FYB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FYB1_HUMAN
• UniProt AC: O15117
• Protein Name: FYN-binding protein 1 {ECO:0000244|HGNC:HGNC:4036}
• Gene Name: FYB1 {ECO:0000244|HGNC:HGNC:4036}
• Organism: Homo sapiens (Human).
• Sequence Length: 783
• Subcellular Localization: Cytoplasm . Nucleus. Cell junction .
• Protein Description: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton..
• Protein Sequence: MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGNASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKYNTGGNP -----CCCCCCCCCC		19608861
3	Ubiquitination	-----MAKYNTGGNP -----CCCCCCCCCC		24816145
4	Phosphorylation	----MAKYNTGGNPT ----CCCCCCCCCCC		29978859
6	Phosphorylation	--MAKYNTGGNPTED --CCCCCCCCCCCCC		28270605
11	Phosphorylation	YNTGGNPTEDVSVNS CCCCCCCCCCCCCCC		28270605
13	Ubiquitination	TGGNPTEDVSVNSRP CCCCCCCCCCCCCCC		24816145
15	Phosphorylation	GNPTEDVSVNSRPFR CCCCCCCCCCCCCCE		28270605
18	Phosphorylation	TEDVSVNSRPFRVTG CCCCCCCCCCCEEEC		28270605
28	Phosphorylation	FRVTGPNSSSGIQAR CEEECCCCCCCHHHH		21082442
30	Phosphorylation	VTGPNSSSGIQARKN EECCCCCCCHHHHHH		-
46	Phosphorylation	FNNQGNASPPAGPSN HCCCCCCCCCCCCCC		23401153
52	Phosphorylation	ASPPAGPSNVPKFGS CCCCCCCCCCCCCCC		26074081
59	Phosphorylation	SNVPKFGSPKPPVAV CCCCCCCCCCCCCCC		24719451
69	Phosphorylation	PPVAVKPSSEEKPDK CCCCCCCCCCCCCCC		30576142
94	Phosphorylation	GAGQRFGTPASLTTR CCCCCCCCCCCCCCC		28122231
97	Phosphorylation	QRFGTPASLTTRDPE CCCCCCCCCCCCCCC		27535140
111	Acetylation	EAKVGFLKPVGPKPI CCCCCCEECCCCCCC		23749302
111	Ubiquitination	EAKVGFLKPVGPKPI CCCCCCEECCCCCCC		29967540
121	Ubiquitination	GPKPINLPKEDSKPT CCCCCCCCCCCCCCC		29967540
149	Acetylation	VNQDHDLKPLGPKSG CCCCCCCCCCCCCCC		19608861
155	Phosphorylation	LKPLGPKSGPTPPTS CCCCCCCCCCCCCCC		28060719
158	Phosphorylation	LGPKSGPTPPTSENE CCCCCCCCCCCCHHH		30576142
159	Acetylation	GPKSGPTPPTSENEQ CCCCCCCCCCCHHHH		19608861
161	O-linked_Glycosylation	KSGPTPPTSENEQKQ CCCCCCCCCHHHHHH		29351928
161	Phosphorylation	KSGPTPPTSENEQKQ CCCCCCCCCHHHHHH		18491316
162	O-linked_Glycosylation	SGPTPPTSENEQKQA CCCCCCCCHHHHHHH		29351928
167	Ubiquitination	PTSENEQKQAFPKLT CCCHHHHHHHCCHHH		29967540
177	Ubiquitination	FPKLTGVKGKFMSAS CCHHHCCCCCCCCCC		29967540
179	Acetylation	KLTGVKGKFMSASQD HHHCCCCCCCCCCCC		23749302
182	Phosphorylation	GVKGKFMSASQDLEP CCCCCCCCCCCCCCC		24850871
184	Phosphorylation	KGKFMSASQDLEPKP CCCCCCCCCCCCCCC		23684312
205	Phosphorylation	FGQKPPLSTENSHED CCCCCCCCCCCCCCC		23401153
206	Phosphorylation	GQKPPLSTENSHEDE CCCCCCCCCCCCCCC		28450419
209	Phosphorylation	PPLSTENSHEDESPM CCCCCCCCCCCCCCC		22617229
