dbPTM

SKAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SKAP1_HUMAN
UniProt AC	Q86WV1
Protein Name	Src kinase-associated phosphoprotein 1
Gene Name	SKAP1
Organism	Homo sapiens (Human).
Sequence Length	359
Subcellular Localization	Cytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Protein Description	Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells..
Protein Sequence	MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSLVGIVPKEYLTTAFEVEER

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	DAPFLSDYQDEGMED CCCCCCCCCCCCHHH	17.94	-
110	Ubiquitination	QELDNVIKQGYLEKK HHHHHHHHHCHHCHH	33.13	-
110	Acetylation	QELDNVIKQGYLEKK HHHHHHHHHCHHCHH	33.13	7226439
141	Phosphorylation	VVSRGLFYYYANEKS EEECCEEEECCCCCC	10.70	-
142	Phosphorylation	VSRGLFYYYANEKSK EECCEEEECCCCCCC	6.70	25147952
143	Phosphorylation	SRGLFYYYANEKSKQ ECCEEEECCCCCCCC	7.50	-
152	Acetylation	NEKSKQPKGTFLIKG CCCCCCCCCEEEEEE	69.00	28734743
173	Acetylation	PHLRRDSKKESCFEL CHHCCCCCCCCCEEC	65.92	28734751
174	Acetylation	HLRRDSKKESCFELT HHCCCCCCCCCEECC	59.83	28734759
176	Phosphorylation	RRDSKKESCFELTSQ CCCCCCCCCEECCCC	32.74	28972365
181	Phosphorylation	KESCFELTSQDRRSY CCCCEECCCCCCCEE	19.69	28972365
219	Phosphorylation	LSSLTIPYEEDEEEE HHHCCCCCCCCCCHH	28.27	11909961
232	Phosphorylation	EEEKEETYDDIDGFD HHHHHHHCCCCCCCC	18.20	11909961
240	Phosphorylation	DDIDGFDSPSCGSQC CCCCCCCCCCCCCCC	19.22	26074081
242	Phosphorylation	IDGFDSPSCGSQCRP CCCCCCCCCCCCCCC	34.75	26074081
245	Phosphorylation	FDSPSCGSQCRPTIL CCCCCCCCCCCCCCC	30.36	26074081
250	Phosphorylation	CGSQCRPTILPGSVG CCCCCCCCCCCCCCC	18.78	26074081
255	Phosphorylation	RPTILPGSVGIKEPT CCCCCCCCCCCCCCC	18.41	26074081
259	Ubiquitination	LPGSVGIKEPTEEKE CCCCCCCCCCCCCCC	52.27	-
262	Phosphorylation	SVGIKEPTEEKEEED CCCCCCCCCCCCHHH	58.84	28796482
271	Phosphorylation	EKEEEDIYEVLPDEE CCCHHHHHHHCCCCC	16.59	12171928
295	Phosphorylation	TRRKGVDYASYYQGL CCCCCCCHHHHHCCC	8.61	16461356
298	Phosphorylation	KGVDYASYYQGLWDC CCCCHHHHHCCCCCC	7.52	16461356
299	Phosphorylation	GVDYASYYQGLWDCH CCCHHHHHCCCCCCC	8.13	25147952
314	Phosphorylation	GDQPDELSFQRGDLI CCCCCCCCCCCCHHH	19.79	24719451
325	Phosphorylation	GDLIRILSKEYNMYG CHHHHHHHHHCCCCC	22.52	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
219	Y	Phosphorylation	Kinase	FYN	P06241	PhosphoELM
232	Y	Phosphorylation	Kinase	FYN	P06241	PSP
271	Y	Phosphorylation	Kinase	FYN	P06241	Uniprot
295	Y	Phosphorylation	Kinase	FYN	P06241	Uniprot
298	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SKAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SKAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTPRC_HUMAN	PTPRC	physical	11909961
SKAP1_HUMAN	SKAP1	physical	12171928
GRB2_HUMAN	GRB2	physical	12171928
A4_HUMAN	APP	physical	21832049
BLCAP_HUMAN	BLCAP	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
PRAM_HUMAN	PRAM1	physical	25416956
F102A_HUMAN	FAM102A	physical	25416956
AP3M1_HUMAN	AP3M1	physical	26186194
MYO9B_HUMAN	MYO9B	physical	26186194
MYO9A_HUMAN	MYO9A	physical	26186194
RPA2_HUMAN	POLR1B	physical	26186194
REXO5_HUMAN	LOC81691	physical	26186194
EMAL3_HUMAN	EML3	physical	26186194
WRN_HUMAN	WRN	physical	26186194
ASPM_HUMAN	ASPM	physical	26186194
JPH1_HUMAN	JPH1	physical	26186194
RPA1_HUMAN	POLR1A	physical	26186194
RPC1_HUMAN	POLR3A	physical	26186194
RECQ4_HUMAN	RECQL4	physical	26186194
HPS3_HUMAN	HPS3	physical	26186194
Z324A_HUMAN	ZNF324	physical	26186194
TASOR_HUMAN	FAM208A	physical	26186194
UXT_HUMAN	UXT	physical	26186194
CNDD3_HUMAN	NCAPD3	physical	26186194
MYCB2_HUMAN	MYCBP2	physical	26186194
CUL2_HUMAN	CUL2	physical	26186194
PI51A_HUMAN	PIP5K1A	physical	26186194
NEK1_HUMAN	NEK1	physical	26186194
PKHH3_HUMAN	PLEKHH3	physical	26186194
PHLB3_HUMAN	PHLDB3	physical	26186194
PK3C3_HUMAN	PIK3C3	physical	26186194
SEC63_HUMAN	SEC63	physical	26186194
