MTG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTG2_HUMAN
• UniProt AC: Q9H4K7
• Protein Name: Mitochondrial ribosome-associated GTPase 2
• Gene Name: MTG2
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process..
• Protein Sequence: MAPARCFSARLRTVFQGVGHWALSTWAGLKPSRLLPQRASPRLLSVGRADLAKHQELPGKKLLSEKKLKRYFVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLSSVLSRYQGFSGEDGGSKNCFGRSGAVLYIRVPVGTLVKEGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVAHAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGHLQIAVADIPGIIRGAHQNRGLGSAFLRHIERCRFLLFVVDLSQPEPWTQVDDLKYELEMYEKGLSARPHAIVANKIDLPEAQANLSQLRDHLGQEVIVLSALTGENLEQLLLHLKVLYDAYAEAELGQGRQPLRW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	RLLPQRASPRLLSVG HCCCCCCCCCCEEEC		32645325
64	Phosphorylation	LPGKKLLSEKKLKRY CCCCCCCCHHHHHHH		24719451
71	Phosphorylation	SEKKLKRYFVDYRRV CHHHHHHHCCCCCEE		26074081
75	Phosphorylation	LKRYFVDYRRVLVCG HHHHCCCCCEEEEEC		26074081
123	Ubiquitination	LRVDQQVKSLSSVLS EEEHHHHHHHHHHHH		21890473
123	Ubiquitination	LRVDQQVKSLSSVLS EEEHHHHHHHHHHHH		21890473
124	Phosphorylation	RVDQQVKSLSSVLSR EEHHHHHHHHHHHHH		17322306
130	Phosphorylation	KSLSSVLSRYQGFSG HHHHHHHHHHCCCCC		17322306
132	Phosphorylation	LSSVLSRYQGFSGED HHHHHHHHCCCCCCC		23312004
136	Phosphorylation	LSRYQGFSGEDGGSK HHHHCCCCCCCCCCC		23312004
139	Ubiquitination	YQGFSGEDGGSKNCF HCCCCCCCCCCCCCC		21890473
142	Phosphorylation	FSGEDGGSKNCFGRS CCCCCCCCCCCCCCC		23312004
151	Ubiquitination	NCFGRSGAVLYIRVP CCCCCCCCEEEEEEE		21890473
239	Phosphorylation	FPNAGKSSLLRAISN CCCCCHHHHHHHHHC		24719451
357	Phosphorylation	PEAQANLSQLRDHLG HHHHHHHHHHHHHHC		-
389	Phosphorylation	LLHLKVLYDAYAEAE HHHHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPCE_HUMAN	PREP	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
MPPA_HUMAN	PMPCA	physical	28514442
SIR3_HUMAN	SIRT3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.