dbPTM

PTPRC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PTPRC_HUMAN
UniProt AC	P08575
Protein Name	Receptor-type tyrosine-protein phosphatase C {ECO:0000305}
Gene Name	PTPRC {ECO:0000312\|HGNC:HGNC:9666}
Organism	Homo sapiens (Human).
Sequence Length	1306
Subcellular Localization	Membrane Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts.
Protein Description	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity)..
Protein Sequence	MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	O-linked_Glycosylation	SDPLPTHTTAFSPAS CCCCCCCCCCCCCCH	12.22	OGP
78	N-linked_Glycosylation	ETTTSLSPDNTSTQV CCCCCCCCCCCCCCC	39.04	UniProtKB CARBOHYD
80	N-linked_Glycosylation	TTSLSPDNTSTQVSP CCCCCCCCCCCCCCH	24.09	-
90	N-linked_Glycosylation	TQVSPDSLDNASAFN CCCCHHHCCCCCCCC	40.88	UniProtKB CARBOHYD
92	N-linked_Glycosylation	VSPDSLDNASAFNTT CCHHHCCCCCCCCCC	39.38	-
95	N-linked_Glycosylation	DSLDNASAFNTTGVS HHCCCCCCCCCCCCC	36.13	UniProtKB CARBOHYD
97	N-linked_Glycosylation	LDNASAFNTTGVSSV CCCCCCCCCCCCCCC	36.37	-
106	O-linked_Glycosylation	TGVSSVQTPHLPTHA CCCCCCCCCCCCCCC	48.07	OGP
119	O-linked_Glycosylation	HADSQTPSAGTDTQT CCCCCCCCCCCCCCC	28.58	OGP
126	O-linked_Glycosylation	SAGTDTQTFSGSAAN CCCCCCCCCCCCHHC	34.91	OGP
139	O-linked_Glycosylation	ANAKLNPTPGSNAIS HCCCCCCCCCCCCCC	35.69	OGP
151	Phosphorylation	AISDVPGERSTASTF CCCCCCCCCCCCCCC	24.83	19690332
154	Phosphorylation	DVPGERSTASTFPTD CCCCCCCCCCCCCCC	30.57	19690332
162	Phosphorylation	ASTFPTDPVSPLTTT CCCCCCCCCCCCHHH	21.41	19690332
167	O-linked_Glycosylation	TDPVSPLTTTLSLAH CCCCCCCHHHHHHHC	14.76	OGP
176	O-linked_Glycosylation	TLSLAHHSSAALPAR HHHHHCCCCCCCCCC	18.94	OGP
177	O-linked_Glycosylation	LSLAHHSSAALPART HHHHCCCCCCCCCCC	18.94	OGP
184	N-linked_Glycosylation	SAALPARTSNTTITA CCCCCCCCCCCEEEE	40.40	UniProtKB CARBOHYD
185	O-linked_Glycosylation	AALPARTSNTTITAN CCCCCCCCCCEEEEC	21.24	27655845
186	N-linked_Glycosylation	ALPARTSNTTITANT CCCCCCCCCEEEECC	22.15	-
187	O-linked_Glycosylation	LPARTSNTTITANTS CCCCCCCCEEEECCC	3.01	27655845
190	N-linked_Glycosylation	RTSNTTITANTSDAY CCCCCEEEECCCCCC	31.31	UniProtKB CARBOHYD
192	N-linked_Glycosylation	SNTTITANTSDAYLN CCCEEEECCCCCCCC	21.76	-
193	O-linked_Glycosylation	NTTITANTSDAYLNA CCEEEECCCCCCCCC	36.87	27655845
194	O-linked_Glycosylation	TTITANTSDAYLNAS CEEEECCCCCCCCCC	15.52	27655845
197	N-linked_Glycosylation	TANTSDAYLNASETT EECCCCCCCCCCCCE	28.83	UniProtKB CARBOHYD