SKAP2_HUMAN	SKAP2	physical	26186194
TF3C1_HUMAN	GTF3C1	physical	26186194
RMP_HUMAN	URI1	physical	26186194
P85B_HUMAN	PIK3R2	physical	26186194
P55G_HUMAN	PIK3R3	physical	26186194
RPOM_HUMAN	POLRMT	physical	26186194
PLD2_HUMAN	PLD2	physical	26186194
UCKL1_HUMAN	UCKL1	physical	26186194
PR14L_HUMAN	PRR14L	physical	26186194
KSR1_HUMAN	KSR1	physical	26186194
BCD1_HUMAN	ZNHIT6	physical	26186194
PDRG1_HUMAN	PDRG1	physical	26186194
SETX_HUMAN	SETX	physical	26186194
NFL_HUMAN	NEFL	physical	26186194
ALMS1_HUMAN	ALMS1	physical	26186194
APBP2_HUMAN	APPBP2	physical	26186194
UTP15_HUMAN	UTP15	physical	26186194
SENP5_HUMAN	SENP5	physical	26186194
CNDH2_HUMAN	NCAPH2	physical	26186194
PAX3_HUMAN	PAX3	physical	26186194
TBL2_HUMAN	TBL2	physical	26186194
ZNHI2_HUMAN	ZNHIT2	physical	26186194
ZN644_HUMAN	ZNF644	physical	26186194
SUCHY_HUMAN	SUGCT	physical	26186194
PKN3_HUMAN	PKN3	physical	26186194
TTF2_HUMAN	TTF2	physical	26186194
PPHLN_HUMAN	PPHLN1	physical	26186194
NPHP4_HUMAN	NPHP4	physical	26186194
MTMR1_HUMAN	MTMR1	physical	26186194
PKN2_HUMAN	PKN2	physical	26186194
CU002_HUMAN	C21orf2	physical	26186194
DPOLA_HUMAN	POLA1	physical	26186194
RPC2_HUMAN	POLR3B	physical	26186194
RPAB5_HUMAN	POLR2L	physical	26186194
CP110_HUMAN	CCP110	physical	26186194
SETD5_HUMAN	SETD5	physical	26186194
ELP3_HUMAN	ELP3	physical	26186194
DOCK7_HUMAN	DOCK7	physical	26186194
UBP54_HUMAN	USP54	physical	26186194
RPA49_HUMAN	POLR1E	physical	26186194
TRM44_HUMAN	TRMT44	physical	26186194
NEK4_HUMAN	NEK4	physical	26186194
ATX2_HUMAN	ATXN2	physical	26186194
MTMR5_HUMAN	SBF1	physical	26186194
GTPB6_HUMAN	GTPBP6	physical	26186194
TRM1_HUMAN	TRMT1	physical	26186194
RPA34_HUMAN	CD3EAP	physical	26186194
PER1_HUMAN	PER1	physical	26186194
SPT6H_HUMAN	SUPT6H	physical	26186194
MCM8_HUMAN	MCM8	physical	26186194
RTEL1_HUMAN	RTEL1	physical	26186194
TIGD5_HUMAN	TIGD5	physical	26186194
PUSL1_HUMAN	PUSL1	physical	26186194
KLDC3_HUMAN	KLHDC3	physical	26186194
SKAP2_HUMAN	SKAP2	physical	28514442
PAX3_HUMAN	PAX3	physical	28514442
NEK1_HUMAN	NEK1	physical	28514442
PKN3_HUMAN	PKN3	physical	28514442
SUCHY_HUMAN	SUGCT	physical	28514442
PK3C3_HUMAN	PIK3C3	physical	28514442
CU002_HUMAN	C21orf2	physical	28514442
NPHP4_HUMAN	NPHP4	physical	28514442
KSR1_HUMAN	KSR1	physical	28514442
RECQ4_HUMAN	RECQL4	physical	28514442
RPA49_HUMAN	POLR1E	physical	28514442
CP110_HUMAN	CCP110	physical	28514442
KLDC3_HUMAN	KLHDC3	physical	28514442
MTMR5_HUMAN	SBF1	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
RPA1_HUMAN	POLR1A	physical	28514442
SETD5_HUMAN	SETD5	physical	28514442
TASOR_HUMAN	FAM208A	physical	28514442
WRN_HUMAN	WRN	physical	28514442
RPA2_HUMAN	POLR1B	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
REXO5_HUMAN	LOC81691	physical	28514442
RPC1_HUMAN	POLR3A	physical	28514442
APBP2_HUMAN	APPBP2	physical	28514442
ZNHI2_HUMAN	ZNHIT2	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
UBP54_HUMAN	USP54	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
Z324A_HUMAN	ZNF324	physical	28514442
PHLB3_HUMAN	PHLDB3	physical	28514442
PKHH3_HUMAN	PLEKHH3	physical	28514442
RMP_HUMAN	URI1	physical	28514442
TTF2_HUMAN	TTF2	physical	28514442
EMAL3_HUMAN	EML3	physical	28514442
ALMS1_HUMAN	ALMS1	physical	28514442
MTMR1_HUMAN	MTMR1	physical	28514442
PR14L_HUMAN	PRR14L	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442
MYO9B_HUMAN	MYO9B	physical	28514442
RTEL1_HUMAN	RTEL1	physical	28514442
BCD1_HUMAN	ZNHIT6	physical	28514442
MYO9A_HUMAN	MYO9A	physical	28514442
P85B_HUMAN	PIK3R2	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
MA7D1_HUMAN	MAP7D1	physical	28514442
FYB1_HUMAN	FYB	physical	29127148

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SKAP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-271, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-142, AND MASSSPECTROMETRY.	18083107 [Abstract]