dbPTM

LCP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LCP2_HUMAN
UniProt AC	Q13094
Protein Name	Lymphocyte cytosolic protein 2
Gene Name	LCP2
Organism	Homo sapiens (Human).
Sequence Length	533
Subcellular Localization	Cytoplasm .
Protein Description	Involved in T-cell antigen receptor mediated signaling..
Protein Sequence	MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	DPDSLADYFKKLNYK CHHHHHHHHHHCCHH	16.22	21082442
29	Phosphorylation	DYFKKLNYKDCEKAV HHHHHCCHHHHHHHH	20.74	-
30	Ubiquitination	YFKKLNYKDCEKAVK HHHHCCHHHHHHHHH	55.62	-
39	Phosphorylation	CEKAVKKYHIDGARF HHHHHHHHCCCHHHH	9.78	-
59	Ubiquitination	NDIQKFPKLRVPILS HHHHHCCCCHHHHHH	52.65	24816145
80	Phosphorylation	NKNEERRSIFTRKPQ HCCHHHHHHHHCCCC	28.42	30576142
106	Phosphorylation	EEDNGGWSSFEEDDY CCCCCCCCCCCCCCC	28.55	-
107	Phosphorylation	EDNGGWSSFEEDDYE CCCCCCCCCCCCCCC	30.12	-
113	Phosphorylation	SSFEEDDYESPNDDQ CCCCCCCCCCCCCCC	30.54	17148460
128	Phosphorylation	DGEDDGDYESPNEEE CCCCCCCCCCCCCCC	24.68	17148460
130	Phosphorylation	EDDGDYESPNEEEEA CCCCCCCCCCCCCCC	27.14	17353368
145	Phosphorylation	PVEDDADYEPPPSND CCCCCCCCCCCCCCC	31.86	17148460
169	Phosphorylation	PAKPFPNSNSMYIDR CCCCCCCCCCCEECC	30.44	-
171	Phosphorylation	KPFPNSNSMYIDRPP CCCCCCCCCEECCCC	16.88	-
173	Phosphorylation	FPNSNSMYIDRPPSG CCCCCCCEECCCCCC	10.25	16094384
207	Phosphorylation	PPAGRNHSPLPPPQT CCCCCCCCCCCCCCC	31.51	23401153
214	Phosphorylation	SPLPPPQTNHEEPSR CCCCCCCCCCCCCCC	44.29	26074081
220	Phosphorylation	QTNHEEPSRSRNHKT CCCCCCCCCCCCCCC	46.28	26074081
222	Phosphorylation	NHEEPSRSRNHKTAK CCCCCCCCCCCCCCC	41.60	-
227	Phosphorylation	SRSRNHKTAKLPAPS CCCCCCCCCCCCCCC	22.82	-
229	Acetylation	SRNHKTAKLPAPSID CCCCCCCCCCCCCCC	61.30	25953088
234	Phosphorylation	TAKLPAPSIDRSTKP CCCCCCCCCCCCCCC	38.95	21949786
240	Ubiquitination	PSIDRSTKPPLDRSL CCCCCCCCCCCCCCC	45.98	24816145
246	Phosphorylation	TKPPLDRSLAPFDRE CCCCCCCCCCCCCCC	28.66	-
256	Phosphorylation	PFDREPFTLGKKPPF CCCCCCCCCCCCCCC	45.37	28060719
260	Acetylation	EPFTLGKKPPFSDKP CCCCCCCCCCCCCCC	57.00	25953088
260	Ubiquitination	EPFTLGKKPPFSDKP CCCCCCCCCCCCCCC	57.00	-
264	Phosphorylation	LGKKPPFSDKPSIPA CCCCCCCCCCCCCCC	50.96	-
268	Phosphorylation	PPFSDKPSIPAGRSL CCCCCCCCCCCCCCH	47.12	-
273	Methylation	KPSIPAGRSLGEHLP CCCCCCCCCHHHCCC	30.71	115386307
274	Phosphorylation	PSIPAGRSLGEHLPK CCCCCCCCHHHCCCC	39.55	-
297	Phosphorylation	TTERHERSSPLPGKK CCCCCCCCCCCCCCC	33.07	26657352
298	Phosphorylation	TERHERSSPLPGKKP CCCCCCCCCCCCCCC	36.36	23401153
338	Phosphorylation	QPALLPMSSNTFPSR CCCEEECCCCCCCCC	20.63	30108239
339	Phosphorylation	PALLPMSSNTFPSRS CCEEECCCCCCCCCC	33.37	30108239
341	Phosphorylation	LLPMSSNTFPSRSTK EEECCCCCCCCCCCC	38.58	28787133
344	Phosphorylation	MSSNTFPSRSTKPSP CCCCCCCCCCCCCCC	34.37	30108239
367	Phosphorylation	MPGAFSESNSSFPQS CCCCCCCCCCCCCCC	40.59	26074081
369	Phosphorylation	GAFSESNSSFPQSAS CCCCCCCCCCCCCCC	42.51	26074081
370	Phosphorylation	AFSESNSSFPQSASL CCCCCCCCCCCCCCC	45.24	26074081
374	Phosphorylation	SNSSFPQSASLPPYF CCCCCCCCCCCCCCC	21.77	26074081
376	Phosphorylation	SSFPQSASLPPYFSQ CCCCCCCCCCCCCCC	46.81	26074081
380	Phosphorylation	QSASLPPYFSQGPSN CCCCCCCCCCCCCCC	17.58	26074081
382	Phosphorylation	ASLPPYFSQGPSNRP CCCCCCCCCCCCCCC	28.52	26074081
386	Phosphorylation	PYFSQGPSNRPPIRA CCCCCCCCCCCCCCC	52.90	26074081
392	Methylation	PSNRPPIRAEGRNFP CCCCCCCCCCCCCCC	32.15	115386315
410	Phosphorylation	PNKPRPPSPAEEENS CCCCCCCCCHHHCCC	39.15	28348404
417	Phosphorylation	SPAEEENSLNEEWYV CCHHHCCCCCCCEEE	35.53	28464451
423	Phosphorylation	NSLNEEWYVSYITRP CCCCCCEEEEEECCH	5.25	8702662
425	Phosphorylation	LNEEWYVSYITRPEA CCCCEEEEEECCHHH	8.63	-
426	Phosphorylation	NEEWYVSYITRPEAE CCCEEEEEECCHHHH	9.03	8702662
428	Phosphorylation	EWYVSYITRPEAEAA CEEEEEECCHHHHHH	31.75	-
438	Ubiquitination	EAEAALRKINQDGTF HHHHHHHHHCCCCCE	47.03	29967540
454	Phosphorylation	VRDSSKKTTTNPYVL EECCCCCCCCCCEEE	42.46	25907765
455	Phosphorylation	RDSSKKTTTNPYVLM ECCCCCCCCCCEEEE	33.19	25907765
456	Phosphorylation	DSSKKTTTNPYVLMV CCCCCCCCCCEEEEE	39.15	25907765
459	Phosphorylation	KKTTTNPYVLMVLYK CCCCCCCEEEEEEEC	14.32	25907765
465	Phosphorylation	PYVLMVLYKDKVYNI CEEEEEEECCCEEEE	13.01	25907765
470	Phosphorylation	VLYKDKVYNIQIRYQ EEECCCEEEEEEEEE	16.58	-
476	Phosphorylation	VYNIQIRYQKESQVY EEEEEEEEECCCEEE	26.09	-
483	Phosphorylation	YQKESQVYLLGTGLR EECCCEEEEECCCCC	6.64	-
492	Ubiquitination	LGTGLRGKEDFLSVS ECCCCCCCCCCCCHH	47.91	29967540
507	Ubiquitination	DIIDYFRKMPLLLID HHHHHHHCCCEEEEC	34.66	24816145
516	Ubiquitination	PLLLIDGKNRGSRYQ CEEEECCCCCCCCCE	39.46	29967540
522	Phosphorylation	GKNRGSRYQCTLTHA CCCCCCCCEEEEECC	15.05	-
532	Phosphorylation	TLTHAAGYP------ EEECCCCCC------	10.88	25839225