199	N-linked_Glycosylation	NTSDAYLNASETTTL CCCCCCCCCCCCEEE	34.11	-
217	O-linked_Glycosylation	GSAVISTTTIATTPS CCEEEEEEEEECCCC	2.77	OGP
218	O-linked_Glycosylation	SAVISTTTIATTPSK CEEEEEEEEECCCCC	11.88	OGP
221	O-linked_Glycosylation	ISTTTIATTPSKPTC EEEEEEECCCCCCCC	35.68	OGP
222	O-linked_Glycosylation	STTTIATTPSKPTCD EEEEEECCCCCCCCC	49.53	OGP
232	N-linked_Glycosylation	KPTCDEKYANITVDY CCCCCHHHCCEEEEE	27.63	19349973
234	N-linked_Glycosylation	TCDEKYANITVDYLY CCCHHHCCEEEEEEE	13.71	19349973
240	N-linked_Glycosylation	ANITVDYLYNKETKL CCEEEEEEECCCCCE	32.85	19349973
260	N-linked_Glycosylation	NVNENVECGNNTCTN CCCCCCCCCCCCCCC	52.90	UniProtKB CARBOHYD
262	N-linked_Glycosylation	NENVECGNNTCTNNE CCCCCCCCCCCCCCC	25.38	-
270	N-linked_Glycosylation	NTCTNNEVHNLTECK CCCCCCCEECCCCCC	54.56	UniProtKB CARBOHYD
272	N-linked_Glycosylation	CTNNEVHNLTECKNA CCCCCEECCCCCCCC	44.66	-
276	N-linked_Glycosylation	EVHNLTECKNASVSI CEECCCCCCCCEEEE	49.45	19349973
278	N-linked_Glycosylation	HNLTECKNASVSISH ECCCCCCCCEEEEEC	26.28	19349973
278	Phosphorylation	HNLTECKNASVSISH ECCCCCCCCEEEEEC	26.28	-
284	N-linked_Glycosylation	KNASVSISHNSCTAP CCCEEEEECCCCCCC	31.80	19349973
286	N-linked_Glycosylation	ASVSISHNSCTAPDK CEEEEECCCCCCCCC	4.58	19349973
314	Ubiquitination	QLHDCTQVEKADTTI ECCCCCEEECCCEEE	53.35	-
322	Ubiquitination	EKADTTICLKWKNIE ECCCEEEEEEECCEE	52.27	-
324	Ubiquitination	ADTTICLKWKNIETF CCEEEEEEECCEEEE	46.60	-
335	N-linked_Glycosylation	IETFTCDTQNITYRF EEEEEECCCCEEEEE	30.57	19349973
337	N-linked_Glycosylation	TFTCDTQNITYRFQC EEEECCCCEEEEEEE	19.05	19349973
345	Sulfoxidation	ITYRFQCGNMIFDNK EEEEEEECCEEECCC	1.64	21406390
350	Ubiquitination	QCGNMIFDNKEIKLE EECCEEECCCEEEEC	63.76	-
364	Ubiquitination	ENLEPEHEYKCDSEI CCCCCCCCCCCCHHH	28.69	-
378	N-linked_Glycosylation	ILYNNHKFTNASKII HHCCCCCCCCHHHHE	45.40	UniProtKB CARBOHYD
380	N-linked_Glycosylation	YNNHKFTNASKIIKT CCCCCCCCHHHHEEC	26.85	-
381	Ubiquitination	NNHKFTNASKIIKTD CCCCCCCHHHHEECC	46.14	-
384	Ubiquitination	KFTNASKIIKTDFGS CCCCHHHHEECCCCC	45.58	-
419	N-linked_Glycosylation	WNPPQRSFHNFTLCY CCCCCCCCCCEEEEE	29.59	19349973
421	N-linked_Glycosylation	PPQRSFHNFTLCYIK CCCCCCCCEEEEEEE	22.64	19349973
430	Acetylation	TLCYIKETEKDCLNL EEEEEECCHHHHHCC	62.25	25953088
437	Acetylation	TEKDCLNLDKNLIKY CHHHHHCCCCCHHHH	57.74	20167786
437	Ubiquitination	TEKDCLNLDKNLIKY CHHHHHCCCCCHHHH	57.74	-
