FYB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FYB1_MOUSE
• UniProt AC: O35601
• Protein Name: FYN-binding protein 1
• Gene Name: Fyb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 819
• Subcellular Localization: Cytoplasm. Nucleus. Cell junction . Colocalizes with TMEM47 at cell-cell contacts in podocytes.
• Protein Description: May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2..
• Protein Sequence: MAKFNTGSNPTEEAATSSRPFKVAGQSSPSGIQSRKNLFDNQGNASPPAGPSSMPKFGTTKPPLAAKPTYEEKPEKEPKPPFLKPTGGSPRFGTQPNSVSRDPEVKVGFLKPVSPKPTSLTKEDSKPVVLRPPGNKLHNLNQESDLKTPGPKPGPAPPVPENELKPGFSKVAGAKSKFMPAAQDTDSKPRFPRHTFGQKPSLSTEDSQEENTSKNVPVQKGSPVQLGAKSKGAPFKPPKEDPEDKDHGAPSSPFPGVVLKPAASRGSPGLSKNFEEKKEDRKTDLAKNIFLNKLNQEEPARFPKAPSKLTAGTPWGQSQEKEGDKNSATPKQKALPPLSVLGPPPPKPNRPPNVDLTRFRKADSANSATKSQTPYSTTSLPPPPPTHPASQPPLPASHPAHPPVPSLPPRNIKPPLDLKHPINDENQDGVMHSDGTGNLEEEQESEGETYEDIDSSKERDKKREKEEKKRLELERKEQKEREKKEQELKKKFKLTGPIQVIHHAKACCDVKGGKNELSFKQGEDIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKRKKNSLNAVPPRLVEDDQDVYDDVAEQDAPNSHGQSGSGGMFPPPPTDDEIYDGIEEEDDDDGSVPQVDEKTNAWSWGILKMLKGKDDRKKSIREKPKVSESDNNEGSSLPSQHKQLDVGEEVYDDVDASDFPPPPAEMSQGMSVGRAKTEEKDPKKLKKQEKEEKDLRKKFKYDGEIRVLYSTKVASSLTSKKWGARDLQIKPGESLEVIQSTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKFNTGSNP -----CCCCCCCCCC		-
11	Phosphorylation	FNTGSNPTEEAATSS CCCCCCCCHHHHHCC		25266776
16	Phosphorylation	NPTEEAATSSRPFKV CCCHHHHHCCCCEEE		25367039
17	Phosphorylation	PTEEAATSSRPFKVA CCHHHHHCCCCEEEC		25367039
18	Phosphorylation	TEEAATSSRPFKVAG CHHHHHCCCCEEECC		25367039
27	Phosphorylation	PFKVAGQSSPSGIQS CEEECCCCCCCCCHH		23527152
28	Phosphorylation	FKVAGQSSPSGIQSR EEECCCCCCCCCHHH		25521595
30	Phosphorylation	VAGQSSPSGIQSRKN ECCCCCCCCCHHHHC		28833060
34	Phosphorylation	SSPSGIQSRKNLFDN CCCCCCHHHHCCCCC		28833060
46	Phosphorylation	FDNQGNASPPAGPSS CCCCCCCCCCCCCCC		22942356
52	Phosphorylation	ASPPAGPSSMPKFGT CCCCCCCCCCCCCCC		28285833
53	Phosphorylation	SPPAGPSSMPKFGTT CCCCCCCCCCCCCCC		28285833
86	Phosphorylation	KPPFLKPTGGSPRFG CCCCCCCCCCCCCCC		22817900
89	Phosphorylation	FLKPTGGSPRFGTQP CCCCCCCCCCCCCCC		29472430
114	Phosphorylation	VGFLKPVSPKPTSLT EEEECCCCCCCCCCC		26824392
118	Phosphorylation	KPVSPKPTSLTKEDS CCCCCCCCCCCCCCC		25159016
119	Phosphorylation	PVSPKPTSLTKEDSK CCCCCCCCCCCCCCC		25159016
121	Phosphorylation	SPKPTSLTKEDSKPV CCCCCCCCCCCCCCE		25159016
195	Phosphorylation	KPRFPRHTFGQKPSL CCCCCCCCCCCCCCC		25619855
201	Phosphorylation	HTFGQKPSLSTEDSQ CCCCCCCCCCCCCCC		27742792
203	Phosphorylation	FGQKPSLSTEDSQEE CCCCCCCCCCCCCCC		26824392
204	Phosphorylation	GQKPSLSTEDSQEEN CCCCCCCCCCCCCCC		27742792
207	Phosphorylation	PSLSTEDSQEENTSK CCCCCCCCCCCCCCC		25619855
212	Phosphorylation	EDSQEENTSKNVPVQ CCCCCCCCCCCCCCC		25619855
213	Phosphorylation	DSQEENTSKNVPVQK CCCCCCCCCCCCCCC		25619855
222	Phosphorylation	NVPVQKGSPVQLGAK CCCCCCCCCCCCCCC		26824392
251	Phosphorylation	DKDHGAPSSPFPGVV CCCCCCCCCCCCCEE		30387612
