PEG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEG3_HUMAN
• UniProt AC: Q9GZU2
• Protein Name: Paternally-expressed gene 3 protein
• Gene Name: PEG3
• Organism: Homo sapiens (Human).
• Sequence Length: 1588
• Subcellular Localization: Nucleus . Cytoplasm.
• Protein Description: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells..
• Protein Sequence: MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRFRNLIYVEFVGPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRAKKPENCEKLVTLLENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSDRDWDRRGRSRDMEPRDRWSHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLVQLAEDDGHSHMTQGHSSRSKRSAYPSTSRGLKTMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESVIQQRVYEGNAFRGGFRFNSTLVSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSVSSLSSLSSPSFTESQPIDFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEYGESFIHSVAVSEVQKSQVGGKRFECKDCGETFNKSAALAEHRKIHARGYLVECKNQECEEAFMPSPTFSELQKIYGKDKFYECRVCKETFLHSSALIEHQKIHFGDDKDNEREHERERERERGETFRPSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPGQSLKRRQKTYNKEKLCDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEKSVIHSGPFTESQKSHTITRPLESDEDEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASVEAQKSHSVAGPSKPKVMAESTIQSFDAINHQRVRAGGNTSEGREYSRSVIHSLVASKPPRSHNGNELVESNEKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVFRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHRSNETSVIHSLPFGEQTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIRSLAPTDPQTSYAQEQYAKEQARNKCKDFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHGQETIEDPVIQGSDMEDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKVHSRKCLVDSREYTHSVIHTHSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYSMKGCDDGFIALLPMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMAEEAIIPGLALTEFQRSQTEERLFECAVCGESFVNPAELADHVTVHKNEPYEYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEDEAAAAAAAAAQEVEANVHVPQVVLRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEAGQPNGEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEEPEGDADEPDGVGIEDPEEGEDQEIQVEEPYYDCHECTETFTSSTAFSEHLKTHASMIIFEPANAFGECSGYIERASTSTGGANQADEKYFKCDVCGQLFNDRLSLARHQNTHTG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	NLYELDSDLTKEPDV CCEECCCCCCCCCCE	59.01	27251275
30	Phosphorylation	LDSDLTKEPDVIIGE CCCCCCCCCCEEECC	41.31	27251275
125	Acetylation	VTLLENYKEMYQPED HHHHHHHHHHHCCCC	47.81	30591213
128	Phosphorylation	LENYKEMYQPEDDNN HHHHHHHHCCCCCCC	23.23	24043423
131 (in isoform 4)	Phosphorylation	-	63.57	22210691
136	Phosphorylation	QPEDDNNSDVTSDDD CCCCCCCCCCCCHHH	39.45	24043423
139	Phosphorylation	DDNNSDVTSDDDMTR CCCCCCCCCHHHHHC	31.28	24043423
140	Phosphorylation	DNNSDVTSDDDMTRN CCCCCCCCHHHHHCC	38.60	24043423
143 (in isoform 4)	Phosphorylation	-	45.39	22210691
145	Phosphorylation	VTSDDDMTRNRRESS CCCHHHHHCCCHHCC	31.61	24043423
151	Phosphorylation	MTRNRRESSPPHSVH HHCCCHHCCCCCCCC	46.46	28842319
152	Phosphorylation	TRNRRESSPPHSVHS HCCCHHCCCCCCCCC	37.38	28842319