451	Phosphorylation	YDLQNLKPYTKYVLS HHHHHCCCCCHHHHH	25.15	-
453	Phosphorylation	LQNLKPYTKYVLSLH HHHCCCCCHHHHHEE	9.98	-
456	Phosphorylation	LKPYTKYVLSLHAYI CCCCCHHHHHEEHHH	14.20	-
468	N-linked_Glycosylation	AYIIAKVQRNGSAAM HHHHHHHHHCCCEEE	31.51	UniProtKB CARBOHYD
470	N-linked_Glycosylation	IIAKVQRNGSAAMCH HHHHHHHCCCEEEEE	19.19	-
470	Phosphorylation	IIAKVQRNGSAAMCH HHHHHHHCCCEEEEE	19.19	23401153
480	Phosphorylation	AAMCHFTTKSAPPSQ EEEEEEECCCCCHHH	43.87	23401153
484	Phosphorylation	HFTTKSAPPSQVWNM EEECCCCCHHHEEEE	35.99	23401153
488	N-linked_Glycosylation	KSAPPSQVWNMTVSM CCCCHHHEEEEEEEE	19.86	19349973
490	N-linked_Glycosylation	APPSQVWNMTVSMTS CCHHHEEEEEEEECC	13.25	19349973
492	O-linked_Glycosylation	PSQVWNMTVSMTSDN HHHEEEEEEEECCCC	13.74	OGP
494	Phosphorylation	QVWNMTVSMTSDNSM HEEEEEEEECCCCCC	25.98	22210691
495	Phosphorylation	VWNMTVSMTSDNSMH EEEEEEEECCCCCCE	26.59	28787133
497	N-linked_Glycosylation	NMTVSMTSDNSMHVK EEEEEECCCCCCEEE	40.79	19349973
529	N-linked_Glycosylation	VEAGNTLVRNESHKN EECCCEEECCCCCCC	47.87	UniProtKB CARBOHYD
531	N-linked_Glycosylation	AGNTLVRNESHKNCD CCCEEECCCCCCCCC	43.22	-
540	Ubiquitination	SHKNCDFRVKDLQYS CCCCCCCEEEECCCC	48.76	-
544	Phosphorylation	CDFRVKDLQYSTDYT CCCEEEECCCCCCEE	22.34	-
546	Phosphorylation	FRVKDLQYSTDYTFK CEEEECCCCCCEEEE	28.26	-
548	Phosphorylation	VKDLQYSTDYTFKAY EEECCCCCCEEEEEE	17.73	-
559	Phosphorylation	FKAYFHNGDYPGEPF EEEEEECCCCCCCCE	17.97	-
607	Phosphorylation	KIYDLHKKRSCNLDE HHHHHHHHCCCCCHH	19.08	28122231
639	Phosphorylation	PIHADILLETYKRKI CCCHHHHHHHHHHHH	34.02	29978859
640	Phosphorylation	IHADILLETYKRKIA CCHHHHHHHHHHHHH	10.22	27642862
641	Acetylation	HADILLETYKRKIAD CHHHHHHHHHHHHHH	55.42	25953088
641	Ubiquitination	HADILLETYKRKIAD CHHHHHHHHHHHHHH	55.42	-
657	Phosphorylation	GRLFLAEFQSIPRVF CCEEEEEHHCCCCHH	39.62	29978859
663	Phosphorylation	EFQSIPRVFSKFPIK EHHCCCCHHHCCCHH	30.45	28450419
664	Acetylation	FQSIPRVFSKFPIKE HHCCCCHHHCCCHHH	43.63	25953088
664	Ubiquitination	FQSIPRVFSKFPIKE HHCCCCHHHCCCHHH	43.63	2189047
668	Ubiquitination	PRVFSKFPIKEARKP CCHHHCCCHHHHCCC	45.63	-
681	Phosphorylation	KPFNQNKNRYVDILP CCCCCCCCCCEEECC	16.33	28796482
683	Phosphorylation	FNQNKNRYVDILPYD CCCCCCCCEEECCCC	27.98	-
687	Phosphorylation	KNRYVDILPYDYNRV CCCCEEECCCCCCEE	27.84	28796482
689	Phosphorylation	RYVDILPYDYNRVEL CCEEECCCCCCEEEE	10.06	28796482
703	Phosphorylation	LSEINGDAGSNYINA EEECCCCCCCCCCCH	28.34	29978859
