TRAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRAT1_HUMAN
• UniProt AC: Q6PIZ9
• Protein Name: T-cell receptor-associated transmembrane adapter 1
• Gene Name: TRAT1
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Subcellular Localization: Cell membrane ; Single-pass type III membrane protein .
• Protein Description: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells..
• Protein Sequence: MSGISGCPFFLWGLLALLGLALVISLIFNISHYVEKQRQDKMYSYSSDHTRVDEYYIEDTPIYGNLDDMISEPMDENCYEQMKARPEKSVNKMQEATPSAQATNETQMCYASLDHSVKGKRRKPRKQNTHFSDKDGDEQLHAIDASVSKTTLVDSFSPESQAVEENIHDDPIRLFGLIRAKREPIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	KQRQDKMYSYSSDHT HHHHHCCCCCCCCCC	15.36	28796482
44	Phosphorylation	QRQDKMYSYSSDHTR HHHHCCCCCCCCCCC	18.29	27080861
45	Phosphorylation	RQDKMYSYSSDHTRV HHHCCCCCCCCCCCE	8.49	27080861
46	Phosphorylation	QDKMYSYSSDHTRVD HHCCCCCCCCCCCEE	24.29	28796482
47	Phosphorylation	DKMYSYSSDHTRVDE HCCCCCCCCCCCEEE	25.77	28796482
50	Phosphorylation	YSYSSDHTRVDEYYI CCCCCCCCCEEEEEE	37.06	27080861
79	Phosphorylation	EPMDENCYEQMKARP CCCCCCHHHHHHHCC	22.30	9687533
92	Ubiquitination	RPEKSVNKMQEATPS CCHHHHHHHHHHCCC	39.54	-
97	Phosphorylation	VNKMQEATPSAQATN HHHHHHHCCCCCCCC	19.61	29978859
99	Phosphorylation	KMQEATPSAQATNET HHHHHCCCCCCCCCH	28.76	29978859
103	Phosphorylation	ATPSAQATNETQMCY HCCCCCCCCCHHHHH	22.85	30576142
106	Phosphorylation	SAQATNETQMCYASL CCCCCCCHHHHHHHC	24.55	30576142
110	Phosphorylation	TNETQMCYASLDHSV CCCHHHHHHHCCCCC	8.22	28122231
112	Phosphorylation	ETQMCYASLDHSVKG CHHHHHHHCCCCCCC	14.09	23401153
116	Phosphorylation	CYASLDHSVKGKRRK HHHHCCCCCCCCCCC	25.78	23401153
129	Phosphorylation	RKPRKQNTHFSDKDG CCCCCCCCCCCCCCH	23.08	29978859
132	Phosphorylation	RKQNTHFSDKDGDEQ CCCCCCCCCCCHHHH	35.83	29978859
146	Phosphorylation	QLHAIDASVSKTTLV HHHHEEEECCCCEEC	24.15	30576142
148	Phosphorylation	HAIDASVSKTTLVDS HHEEEECCCCEECCC	23.07	30576142
149	Ubiquitination	AIDASVSKTTLVDSF HEEEECCCCEECCCC	43.29	-
150	Phosphorylation	IDASVSKTTLVDSFS EEEECCCCEECCCCC	20.18	28122231
151	Phosphorylation	DASVSKTTLVDSFSP EEECCCCEECCCCCH	28.64	28122231
155	Phosphorylation	SKTTLVDSFSPESQA CCCEECCCCCHHHHH	21.83	28122231
157	Phosphorylation	TTLVDSFSPESQAVE CEECCCCCHHHHHHH	31.54	28122231
160	Phosphorylation	VDSFSPESQAVEENI CCCCCHHHHHHHHHC	27.16	28122231
160	O-linked_Glycosylation	VDSFSPESQAVEENI CCCCCHHHHHHHHHC	27.16	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HRSL4_HUMAN	RARRES3	physical	22607805
1433E_HUMAN	YWHAE	physical	22607805

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.