BEND5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BEND5_HUMAN
• UniProt AC: Q7L4P6
• Protein Name: BEN domain-containing protein 5
• Gene Name: BEND5
• Organism: Homo sapiens (Human).
• Sequence Length: 421
• Protein Description: Acts as a transcriptional repressor. [PubMed: 23468431]
• Protein Sequence: MYAFVRFLEDNVCYALPVSCVRDFSPRSRLDFDNQKVYAVYRGPEELGAGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPVMDKYILDNGKVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPLSPHKLSIVRECLYDRIAQETVDETEIAQRLSKVNKYICEKIMDINKSCKNEERREAKYNLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	DFDNQKVYAVYRGPE CCCCCEEEEEEECHH	9.44	26074081
41	Phosphorylation	NQKVYAVYRGPEELG CCEEEEEEECHHHCC	11.15	26074081
53	Phosphorylation	ELGAGPESPPRAPRD HCCCCCCCCCCCCCC	43.25	28464451
96	Phosphorylation	KIKIPKLSLNHVEED CCCCCCCCCCCEECC	33.00	-
126	Acetylation	IKRPEGRKPSEVAHK CCCCCCCCCCHHHHH	64.85	25953088
128	Phosphorylation	RPEGRKPSEVAHKSI CCCCCCCCHHHHHHH	47.97	18785766
133	Acetylation	KPSEVAHKSIEAVVA CCCHHHHHHHHHHHH	43.31	19608861
172	Phosphorylation	PGTEDMDSLEDAVVP CCCCCHHHHHHCHHH	27.33	-
258	Sumoylation	AIDLEKVKSECLEPE CCCHHHHHHHHCCCC	52.16	28112733
311	Ubiquitination	GIWVDEEKWHQLQVT CEEECHHHEEEEEEE	48.18	-
361	Phosphorylation	AVPKPPLSPHKLSIV CCCCCCCCHHHHHHH	30.63	28348404
366	Phosphorylation	PLSPHKLSIVRECLY CCCHHHHHHHHHHHH	24.68	24719451
417	Acetylation	NEERREAKYNLQ--- CHHHHHHHHCCC---	29.89	12439301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BEND5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BEND5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BEND5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
F161A_HUMAN	FAM161A	physical	25416956
VPS25_HUMAN	VPS25	physical	25416956
ZGPAT_HUMAN	ZGPAT	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
LCE1B_HUMAN	LCE1B	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, AND MASS SPECTROMETRY.
PubMed: 19608861