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
113	Y	Phosphorylation	Kinase	SYK	P43405	PSP
113	Y	Phosphorylation	Kinase	LCK	P06239	PSP
113	Y	Phosphorylation	Kinase	SYK	Q15046	PhosphoELM
113	Y	Phosphorylation	Kinase	ZAP70	P43403	PSP
128	Y	Phosphorylation	Kinase	SYK	P43405	PSP
128	Y	Phosphorylation	Kinase	LCK	P06239	PSP
128	Y	Phosphorylation	Kinase	SYK	Q15046	PhosphoELM
128	Y	Phosphorylation	Kinase	ZAP70	P43403	PSP
145	Y	Phosphorylation	Kinase	LCK	P06239	PSP
145	Y	Phosphorylation	Kinase	TXK	P42681	PhosphoELM
145	Y	Phosphorylation	Kinase	ZAP70	P43403	PSP
173	Y	Phosphorylation	Kinase	ITK	Q08881	PSP
376	S	Phosphorylation	Kinase	MAP4K1	Q92918	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LCP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LCP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRAP2_HUMAN	GRAP2	physical	16189514
P85A_HUMAN	PIK3R1	physical	15388330
ITK_HUMAN	ITK	physical	15388330
NCK1_HUMAN	NCK1	physical	15388330
PLCG1_HUMAN	PLCG1	physical	11390650
LYN_HUMAN	LYN	physical	10026222
PHAG1_HUMAN	PAG1	physical	10790433
TRAT1_HUMAN	TRAT1	physical	10790433
CBL_HUMAN	CBL	physical	10204582
GRB2_HUMAN	GRB2	physical	10204582
FYB1_MOUSE	Fyb	physical	10497204
GRAP2_HUMAN	GRAP2	physical	10021361
GRAP2_HUMAN	GRAP2	genetic	10021361
GRAP2_HUMAN	GRAP2	physical	10224278
GRB2_HUMAN	GRB2	physical	10224278
CBL_HUMAN	CBL	physical	9716598
GRB2_HUMAN	GRB2	physical	9716598
SHC1_HUMAN	SHC1	physical	9716598
GRAP2_HUMAN	GRAP2	physical	12176364
GRB2_HUMAN	GRB2	physical	12176364
FYB1_HUMAN	FYB	physical	9207119
A4_HUMAN	APP	physical	21832049
PLCG1_HUMAN	PLCG1	physical	16467851
YBOX1_HUMAN	YBX1	physical	21988832
NCK2_HUMAN	NCK2	physical	25416956
GRAP2_HUMAN	GRAP2	physical	25416956
FXR2_HUMAN	FXR2	physical	25416956
STAM2_HUMAN	STAM2	physical	25416956
GRAP2_HUMAN	GRAP2	physical	21516116
FXR2_HUMAN	FXR2	physical	21516116
ACK1_HUMAN	TNK2	physical	28188290
FYB1_HUMAN	FYB	physical	29127148

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LCP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry."; Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.; Nat. Methods 2:591-598(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-173 AND SER-207, ANDMASS SPECTROMETRY.	16094384 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, AND MASSSPECTROMETRY.	15144186 [Abstract]