dbPTM

PTCA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PTCA_HUMAN
UniProt AC	Q14761
Protein Name	Protein tyrosine phosphatase receptor type C-associated protein
Gene Name	PTPRCAP
Organism	Homo sapiens (Human).
Sequence Length	206
Subcellular Localization	Membrane Single-pass membrane protein .
Protein Description
Protein Sequence	MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	WRRLSRDSGGYYHPA HHHHCCCCCCCCCHH	32.76	28796482
64	Phosphorylation	LSRDSGGYYHPARLG HCCCCCCCCCHHHHH	11.35	28796482
65	Phosphorylation	SRDSGGYYHPARLGA CCCCCCCCCHHHHHH	12.47	28796482
85	Phosphorylation	TRRLLWASPPGRWLQ CCHHHHCCCCCCHHH	21.75	-
99	Phosphorylation	QARAELGSTDNDLER HHHHHHCCCHHHHHH	45.25	23401153
100	Phosphorylation	ARAELGSTDNDLERQ HHHHHCCCHHHHHHH	36.70	25072903
113	Phosphorylation	RQEDEQDTDYDHVAD HHHHHCCCCCCHHHC	35.83	26657352
115	Phosphorylation	EDEQDTDYDHVADGG HHHCCCCCCHHHCCC	15.27	28796482
138	Phosphorylation	EQQCGEASSPEQVPV CCCCCCCCCCCCCCC	41.97	26074081
139	Phosphorylation	QQCGEASSPEQVPVR CCCCCCCCCCCCCCC	39.23	26074081
153	Phosphorylation	RAEEARDSDTEGDLV CHHHHCCCCCCCCEE	40.66	26657352
155	Phosphorylation	EEARDSDTEGDLVLG HHHCCCCCCCCEEEC	45.91	26657352
163	Phosphorylation	EGDLVLGSPGPASAG CCCEEECCCCCCCCC	23.63	26552605
168	Phosphorylation	LGSPGPASAGGSAEA ECCCCCCCCCCCHHH	30.49	26074081
172	Phosphorylation	GPASAGGSAEALLSD CCCCCCCCHHHHHHH	23.24	26552605
178	Phosphorylation	GSAEALLSDLHAFAG CCHHHHHHHHHHHCC	38.69	26552605
186	Phosphorylation	DLHAFAGSAAWDDSA HHHHHCCCCCCCHHH	16.04	24667141

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
153	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
163	S	Phosphorylation	Kinase	ERK2	P28482	PSP
163	S	Phosphorylation	Kinase	ERK1	P27361	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PTCA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PTCA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
EF1A1_HUMAN	EEF1A1	physical	16169070

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PTCA_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASSSPECTROMETRY.	19690332 [Abstract]