	15174051
K1C16_HUMAN	KRT16	physical	15174051
K2C5_HUMAN	KRT5	physical	15174051
K2C6B_HUMAN	KRT6B	physical	15174051
OBSL1_HUMAN	OBSL1	physical	15174051
CTGE5_HUMAN	CTAGE5	physical	15174051
ASPG_HUMAN	AGA	physical	15174051
NCOA3_HUMAN	NCOA3	physical	15174051
OR3A2_HUMAN	OR3A2	physical	15174051
CXCL7_HUMAN	PPBP	physical	15174051
PF4V_HUMAN	PF4V1	physical	15174051
PCDH1_HUMAN	PCDH1	physical	15174051
RBP2_HUMAN	RANBP2	physical	15174051
RYR2_HUMAN	RYR2	physical	15174051
SACS_HUMAN	SACS	physical	15174051
3BP5_HUMAN	SH3BP5	physical	15174051
PA24F_HUMAN	PLA2G4F	physical	15174051
TIAM1_HUMAN	TIAM1	physical	15174051
TRY3_HUMAN	PRSS3	physical	15174051
ZN292_HUMAN	ZNF292	physical	15174051
AP4E1_HUMAN	AP4E1	physical	15174051
APOE_HUMAN	APOE	physical	15174051
CABL1_HUMAN	CABLES1	physical	15174051
CMC2_HUMAN	SLC25A13	physical	15174051
NLRC4_HUMAN	NLRC4	physical	15174051
CLCA2_HUMAN	CLCA2	physical	15174051
DGKG_HUMAN	DGKG	physical	15174051
DMD_HUMAN	DMD	physical	15174051
DICER_HUMAN	DICER1	physical	15174051
GRAP2_HUMAN	GRAP2	physical	15174051
TPC11_HUMAN	TRAPPC11	physical	15174051
S31A7_HUMAN	SPATA31A7	physical	15174051
PZRN4_HUMAN	PDZRN4	physical	15174051
PALB2_HUMAN	PALB2	physical	15174051
LDB3_HUMAN	LDB3	physical	15174051
CEP44_HUMAN	CEP44	physical	15174051
ITA2_HUMAN	ITGA2	physical	15174051
JARD2_HUMAN	JARID2	physical	15174051
GCN1_HUMAN	GCN1L1	physical	15174051
CMTA1_HUMAN	CAMTA1	physical	15174051
SL9A8_HUMAN	SLC9A8	physical	15174051
CNOT1_HUMAN	CNOT1	physical	15174051
LAT_HUMAN	LAT	physical	15174051
MYL4_HUMAN	MYL4	physical	15174051
MYLK3_HUMAN	MYLK3	physical	15174051
TITIN_HUMAN	TTN	physical	15174051
NPHN_HUMAN	NPHS1	physical	15174051
AAAT_HUMAN	SLC1A5	physical	15174051
PEG3_HUMAN	PEG3	physical	15174051
OCTC_HUMAN	CROT	physical	15174051
BBC3B_HUMAN	BBC3	physical	15174051
BBC3_HUMAN	BBC3	physical	15174051
RANB3_HUMAN	RANBP3	physical	15174051
SCN5A_HUMAN	SCN5A	physical	15174051
SPAST_HUMAN	SPAST	physical	15174051
SLAP2_HUMAN	SLA2	physical	15174051
TR150_HUMAN	THRAP3	physical	15174051
SGO2_HUMAN	SGOL2	physical	15174051
TRY1_HUMAN	PRSS1	physical	15174051
DCC_HUMAN	DCC	physical	15174051
VINEX_HUMAN	SORBS3	physical	15174051

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615999	Hyperthyroxinemia, familial dysalbuminemic (FDAH)
616000	Analbuminemia (ANALBA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ALBU_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Nonenzymatic glycosylation of albumin in vivo. Identification ofmultiple glycosylated sites."; Iberg N., Fluckiger R.; J. Biol. Chem. 261:13542-13545(1986). Cited for: GLYCATION AT LYS-36; LYS-223; LYS-257; LYS-305; LYS-341; LYS-375;LYS-463; LYS-549 AND LYS-558.	3759977 [Abstract]
"Nonenzymatic glycosylation of human serum albumin alters itsconformation and function."; Shaklai N., Garlick R.L., Bunn H.F.; J. Biol. Chem. 259:3812-3817(1984). Cited for: GLYCATION AT LYS-549.	6706980 [Abstract]
"The principal site of nonenzymatic glycosylation of human serumalbumin in vivo."; Garlick R.L., Mazer J.S.; J. Biol. Chem. 258:6142-6146(1983). Cited for: GLYCATION AT LYS-223 AND LYS-549.	6853480 [Abstract]
"Enzymatic digestion and mass spectrometry in the study of advancedglycation end products/peptides."; Lapolla A., Fedele D., Reitano R., Arico N.C., Seraglia R., Traldi P.,Marotta E., Tonani R.; J. Am. Soc. Mass Spectrom. 15:496-509(2004). Cited for: PROTEIN SEQUENCE OF 250-264, GLYCATION AT LYS-75; LYS-161; LYS-186;LYS-249; LYS-257; LYS-300; LYS-337; LYS-347; LYS-375; LYS-402;LYS-437; LYS-468; LYS-560; LYS-549; LYS-569 AND LYS-597, LACK OFGLYCATION AT LYS-28; LYS-44; LYS-65; LYS-88; LYS-97; LYS-117; LYS-130;LYS-160; LYS-183; LYS-198; LYS-205; LYS-214; LYS-219; LYS-229;LYS-236; LYS-264; LYS-286; LYS-298; LYS-310; LYS-383; LYS-396;LYS-413; LYS-426; LYS-438; LYS-456; LYS-460; LYS-490; LYS-499;LYS-524; LYS-543; LYS-548; LYS-562; LYS-565; LYS-581; LYS-584; LYS-588AND LYS-598, AND MASS SPECTROMETRY.	15047055 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443; THR-444 ANDTHR-446, AND MASS SPECTROMETRY.	19690332 [Abstract]
"An initial characterization of the serum phosphoproteome."; Zhou W., Ross M.M., Tessitore A., Ornstein D., Vanmeter A.,Liotta L.A., Petricoin E.F. III; J. Proteome Res. 8:5523-5531(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294 AND SER-297, TISSUESPECIFICITY, AND MASS SPECTROMETRY.	19824718 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	18318008 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-164, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-108 AND TYR-164, ANDMASS SPECTROMETRY.	18083107 [Abstract]

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