705	Phosphorylation	EINGDAGSNYINASY ECCCCCCCCCCCHHH	9.39	29978859
709	Phosphorylation	DAGSNYINASYIDGF CCCCCCCCHHHCCCC	20.38	28796482
710	Phosphorylation	AGSNYINASYIDGFK CCCCCCCHHHCCCCC	10.71	28796482
715	Ubiquitination	INASYIDGFKEPRKY CCHHHCCCCCCCHHH	72.79	-
719	Ubiquitination	YIDGFKEPRKYIAAQ HCCCCCCCHHHHEEC	52.29	-
720	Phosphorylation	IDGFKEPRKYIAAQG CCCCCCCHHHHEECC	9.32	27642862
759	Ubiquitination	TRCEEGNRNKCAEYW EECCCCCCCHHHHHC	31.42	-
763	Phosphorylation	EGNRNKCAEYWPSME CCCCCHHHHHCCCHH	12.23	29978859
766	Phosphorylation	RNKCAEYWPSMEEGT CCHHHHHCCCHHHHC	25.36	29978859
780	Acetylation	TRAFGDVVVKINQHK CEEECCEEEEECCCC	25.08	25953088
780	Ubiquitination	TRAFGDVVVKINQHK CEEECCEEEEECCCC	25.08	-
790	Phosphorylation	INQHKRCPDYIIQKL ECCCCCCCHHHHHHH	5.76	-
800	Acetylation	IIQKLNIVNKKEKAT HHHHHCCCCCCCCCC	51.95	25953088
800	Ubiquitination	IIQKLNIVNKKEKAT HHHHHCCCCCCCCCC	51.95	-
801	Ubiquitination	IQKLNIVNKKEKATG HHHHCCCCCCCCCCC	60.28	-
831	Ubiquitination	VPEDPHLLLKLRRRV CCCCHHHHHHHHHHH	39.66	-
858	Phosphorylation	VHCSAGVGRTGTYIG EECCCCCCCCCCEEE	28.13	-
860	Phosphorylation	CSAGVGRTGTYIGID CCCCCCCCCCEEEHH	16.02	-
861	Phosphorylation	SAGVGRTGTYIGIDA CCCCCCCCCEEEHHH	9.86	-
880	Phosphorylation	LEAENKVDVYGYVVK HHHHCCEEEEEEEEE	9.77	28796482
882	Phosphorylation	AENKVDVYGYVVKLR HHCCEEEEEEEEEEC	5.60	28796482
900	Phosphorylation	CLMVQVEAQYILIHQ EEEEEEEHHHHHHHH	12.54	-
926	Phosphorylation	EVNLSELHPYLHNMK CCCHHHHHHHHHHCC	15.17	-
932	Ubiquitination	LHPYLHNMKKRDPPS HHHHHHHCCCCCCCC	51.79	-
937	Phosphorylation	HNMKKRDPPSEPSPL HHCCCCCCCCCCCCH	68.48	30576142
951	Phosphorylation	LEAEFQRLPSYRSWR HHHHHHCCCCHHHHH	37.46	26074081
952	Phosphorylation	EAEFQRLPSYRSWRT HHHHHCCCCHHHHHH	13.51	26074081
954	Phosphorylation	EFQRLPSYRSWRTQH HHHCCCCHHHHHHCC	16.81	26074081
957	Phosphorylation	RLPSYRSWRTQHIGN CCCCHHHHHHCCCCC	20.45	26074081
967	Ubiquitination	QHIGNQEENKSKNRN CCCCCCCCCCCCCCC	67.11	-
968	Phosphorylation	HIGNQEENKSKNRNS CCCCCCCCCCCCCCC	46.90	29978859
973	Phosphorylation	EENKSKNRNSNVIPY CCCCCCCCCCCCCCC	29.27	29970186
975	Phosphorylation	NKSKNRNSNVIPYDY CCCCCCCCCCCCCCC	4.71	20166139
978	Phosphorylation	KNRNSNVIPYDYNRV CCCCCCCCCCCCCCC	21.67	19690332
980	Phosphorylation	RNSNVIPYDYNRVPL CCCCCCCCCCCCCCC	10.06	28796482
992	Phosphorylation	VPLKHELEMSKESEH CCCCCCHHCCCCCCC	24.72	20164059
994	Phosphorylation	LKHELEMSKESEHDS CCCCHHCCCCCCCCC	54.79	23186163