214	Phosphorylation	ENSHEDESPMKNVSS CCCCCCCCCCCCCCC		30576142
220	Phosphorylation	ESPMKNVSSSKGSPA CCCCCCCCCCCCCCC		28450419
221	Phosphorylation	SPMKNVSSSKGSPAP CCCCCCCCCCCCCCC		28450419
222	Phosphorylation	PMKNVSSSKGSPAPL CCCCCCCCCCCCCCC		28450419
223	Ubiquitination	MKNVSSSKGSPAPLG CCCCCCCCCCCCCCC		-
225	Phosphorylation	NVSSSKGSPAPLGVR CCCCCCCCCCCCCCC		23401153
233	Phosphorylation	PAPLGVRSKSGPLKP CCCCCCCCCCCCCCC		26074081
235	Phosphorylation	PLGVRSKSGPLKPAR CCCCCCCCCCCCCCC		26657352
245	Phosphorylation	LKPAREDSENKDHAG CCCCCCCCCCCCCCC		26074081
255	Phosphorylation	KDHAGEISSLPFPGV CCCCCCCCCCCCCCE		28857561
256	Phosphorylation	DHAGEISSLPFPGVV CCCCCCCCCCCCCEE		28857561
265	Acetylation	PFPGVVLKPAASRGG CCCCEEEECCHHHCC		19608861
269	Phosphorylation	VVLKPAASRGGPGLS EEEECCHHHCCCCCC		27251275
275	Acetylation	ASRGGPGLSKNGEEK HHHCCCCCCCCCCHH		19608861
282	Acetylation	LSKNGEEKKEDRKID CCCCCCHHHHHHHHH		25953088
283	Ubiquitination	SKNGEEKKEDRKIDA CCCCCHHHHHHHHHH		24816145
287	Ubiquitination	EEKKEDRKIDAAKNT CHHHHHHHHHHHHHH		-
292	Ubiquitination	DRKIDAAKNTFQSKI HHHHHHHHHHHHHHH		29967540
293	Ubiquitination	RKIDAAKNTFQSKIN HHHHHHHHHHHHHHC		24816145
298	Ubiquitination	AKNTFQSKINQEELA HHHHHHHHHCHHHHH		24816145
302	Ubiquitination	FQSKINQEELASGTP HHHHHCHHHHHCCCC		29967540
306	Phosphorylation	INQEELASGTPPARF HCHHHHHCCCCCCCC		28450419
308	Phosphorylation	QEELASGTPPARFPK HHHHHCCCCCCCCCC		28464451
308	Ubiquitination	QEELASGTPPARFPK HHHHHCCCCCCCCCC		24816145
318	Phosphorylation	ARFPKAPSKLTVGGP CCCCCCCCCEEECCC		26074081
319	Acetylation	RFPKAPSKLTVGGPW CCCCCCCCEEECCCC		25953088
319	Ubiquitination	RFPKAPSKLTVGGPW CCCCCCCCEEECCCC		29967540
321	Phosphorylation	PKAPSKLTVGGPWGQ CCCCCCEEECCCCCC		26074081
329	Phosphorylation	VGGPWGQSQEKEKGD ECCCCCCCCCCCCCC		23401153
329	Ubiquitination	VGGPWGQSQEKEKGD ECCCCCCCCCCCCCC		29967540
334	Acetylation	GQSQEKEKGDKNSAT CCCCCCCCCCCCCCC		7822933
373	Ubiquitination	VDLTKFHKTSSGNST CCCCEEEECCCCCCC		29967540
374	O-linked_Glycosylation	DLTKFHKTSSGNSTS CCCEEEECCCCCCCC		29351928
374	Phosphorylation	DLTKFHKTSSGNSTS CCCEEEECCCCCCCC		-
383	Ubiquitination	SGNSTSKGQTSYSTT CCCCCCCCCCCCCCC		29967540
385	Phosphorylation	NSTSKGQTSYSTTSL CCCCCCCCCCCCCCC		28796482
386	Phosphorylation	STSKGQTSYSTTSLP CCCCCCCCCCCCCCC		28796482
387	Phosphorylation	TSKGQTSYSTTSLPP CCCCCCCCCCCCCCC		28796482
388	Phosphorylation	SKGQTSYSTTSLPPP CCCCCCCCCCCCCCC		28796482
389	Phosphorylation	KGQTSYSTTSLPPPP CCCCCCCCCCCCCCC		28796482
390	Phosphorylation	GQTSYSTTSLPPPPP CCCCCCCCCCCCCCC		28796482
391	Phosphorylation	QTSYSTTSLPPPPPS CCCCCCCCCCCCCCC		28796482