252	Phosphorylation	KDHGAPSSPFPGVVL CCCCCCCCCCCCEEE		27600695
264	Phosphorylation	VVLKPAASRGSPGLS EEEECCHHCCCCCCC		22817900
267	Phosphorylation	KPAASRGSPGLSKNF ECCHHCCCCCCCCCH		28285833
318	Phosphorylation	AGTPWGQSQEKEGDK CCCCCCCCCCCCCCC		24719451
367	Phosphorylation	RKADSANSATKSQTP EECCCCCCCCCCCCC		-
371	Phosphorylation	SANSATKSQTPYSTT CCCCCCCCCCCCCCC		25367039
373	Phosphorylation	NSATKSQTPYSTTSL CCCCCCCCCCCCCCC		25367039
375	Phosphorylation	ATKSQTPYSTTSLPP CCCCCCCCCCCCCCC		25367039
376	Phosphorylation	TKSQTPYSTTSLPPP CCCCCCCCCCCCCCC		25367039
377	Phosphorylation	KSQTPYSTTSLPPPP CCCCCCCCCCCCCCC		25367039
378	Phosphorylation	SQTPYSTTSLPPPPP CCCCCCCCCCCCCCC		25367039
379	Phosphorylation	QTPYSTTSLPPPPPT CCCCCCCCCCCCCCC		25367039
386	Phosphorylation	SLPPPPPTHPASQPP CCCCCCCCCCCCCCC		25367039
390	Phosphorylation	PPPTHPASQPPLPAS CCCCCCCCCCCCCCC		25367039
397	Phosphorylation	SQPPLPASHPAHPPV CCCCCCCCCCCCCCC		25367039
433	Phosphorylation	NQDGVMHSDGTGNLE CCCCCCCCCCCCCCH		25159016
436	Phosphorylation	GVMHSDGTGNLEEEQ CCCCCCCCCCCHHHH		25159016
445	Phosphorylation	NLEEEQESEGETYED CCHHHHHHCCCCHHH		25521595
449	Phosphorylation	EQESEGETYEDIDSS HHHHCCCCHHHCCCH		25159016
450	Phosphorylation	QESEGETYEDIDSSK HHHCCCCHHHCCCHH		25159016
455	Phosphorylation	ETYEDIDSSKERDKK CCHHHCCCHHHHHHH		25777480
456	Phosphorylation	TYEDIDSSKERDKKR CHHHCCCHHHHHHHH		25777480
495	Phosphorylation	LKKKFKLTGPIQVIH HHHHHCCCCCCEEEE		27600695
511	Acetylation	AKACCDVKGGKNELS CEEHHCCCCCCCEEE		15605871
542	Phosphorylation	EGKWLGRTARGSYGY CCCEECCCCCCCCCE		25266776
546	Phosphorylation	LGRTARGSYGYIKTT ECCCCCCCCCEEEEE		28833060
547	Phosphorylation	GRTARGSYGYIKTTA CCCCCCCCCEEEEEE		28833060
559	Phosphorylation	TTAVEIDYDSLKRKK EEEEEECHHHHHHHH		21082442
561	Phosphorylation	AVEIDYDSLKRKKNS EEEECHHHHHHHHCC		26824392
568	Phosphorylation	SLKRKKNSLNAVPPR HHHHHHCCCCCCCCC		22942356
647	Acetylation	WGILKMLKGKDDRKK HHHHHHHCCCCHHHH		15611585
655	Phosphorylation	GKDDRKKSIREKPKV CCCHHHHHHHHCCCC		24719451
663	Phosphorylation	IREKPKVSESDNNEG HHHCCCCCCCCCCCC		26824392
665	Phosphorylation	EKPKVSESDNNEGSS HCCCCCCCCCCCCCC		29472430
671	Phosphorylation	ESDNNEGSSLPSQHK CCCCCCCCCCCHHHC		30635358
672	Phosphorylation	SDNNEGSSLPSQHKQ CCCCCCCCCCHHHCC		25367039
675	Phosphorylation	NEGSSLPSQHKQLDV CCCCCCCHHHCCCCC		30635358
687	Phosphorylation	LDVGEEVYDDVDASD CCCCCHHHCCCCHHH		22817900
770	Phosphorylation	LQIKPGESLEVIQST CEECCCCCEEEEEEC		25266776
791	Phosphorylation	CRNEEGKYGYVLRSY EECCCCCCEEEEEEE		22817900
793	Phosphorylation	NEEGKYGYVLRSYLV CCCCCCEEEEEEEEE		28725479
807	Phosphorylation	VDNDGEIYDDIADGC ECCCCCEEECCCCCC		22817900
816	Phosphorylation	DIADGCIYDND---- CCCCCCCCCCC----		30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FYB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FYB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FYB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC9_MOUSE	Ube2i	physical	29127148

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.