TNFL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNFL6_HUMAN
• UniProt AC: P48023
• Protein Name: Tumor necrosis factor ligand superfamily member 6
• Gene Name: FASLG
• Organism: Homo sapiens (Human).
• Sequence Length: 281
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes w
• Protein Description: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. [PubMed: 26334989]
• Protein Sequence: MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	S-palmitoylation	GNHSTGLCLLVMFFM CCHHHHHHHHHHHHH	2.67	21368861
135	Phosphorylation	EKQIGHPSPPPEKKE HHHHCCCCCCCCHHH	44.35	21964256
184	N-linked_Glycosylation	KKGGLVINETGLYFV EECCEEECCCCCEEE	33.04	UniProtKB CARBOHYD
184	N-linked_Glycosylation	KKGGLVINETGLYFV EECCEEECCCCCEEE	33.04	9405425
208	Phosphorylation	SCNNLPLSHKVYMRN CCCCCCCCCEEEECC	21.23	23532336
212	Phosphorylation	LPLSHKVYMRNSKYP CCCCCEEEECCCCCC	8.65	23532336
231	Phosphorylation	MMEGKMMSYCTTGQM EECCEEHHHCCHHHH	17.35	23312004
232	Phosphorylation	MEGKMMSYCTTGQMW ECCEEHHHCCHHHHH	3.95	23312004
234	Phosphorylation	GKMMSYCTTGQMWAR CEEHHHCCHHHHHHH	26.23	-
250	N-linked_Glycosylation	SYLGAVFNLTSADHL HHHHHHHCCCCCCEE	35.49	UniProtKB CARBOHYD
250	N-linked_Glycosylation	SYLGAVFNLTSADHL HHHHHHHCCCCCCEE	35.49	9405425
260	N-linked_Glycosylation	SADHLYVNVSELSLV CCCEEEEEHHHEEEE	20.31	UniProtKB CARBOHYD
260	N-linked_Glycosylation	SADHLYVNVSELSLV CCCEEEEEHHHEEEE	20.31	9405425

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNFL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNFL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNFL6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TR10B_HUMAN	TNFRSF10B	physical	15659383
TNR1A_HUMAN	TNFRSF1A	physical	15659383
FADD_HUMAN	FADD	physical	12887920
CASP8_HUMAN	CASP8	physical	12887920
TNR6_HUMAN	FAS	physical	12887920
FNBP1_HUMAN	FNBP1	physical	12023017
PACN2_HUMAN	PACSIN2	physical	12023017
GRB2_HUMAN	GRB2	physical	12023017
FINC_HUMAN	FN1	physical	11276204
FYN_HUMAN	FYN	physical	11741599
GRB2_HUMAN	GRB2	physical	11741599
LCK_HUMAN	LCK	physical	11741599
TNR1A_HUMAN	TNFRSF1A	physical	12753742
TNR6_HUMAN	FAS	physical	12753742
FADD_HUMAN	FADD	physical	12753742
CASP8_HUMAN	CASP8	physical	12753742
LYN_HUMAN	LYN	physical	19807924
OSTF1_HUMAN	OSTF1	physical	19807924
SNX33_HUMAN	SNX33	physical	19807924
HCK_HUMAN	HCK	physical	19807924
NCK1_HUMAN	NCK1	physical	19807924
YES_HUMAN	YES1	physical	19807924
SRC_HUMAN	SRC	physical	19807924
SNX9_HUMAN	SNX9	physical	19807924
SRGP1_HUMAN	SRGAP1	physical	19807924
SPD2B_HUMAN	SH3PXD2B	physical	19807924
BTK_HUMAN	BTK	physical	19807924
ES8L3_HUMAN	EPS8L3	physical	19807924
RHG09_HUMAN	ARHGAP9	physical	19807924
MYO15_HUMAN	MYO15A	physical	19807924
NCK2_HUMAN	NCK2	physical	19807924
FYB1_HUMAN	FYB	physical	19807924
TEC_HUMAN	TEC	physical	19807924
SPTA1_HUMAN	SPTA1	physical	19807924
SAMN1_HUMAN	SAMSN1	physical	19807924
SH3R2_HUMAN	SH3RF2	physical	19807924
DLG2_HUMAN	DLG2	physical	19807924
VINEX_HUMAN	SORBS3	physical	19807924
SKAP2_HUMAN	SKAP2	physical	19807924
CRK_HUMAN	CRK	physical	19807924
SPN90_HUMAN	NCKIPSD	physical	19807924
SPD2A_HUMAN	SH3PXD2A	physical	19807924
BI2L1_HUMAN	BAIAP2L1	physical	19807924
SH3G3_HUMAN	SH3GL3	physical	19807924
ZO3_HUMAN	TJP3	physical	19807924
CACB3_HUMAN	CACNB3	physical	19807924
MPP4_HUMAN	MPP4	physical	19807924
PK3CA_HUMAN	PIK3CA	physical	19807924
DNMBP_HUMAN	DNMBP	physical	19807924
DOCK4_HUMAN	DOCK4	physical	19807924
KALRN_HUMAN	KALRN	physical	19807924
MACC1_HUMAN	MACC1	physical	19807924
SRGP3_HUMAN	SRGAP3	physical	19807924
FYN_HUMAN	FYN	physical	19807924
MIA_HUMAN	MIA	physical	19807924
SRGP2_HUMAN	SRGAP2	physical	19807924
ITSN2_HUMAN	ITSN2	physical	19807924
NCF1_HUMAN	NCF1	physical	19807924
ITK_HUMAN	ITK	physical	19807924
CACB4_HUMAN	CACNB4	physical	19807924
RIM3C_HUMAN	RIMBP3C	physical	19807924
SNX18_HUMAN	SNX18	physical	19807924
TNR6_HUMAN	FAS	physical	21803845
FADD_HUMAN	FADD	physical	21803845
CFLAR_HUMAN	CFLAR	physical	21803845
CASP8_HUMAN	CASP8	physical	21803845
TRIP6_HUMAN	TRIP6	physical	25416956
RGS20_HUMAN	RGS20	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
SNX9_HUMAN	SNX9	physical	26186194
CLPX_HUMAN	CLPX	physical	26186194
SC65_HUMAN	P3H4	physical	26186194
ANM2_HUMAN	PRMT2	physical	26186194
SNX33_HUMAN	SNX33	physical	26186194
E2AK1_HUMAN	EIF2AK1	physical	26186194
P3H3_HUMAN	LEPREL2	physical	26186194
MSPD2_HUMAN	MOSPD2	physical	26186194
P85A_HUMAN	PIK3R1	physical	25241761
FYN_HUMAN	FYN	physical	25241761
FINC_HUMAN	FN1	physical	25241761
ANM2_HUMAN	PRMT2	physical	28514442
E2AK1_HUMAN	EIF2AK1	physical	28514442
SNX33_HUMAN	SNX33	physical	28514442
MSPD2_HUMAN	MOSPD2	physical	28514442
P3H3_HUMAN	LEPREL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00108: Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) d
• OMIM Disease
• 601859: Autoimmune lymphoproliferative syndrome 1B (ALPS1B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.