UniProt ID | GRAP2_HUMAN | |
---|---|---|
UniProt AC | O75791 | |
Protein Name | GRB2-related adapter protein 2 | |
Gene Name | GRAP2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 330 | |
Subcellular Localization | Nucleus . Cytoplasm . Endosome . | |
Protein Description | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.. | |
Protein Sequence | MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
36 | Ubiquitination | SNQEEWFKAELGSQE CCCHHHHHHHHCCCC | 41.86 | - | |
41 | Phosphorylation | WFKAELGSQEGYVPK HHHHHHCCCCCCCCC | 37.37 | 29978859 | |
45 | Phosphorylation | ELGSQEGYVPKNFID HHCCCCCCCCCCEEE | 16.90 | 15570572 | |
48 | Ubiquitination | SQEGYVPKNFIDIQF CCCCCCCCCEEEEEC | 55.22 | - | |
57 | Ubiquitination | FIDIQFPKWFHEGLS EEEEECCHHHCCCHH | 64.87 | - | |
85 | Phosphorylation | GFFIIRASQSSPGDF EEEEEEECCCCCCCE | 22.27 | 23186163 | |
87 | Phosphorylation | FIIRASQSSPGDFSI EEEEECCCCCCCEEE | 35.68 | 29978859 | |
88 | Phosphorylation | IIRASQSSPGDFSIS EEEECCCCCCCEEEE | 25.84 | 23186163 | |
93 | Phosphorylation | QSSPGDFSISVRHED CCCCCCEEEEEECCC | 20.77 | 23186163 | |
95 | Phosphorylation | SPGDFSISVRHEDDV CCCCEEEEEECCCCC | 16.35 | 23186163 | |
106 | Acetylation | EDDVQHFKVMRDNKG CCCCCEEEEEECCCC | 32.75 | 19608861 | |
112 | Ubiquitination | FKVMRDNKGNYFLWT EEEEECCCCCEEEEE | 53.47 | - | |
121 | Ubiquitination | NYFLWTEKFPSLNKL CEEEEECCCCCHHHH | 56.02 | - | |
127 | Ubiquitination | EKFPSLNKLVDYYRT CCCCCHHHHHHHHHH | 56.00 | - | |
131 | Phosphorylation | SLNKLVDYYRTNSIS CHHHHHHHHHHCCHH | 6.33 | 22798277 | |
132 | Phosphorylation | LNKLVDYYRTNSISR HHHHHHHHHHCCHHH | 13.39 | 28509920 | |
134 | Phosphorylation | KLVDYYRTNSISRQK HHHHHHHHCCHHHCC | 19.73 | 28509920 | |
136 | Phosphorylation | VDYYRTNSISRQKQI HHHHHHCCHHHCCEE | 22.71 | 28509920 | |
138 | Phosphorylation | YYRTNSISRQKQIFL HHHHCCHHHCCEEEE | 28.60 | 22798277 | |
141 | Ubiquitination | TNSISRQKQIFLRDR HCCHHHCCEEEECCC | 44.22 | - | |
159 | Phosphorylation | DQGHRGNSLDRRSQG CCCCCCCCCCCHHCC | 34.18 | 30576142 | |
164 | Phosphorylation | GNSLDRRSQGGPHLS CCCCCCHHCCCCCCC | 33.79 | 28634120 | |
171 | Phosphorylation | SQGGPHLSGAVGEEI HCCCCCCCCCCCCCC | 22.98 | 28111955 | |
181 | Phosphorylation | VGEEIRPSMNRKLSD CCCCCCHHHCCCCCC | 20.88 | - | |
187 | Phosphorylation | PSMNRKLSDHPPTLP HHHCCCCCCCCCCCC | 36.59 | 23401153 | |
192 | Phosphorylation | KLSDHPPTLPLQQHQ CCCCCCCCCCCCCCC | 45.52 | 28796482 | |
207 | Phosphorylation | HQPQPPQYAPAPQQL CCCCCCCCCCCCHHH | 21.96 | 28796482 | |
222 | Phosphorylation | QQPPQQRYLQHHHFH CCCCHHHHHHHHCCC | 13.33 | 28796482 | |
233 | Methylation | HHFHQERRGGSLDIN HCCCCHHCCCCCCCC | 53.74 | - | |
236 | Phosphorylation | HQERRGGSLDINDGH CCHHCCCCCCCCCCC | 26.20 | 23401153 | |
246 | Phosphorylation | INDGHCGTGLGSEMN CCCCCCCCCCCHHHH | 34.33 | 23401153 | |
250 | Phosphorylation | HCGTGLGSEMNAALM CCCCCCCHHHHHHHH | 38.42 | 28464451 | |
262 | Phosphorylation | ALMHRRHTDPVQLQA HHHHCCCCCHHHHHH | 39.94 | 23401153 | |
324 | Phosphorylation | LGLFPANYVAPMTR- CCCCCCHHCCCCCC- | 10.49 | 23917254 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GRAP2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GRAP2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GRAP2_HUMAN !! |
Kegg Disease | ||||||
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There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Acetylation | |
Reference | PubMed |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-106, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-45 AND THR-262, AND MASSSPECTROMETRY. | |
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262, AND MASSSPECTROMETRY. | |
"Profiling of tyrosine phosphorylation pathways in human cells usingmass spectrometry."; Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.; Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262, AND MASSSPECTROMETRY. | |
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-45, AND MASSSPECTROMETRY. |