398	Phosphorylation	SLPPPPPSHPASQPP CCCCCCCCCCCCCCC		25394399
418	Phosphorylation	PSQPPVPSLPPRNIK CCCCCCCCCCCCCCC		24719451
425	Acetylation	SLPPRNIKPPFDLKS CCCCCCCCCCCCCCC		19608861
432	Phosphorylation	KPPFDLKSPVNEDNQ CCCCCCCCCCCCCCC		28464451
435	Acetylation	FDLKSPVNEDNQDGV CCCCCCCCCCCCCCC		19608861
443	Phosphorylation	EDNQDGVTHSDGAGN CCCCCCCCCCCCCCC		26657352
445	Phosphorylation	NQDGVTHSDGAGNLD CCCCCCCCCCCCCCC		28796482
457	Phosphorylation	NLDEEQDSEGETYED CCCHHCCCCCCCHHH		23401153
461	Phosphorylation	EQDSEGETYEDIEAS HCCCCCCCHHHHHHH		28122231
462	Phosphorylation	QDSEGETYEDIEASK CCCCCCCHHHHHHHH		28796482
468	Phosphorylation	TYEDIEASKEREKKR CHHHHHHHHHHHHHH		26074081
496	Ubiquitination	EQKEKEKKEQEIKKK HHHHHHHHHHHHHHH		-
503	Ubiquitination	KEQEIKKKFKLTGPI HHHHHHHHHCCCCCC		-
505	Acetylation	QEIKKKFKLTGPIQV HHHHHHHCCCCCCHH		25953088
507	Phosphorylation	IKKKFKLTGPIQVIH HHHHHCCCCCCHHHH		30576142
530	Phosphorylation	KGGKNELSFKQGEQI CCCCCCEEECCCCEE		24719451
549	Acetylation	ITDNPEGKWLGRTAR EECCCCCCEECCCCC		25953088
549	Ubiquitination	ITDNPEGKWLGRTAR EECCCCCCEECCCCC		29967540
554	Phosphorylation	EGKWLGRTARGSYGY CCCEECCCCCCCCCE		23312004
558	Phosphorylation	LGRTARGSYGYIKTT ECCCCCCCCCEEEEE		23401153
559	Phosphorylation	GRTARGSYGYIKTTA CCCCCCCCCEEEEEE		28796482
559	Ubiquitination	GRTARGSYGYIKTTA CCCCCCCCCEEEEEE		29967540
561	Phosphorylation	TARGSYGYIKTTAVE CCCCCCCEEEEEEEE		28060719
564	Phosphorylation	GSYGYIKTTAVEIDY CCCCEEEEEEEEECH		26356563
565	Phosphorylation	SYGYIKTTAVEIDYD CCCEEEEEEEEECHH		26356563
571	Phosphorylation	TTAVEIDYDSLKLKK EEEEEECHHHHCCCC		19605366
573	Phosphorylation	AVEIDYDSLKLKKDS EEEECHHHHCCCCCC		23401153
575	Ubiquitination	EIDYDSLKLKKDSLG EECHHHHCCCCCCCC		29967540
580	Phosphorylation	SLKLKKDSLGAPSRP HHCCCCCCCCCCCCC		26074081
585	Ubiquitination	KDSLGAPSRPIEDDQ CCCCCCCCCCCCCCH		29967540
595	Phosphorylation	IEDDQEVYDDVAEQD CCCCHHHHHHHHHHC		10409671
625	Phosphorylation	PPPDDDIYDGIEEED CCCCCCCCCCCCHHC		-
645 (in isoform 2)	Phosphorylation	-		27251275
647 (in isoform 2)	Phosphorylation	-		27251275
651	Phosphorylation	LDMGDEVYDDVDTSD CCCCCCCCCCCCCCC		10409671
665 (in isoform 2)	Phosphorylation	-		24719451
673 (in isoform 2)	Phosphorylation	-		26657352
675 (in isoform 2)	Phosphorylation	-		26657352
675 (in isoform 3)	Phosphorylation	-		24719451
681 (in isoform 2)	Phosphorylation	-		28348404
682 (in isoform 2)	Phosphorylation	-		28348404
685 (in isoform 3)	Phosphorylation	-		26657352
692 (in isoform 3)	Phosphorylation	-		28348404
700	Acetylation	KDFRKKFKYDGEIRV HHHHHHHCCCCEEEE		25953088