188	Phosphorylation	SHTRNPRSRMPPRDL CCCCCCHHCCCCCCC	33.90	-
196	Phosphorylation	RMPPRDLSLPVVAKT CCCCCCCCCCEEEEE	34.61	22985185
203	Phosphorylation	SLPVVAKTSFEMDRE CCCEEEEECEECCCC	28.98	27251275
204	Phosphorylation	LPVVAKTSFEMDRED CCEEEEECEECCCCC	20.64	28348404
222	Phosphorylation	SRAYESRSQDAESYQ CHHHHHHHHHHHHHH	41.51	29116813
253 (in isoform 3)	Malonylation	-	43.34	26320211
280	Phosphorylation	HSSRSKRSAYPSTSR CCCCCCCCCCCCCCC	35.57	27794612
282	Phosphorylation	SRSKRSAYPSTSRGL CCCCCCCCCCCCCCC	10.04	24719451
284	Phosphorylation	SKRSAYPSTSRGLKT CCCCCCCCCCCCCCC	26.75	27794612
291	Phosphorylation	STSRGLKTMPEAKKS CCCCCCCCCCHHHHC	42.89	24719451
359	Phosphorylation	ISLNKRESVIQQRVY CCCCCCHHHHHHHHH	28.67	28842319
372	Methylation	VYEGNAFRGGFRFNS HHCCCCCCCCCCCCC	41.75	30988803
380	Phosphorylation	GGFRFNSTLVSRKRV CCCCCCCHHCCHHHH	32.08	-
401	Ubiquitination	YHFDTDGKGSIHDQK HCCCCCCCCCCCCCC	52.90	-
403	Phosphorylation	FDTDGKGSIHDQKGC CCCCCCCCCCCCCCC	21.89	30576142
408	Ubiquitination	KGSIHDQKGCPRKKP CCCCCCCCCCCCCCC	69.41	-
414	Ubiquitination	QKGCPRKKPFECGSE CCCCCCCCCCCCCHH	57.10	-
427	Phosphorylation	SEMRKAMSVSSLSSL HHHHHHHCHHHHHHC	24.57	28348404
429	Phosphorylation	MRKAMSVSSLSSLSS HHHHHCHHHHHHCCC	20.46	28348404
430	Phosphorylation	RKAMSVSSLSSLSSP HHHHCHHHHHHCCCC	30.07	28348404
432	Phosphorylation	AMSVSSLSSLSSPSF HHCHHHHHHCCCCCC	31.05	27251275
433	Phosphorylation	MSVSSLSSLSSPSFT HCHHHHHHCCCCCCC	37.25	28348404
435	Phosphorylation	VSSLSSLSSPSFTES HHHHHHCCCCCCCCC	41.99	28348404
436	Phosphorylation	SSLSSLSSPSFTESQ HHHHHCCCCCCCCCC	29.83	28348404
438	Phosphorylation	LSSLSSPSFTESQPI HHHCCCCCCCCCCCC	46.91	28348404
440	Phosphorylation	SLSSPSFTESQPIDF HCCCCCCCCCCCCCC	38.78	28348404
442	Phosphorylation	SSPSFTESQPIDFGA CCCCCCCCCCCCCCC	37.89	28348404
489	Phosphorylation	YGESFIHSVAVSEVQ HHHHHHHHHHHHHHH	13.62	25627689
493	Phosphorylation	FIHSVAVSEVQKSQV HHHHHHHHHHHHHHC	23.47	25159151
516	Ubiquitination	DCGETFNKSAALAEH CHHHCCCHHHHHHHH	36.96	-
547	Phosphorylation	CEEAFMPSPTFSELQ HHHHHCCCCCHHHHH	25.45	29116813
611	Phosphorylation	RGETFRPSPALNEFQ HHCCCCCCHHHHHHH	20.67	28842319
639	Phosphorylation	CGETFLHSSSLKEHQ CCCEEECCCHHHHHH	24.62	29759185
640	Phosphorylation	GETFLHSSSLKEHQK CCEEECCCHHHHHHC	29.01	29759185
641	Phosphorylation	ETFLHSSSLKEHQKI CEEECCCHHHHHHCH	46.61	29759185
671	Phosphorylation	ETFIPGQSLKRRQKT CCCCCCHHHHHHHHC	41.60	29116813
677	Acetylation	QSLKRRQKTYNKEKL HHHHHHHHCCCHHHH	51.68	19827707
721	Phosphorylation	EGRGYEKSVIHSGPF CCCCCCCCEEEECCC	17.86	21712546
725	Phosphorylation	YEKSVIHSGPFTESQ CCCCEEEECCCCCCC	36.72	21712546
734	Phosphorylation	PFTESQKSHTITRPL CCCCCCCCCEEECCC	20.44	22210691
736	Phosphorylation	TESQKSHTITRPLES CCCCCCCEEECCCCC	31.00	22210691
738	Phosphorylation	SQKSHTITRPLESDE CCCCCEEECCCCCCC	27.65	29116813
743	Phosphorylation	TITRPLESDEDEKAF EEECCCCCCCCCCCE	54.72	29116813
751	Phosphorylation	DEDEKAFTISSNPYE CCCCCCEECCCCCCC	25.47	29116813
757	Phosphorylation	FTISSNPYENQKIPT EECCCCCCCCCCCCC	31.59	29414761
