CD79A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD79A_HUMAN
• UniProt AC: P11912
• Protein Name: B-cell antigen receptor complex-associated protein alpha chain
• Gene Name: CD79A
• Organism: Homo sapiens (Human).
• Sequence Length: 226
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur ou
• Protein Description: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells..
• Protein Sequence: MPGGPGVLQALPATIFLLFLLSAVYLGPGCQALWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLGPGEDPNGTLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKLGLDAGDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	AHFQCPHNSSNNANV CCCCCCCCCCCCCCE	32.07	UniProtKB CARBOHYD
63	N-linked_Glycosylation	HNSSNNANVTWWRVL CCCCCCCCEEEEEEE	33.60	UniProtKB CARBOHYD
73	N-linked_Glycosylation	WWRVLHGNYTWPPEF EEEEEECCCCCCHHH	21.95	UniProtKB CARBOHYD
88	N-linked_Glycosylation	LGPGEDPNGTLIIQN CCCCCCCCCCEEEEE	69.29	UniProtKB CARBOHYD
97	N-linked_Glycosylation	TLIIQNVNKSHGGIY CEEEEECCCCCCCEE	47.89	UniProtKB CARBOHYD
112	N-linked_Glycosylation	VCRVQEGNESYQQSC EEEEEECCCEEHHHC	34.00	UniProtKB CARBOHYD
140	Phosphorylation	FLDMGEGTKNRIITA CCCCCCCCCCEEEEE	22.35	-
141	Ubiquitination	LDMGEGTKNRIITAE CCCCCCCCCEEEEEH	55.90	25015289
161	Phosphorylation	FCAVVPGTLLLFRKR HHHHCCCHHHHHHHH	14.25	9531288
173	Ubiquitination	RKRWQNEKLGLDAGD HHHHHCCCCCCCCCC	56.24	-
182	Phosphorylation	GLDAGDEYEDENLYE CCCCCCCCCCCCCCC	33.16	22817900
187	Ubiquitination	DEYEDENLYEGLNLD CCCCCCCCCCCCCHH	3.76	29967540
188	Phosphorylation	EYEDENLYEGLNLDD CCCCCCCCCCCCHHH	21.38	22817900
197	Phosphorylation	GLNLDDCSMYEDISR CCCHHHCCHHHHHHH	31.24	25954137
199	Phosphorylation	NLDDCSMYEDISRGL CHHHCCHHHHHHHHC	8.31	22817900
204	Asymmetric dimethylarginine	SMYEDISRGLQGTYQ CHHHHHHHHCCCCCC	50.61	-
204	Methylation	SMYEDISRGLQGTYQ CHHHHHHHHCCCCCC	50.61	-
209	Phosphorylation	ISRGLQGTYQDVGSL HHHHCCCCCCCCCCC	12.68	28796482
210	Phosphorylation	SRGLQGTYQDVGSLN HHHCCCCCCCCCCCE	15.00	28796482
215	Phosphorylation	GTYQDVGSLNIGDVQ CCCCCCCCCEECCEE	20.35	26657352
225	Ubiquitination	IGDVQLEKP------ ECCEEECCC------	65.70	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
188	Y	Phosphorylation	Kinase	LYN	P07948	PhosphoELM
188	Y	Phosphorylation	Kinase	SRC-TYPE TYR-KINASES	-	Uniprot
199	Y	Phosphorylation	Kinase	FYN	P06241	PhosphoELM
199	Y	Phosphorylation	Kinase	SRC-TYPE TYR-KINASES	-	Uniprot
210	Y	Phosphorylation	Kinase	TYR-KINASES	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD79A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD79A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD79B_HUMAN	CD79B	physical	12886015
KSYK_HUMAN	SYK	physical	7500027
AMBP_HUMAN	AMBP	physical	6196366
BLNK_HUMAN	BLNK	physical	11909947
CD79B_HUMAN	CD79B	physical	9531288
FATE1_HUMAN	FATE1	physical	25416956
ATP23_HUMAN	XRCC6BP1	physical	28514442
NDKM_HUMAN	NME4	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
NTCP7_HUMAN	SLC10A7	physical	28514442
MTG2_HUMAN	MTG2	physical	28514442
CDYL_HUMAN	CDYL	physical	28514442
MET15_HUMAN	METTL15	physical	28514442
SYHM_HUMAN	HARS2	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
MICU1_HUMAN	MICU1	physical	28514442
NSUN3_HUMAN	NSUN3	physical	28514442
GTPB6_HUMAN	GTPBP6	physical	28514442
PEX16_HUMAN	PEX16	physical	28514442
PEX6_HUMAN	PEX6	physical	28514442
KMCP1_HUMAN	SLC25A30	physical	28514442
ABD18_HUMAN	C4orf29	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
GTR8_HUMAN	SLC2A8	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
DEGS1_HUMAN	DEGS1	physical	28514442
S26A6_HUMAN	SLC26A6	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
DD19B_HUMAN	DDX19B	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
PAPD1_HUMAN	MTPAP	physical	28514442
SPG7_HUMAN	SPG7	physical	28514442
BCAM_HUMAN	BCAM	physical	28514442
PTPM1_HUMAN	PTPMT1	physical	28514442
UBP30_HUMAN	USP30	physical	28514442
BDH_HUMAN	BDH1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00001: Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
• H00085: Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's aga
• OMIM Disease
• 613501: Agammaglobulinemia 3, autosomal recessive (AGM3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.