995	Phosphorylation	KHELEMSKESEHDSD CCCHHCCCCCCCCCC	43.92	26552605
997	Phosphorylation	ELEMSKESEHDSDES CHHCCCCCCCCCCCC	49.51	15302935
999	Phosphorylation	EMSKESEHDSDESSD HCCCCCCCCCCCCCC	45.22	30576142
1001	Phosphorylation	SKESEHDSDESSDDD CCCCCCCCCCCCCCC	56.97	10066810
1002	Phosphorylation	KESEHDSDESSDDDS CCCCCCCCCCCCCCC	44.02	30576142
1003	Phosphorylation	ESEHDSDESSDDDSD CCCCCCCCCCCCCCC	42.91	23911959
1004	Phosphorylation	SEHDSDESSDDDSDS CCCCCCCCCCCCCCC	73.37	10066810
1005	Phosphorylation	EHDSDESSDDDSDSE CCCCCCCCCCCCCCC	60.30	10066810
1007	Phosphorylation	DSDESSDDDSDSEEP CCCCCCCCCCCCCCH	50.45	23401153
1009	Phosphorylation	DESSDDDSDSEEPSK CCCCCCCCCCCCHHH	48.05	26552605
1013	Phosphorylation	DDDSDSEEPSKYINA CCCCCCCCHHHHHCH	41.17	25072903
1019	Phosphorylation	EEPSKYINASFIMSY CCHHHHHCHHHHHHH	15.71	10066810
1058	Sulfoxidation	FQRKVKVIVMLTELK HHHHCEEEEEEEECC	2.35	21406390
1063	Acetylation	KVIVMLTELKHGDQE EEEEEEEECCCCCHH	39.03	21466224
1089	Ubiquitination	TYGDIEVDLKDTDKS EEEEEEEECCCCCCC	54.86	-
1093	Acetylation	IEVDLKDTDKSSTYT EEEECCCCCCCCEEE	48.69	-
1093	Ubiquitination	IEVDLKDTDKSSTYT EEEECCCCCCCCEEE	48.69	-
1097	Phosphorylation	LKDTDKSSTYTLRVF CCCCCCCCEEEEEEE	13.01	24719451
1098	Phosphorylation	KDTDKSSTYTLRVFE CCCCCCCEEEEEEEE	14.26	24719451
1107	Phosphorylation	TLRVFELRHSKRKDS EEEEEEEECCCCCCC	27.93	27135362
1112	Phosphorylation	ELRHSKRKDSRTVYQ EEECCCCCCCCEEEE	32.65	27135362
1114	Phosphorylation	RHSKRKDSRTVYQYQ ECCCCCCCCEEEEEE	27.76	24719451
1116	Phosphorylation	SKRKDSRTVYQYQYT CCCCCCCEEEEEEEC	10.82	24719451
1124	Phosphorylation	VYQYQYTNWSVEQLP EEEEEECCCCHHHCC	20.18	24719451
1143	Ubiquitination	ELISMIQVVKQKLPQ HHHHHHHHHHHHCCC	42.74	-
1216	Phosphorylation	PGMVSTFEQYQFLYD CCCCCHHHHHHHHHH	8.27	7507203
1220	Phosphorylation	STFEQYQFLYDVIAS CHHHHHHHHHHHHHH	14.95	-
1243	Ubiquitination	VKKNNHQEDKIEFDN CCCCCCCCCCEECCH	43.30	-
1268	Ubiquitination	CVNPLGAPEKLPEAK CCCCCCCCCCCHHHH	69.18	-
1279	Phosphorylation	PEAKEQAEGSEPTSG HHHHHHHCCCCCCCC	31.72	30108239
1281	Phosphorylation	AKEQAEGSEPTSGTE HHHHHCCCCCCCCCC	33.30	27251275
1282	Phosphorylation	KEQAEGSEPTSGTEG HHHHCCCCCCCCCCC	35.42	29970186
1283	Phosphorylation	EQAEGSEPTSGTEGP HHHCCCCCCCCCCCC	55.20	30576142
1285	Phosphorylation	AEGSEPTSGTEGPEH HCCCCCCCCCCCCCC	37.22	30576142
1291	Phosphorylation	TSGTEGPEHSVNGPA CCCCCCCCCCCCCCC	18.67	30108239
1297	Phosphorylation	PEHSVNGPASPALNQ CCCCCCCCCCCCCCC	17.53	23401153