784	Phosphorylation	SVIHSLASVEAQKSH HHHHHHHCHHHHHCC	26.28	28348404
809	Phosphorylation	MAESTIQSFDAINHQ EEECEECHHHHHCCC	22.65	28348404
830	Phosphorylation	NTSEGREYSRSVIHS CCCCCCHHHHHHHHH	14.18	29632367
831	Phosphorylation	TSEGREYSRSVIHSL CCCCCHHHHHHHHHH	17.21	29632367
841	Phosphorylation	VIHSLVASKPPRSHN HHHHHHHCCCCCCCC	37.91	-
866	Phosphorylation	GESSIYISDLNDKRQ CCCCEEEECCCCCCC	21.05	30631047
891	Phosphorylation	GGSKNRNYEDSVIQS CCCCCCCHHHHHHHH	20.20	30576142
894	Phosphorylation	KNRNYEDSVIQSVFR CCCCHHHHHHHHHHH	14.80	30576142
898	Phosphorylation	YEDSVIQSVFRAKPQ HHHHHHHHHHHCCCC	16.46	29978859
907	Phosphorylation	FRAKPQKSVPGEGSG HHCCCCCCCCCCCCC	28.44	29116813
934	Acetylation	SNVREYQKARAKKKY CHHHHHHHHHHHHHH	38.65	7712407
941	Phosphorylation	KARAKKKYIEHRSNE HHHHHHHHHHHCCCC	22.03	26074081
946	Phosphorylation	KKYIEHRSNETSVIH HHHHHHCCCCCCEEE	40.71	26074081
949	Phosphorylation	IEHRSNETSVIHSLP HHHCCCCCCEEEECC	32.32	26074081
950	Phosphorylation	EHRSNETSVIHSLPF HHCCCCCCEEEECCC	16.94	26074081
954	Phosphorylation	NETSVIHSLPFGEQT CCCCEEEECCCCCCC	26.98	26074081
961	Phosphorylation	SLPFGEQTFRPRGML ECCCCCCCCCCCCCE	19.80	26074081
997	Phosphorylation	IHDREKPSGSRNYEW HCCCCCCCCCCCCEE	61.54	-
1002	Phosphorylation	KPSGSRNYEWSVIRS CCCCCCCCEEEEHHH	20.05	22461510
1026	Ubiquitination	YAQEQYAKEQARNKC HHHHHHHHHHHHHHC	45.48	-
1043	Phosphorylation	FRQFFATSEDLNTNQ HHHHHHCHHHCCCCC	26.19	28348404
1058	Phosphorylation	KIYDQEKSHGEESQG CHHHHHHHCCCCCCC	35.65	28348404
1063	Phosphorylation	EKSHGEESQGENTDG HHHCCCCCCCCCCCC	38.90	28348404
1068	Phosphorylation	EESQGENTDGEETHS CCCCCCCCCCCCCCC	40.87	28348404
1073	Phosphorylation	ENTDGEETHSEETHG CCCCCCCCCCCCCCC	26.80	28348404
1141	Phosphorylation	LVDSREYTHSVIHTH EECCCCCCCEEEECC	11.70	29116813
1147	Phosphorylation	YTHSVIHTHSISEYQ CCCEEEECCCCCHHC	13.24	28348404
1149	Phosphorylation	HSVIHTHSISEYQRD CEEEECCCCCHHCCC	29.03	27251275
1163	Phosphorylation	DYTGEQLYECPKCGE CCCCCCCCCCCCCCC	18.38	-
1167	Ubiquitination	EQLYECPKCGESFIH CCCCCCCCCCCCEEC	67.54	-
1223	Phosphorylation	RNPALAGSAIRCLLC HCHHHHHHHHHHHHH	18.21	29457462
1311	Phosphorylation	HKNEPYEYGSSYTHT ECCCCCCCCCCCCCC	19.23	28348404
1313	Phosphorylation	NEPYEYGSSYTHTSF CCCCCCCCCCCCCCC	21.19	28348404
1314	Phosphorylation	EPYEYGSSYTHTSFL CCCCCCCCCCCCCCC	29.68	28348404
1315	Phosphorylation	PYEYGSSYTHTSFLT CCCCCCCCCCCCCCC	12.30	28348404
1316	Phosphorylation	YEYGSSYTHTSFLTE CCCCCCCCCCCCCCC	22.18	28348404
1318	Phosphorylation	YGSSYTHTSFLTEPL CCCCCCCCCCCCCCC	17.24	28348404
1319	Phosphorylation	GSSYTHTSFLTEPLK CCCCCCCCCCCCCCC	15.62	28348404
1322	Phosphorylation	YTHTSFLTEPLKGAI CCCCCCCCCCCCCCC	33.28	28348404
1340	Phosphorylation	ECKDCGKSFIHSTVL ECCCCCCCHHHHHHH	18.08	29116813
1551	Phosphorylation	GYIERASTSTGGANQ CEEEECCCCCCCCCC	29.35	29414761

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIAH2_HUMAN	SIAH2	physical	10681424
SIAH1_HUMAN	SIAH1	physical	10681424
PEG3_HUMAN	PEG3	physical	23936039

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.