701	Phosphorylation	DFRKKFKYDGEIRVL HHHHHHCCCCEEEEE		-
709	Phosphorylation	DGEIRVLYSTKVTTS CCEEEEEEEEEEEEE		-
711	Phosphorylation	EIRVLYSTKVTTSIT EEEEEEEEEEEEEEC		19413330
714	Phosphorylation	VLYSTKVTTSITSKK EEEEEEEEEEECCCC		28060719
715	Phosphorylation	LYSTKVTTSITSKKW EEEEEEEEEECCCCC		28060719
716	Phosphorylation	YSTKVTTSITSKKWG EEEEEEEEECCCCCC		28060719
720	Acetylation	VTTSITSKKWGTRDL EEEEECCCCCCCCEE		25953088
730	Ubiquitination	GTRDLQVKPGESLEV CCCEEEECCCCCEEE		29967540
734	Phosphorylation	LQVKPGESLEVIQTT EEECCCCCEEEEEEC		28464451
745	Ubiquitination	IQTTDDTKVLCRNEE EEECCCCEEEEECCC		29967540
754	Ubiquitination	LCRNEEGKYGYVLRS EEECCCCCCEEEEEE		24816145
755	Phosphorylation	CRNEEGKYGYVLRSY EECCCCCCEEEEEEE		28796482
757	Phosphorylation	NEEGKYGYVLRSYLA CCCCCCEEEEEEEEC		28796482
761	Phosphorylation	KYGYVLRSYLADNDG CCEEEEEEEECCCCC		26552605
762	Phosphorylation	YGYVLRSYLADNDGE CEEEEEEEECCCCCC		26552605
764	Ubiquitination	YVLRSYLADNDGEIY EEEEEEECCCCCCCC		24816145
771	Phosphorylation	ADNDGEIYDDIADGC CCCCCCCCCCCCCCC		28796482
776	Ubiquitination	EIYDDIADGCIYDND CCCCCCCCCCCCCCC		29967540
780	Phosphorylation	DIADGCIYDND---- CCCCCCCCCCC----		28796482
786	Ubiquitination	IYDND---------- CCCCC----------		29967540
791	Ubiquitination	--------------- ---------------		29967540
800	Ubiquitination	------------------------ ------------------------		24816145
801	Ubiquitination	------------------------- -------------------------		29967540
810	Ubiquitination	---------------------------------- ----------------------------------		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
559	Y	Phosphorylation	Kinase	FYN	P06241	PSP
571	Y	Phosphorylation	Kinase	FYN	P06241	PSP
595	Y	Phosphorylation	Kinase	FYN	P06241	PSP
625	Y	Phosphorylation	Kinase	FYN	P06241	PSP
651	Y	Phosphorylation	Kinase	FYN	P06241	PSP
755	Y	Phosphorylation	Kinase	FYN	P06241	PSP
757	Y	Phosphorylation	Kinase	FYN	P06241	PSP
771	Y	Phosphorylation	Kinase	FYN	P06241	PSP
780	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FYB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FYB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKAP1_HUMAN	SKAP1	physical	9748251
SKAP1_HUMAN	SKAP1	physical	9671755
VASP_HUMAN	VASP	physical	10747096
BCL10_HUMAN	BCL10	physical	20164171
CAR11_HUMAN	CARD11	physical	20164171
M3K7_HUMAN	MAP3K7	physical	20164171
FYN_HUMAN	FYN	physical	9207119
LCP2_HUMAN	LCP2	physical	9207119
FYN_HUMAN	FYN	physical	25814554
LCP2_HUMAN	LCP2	physical	25814554
NCK2_HUMAN	NCK2	physical	25814554
UBC9_HUMAN	UBE2I	physical	29127148

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.