1299	Phosphorylation	HSVNGPASPALNQGS CCCCCCCCCCCCCCC	19.36	19690332
1304	Phosphorylation	PASPALNQGS----- CCCCCCCCCC-----	27.56	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
999	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
999	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
999	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
1002	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1002	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
1002	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
1003	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1003	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
1003	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
1007	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1007	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
1007	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
1216	Y	Phosphorylation	Kinase	CSK	P41240	PSP
1216	Y	Phosphorylation	Kinase	LCK	P06239	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PTPRC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PTPRC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAEP_HUMAN	PAEP	physical	12556471
GANAB_HUMAN	GANAB	physical	9148925
GLU2B_HUMAN	PRKCSH	physical	9148925
LCK_HUMAN	LCK	physical	8473339
PTCA_HUMAN	PTPRCAP	physical	8537410
PLK3_HUMAN	PLK3	physical	11551930
LCK_HUMAN	LCK	physical	8576115
CD8A_HUMAN	CD8A	physical	1834739
CD4_HUMAN	CD4	physical	1834739
GANAB_HUMAN	GANAB	physical	10921916
CD3Z_HUMAN	CD247	physical	7526385
GANAB_HUMAN	GANAB	physical	11564800
LYN_HUMAN	LYN	physical	7516335
CD79A_HUMAN	CD79A	physical	7516335
CD79B_HUMAN	CD79B	physical	7516335
SKAP1_HUMAN	SKAP1	physical	11909961

Drug and Disease Associations

Kegg Disease
OMIM Disease
608971	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID)
126200	Multiple sclerosis (MS)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PTPRC_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232; ASN-240; ASN-276;ASN-284; ASN-335; ASN-419; ASN-488 AND ASN-497, AND MASS SPECTROMETRY.	19349973 [Abstract]
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232 AND ASN-335, AND MASSSPECTROMETRY.	19159218 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973 AND SER-1297, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973, AND MASSSPECTROMETRY.	19367720 [Abstract]
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