CDYL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDYL_HUMAN
• UniProt AC: Q9Y232
• Protein Name: Chromodomain Y-like protein {ECO:0000303|PubMed:10192397}
• Gene Name: CDYL {ECO:0000303|PubMed:10192397, ECO:0000312|HGNC:HGNC:1811}
• Organism: Homo sapiens (Human).
• Sequence Length: 598
• Subcellular Localization: Isoform 2: Nucleus . Chromosome . Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is requi
• Protein Description: Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). [PubMed: 19808672]
• Protein Sequence: MTFQASHRSAWGKSRKKNWQYEGPTQKLFLKRNNVSAPDGPSDPSISVSSEQSGAQQPPALQVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKESTLTRTNRTSPNNARKQISRSTNSNFSKTSPKALVIGKDHESKNSQLFAASQKFRKNTAPSLSSRKNMDLAKSGIKILVPKSPVKSRTAVDGFQSESPEKLDPVEQGQEDTVAPEVAAEKPVGALLGPGAERARMGSRPRIHPLVPQVPGPVTAAMATGLAVNGKGTSPFMDALTANGTTNIQTSVTGVTASKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMREVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMAEAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MTFQASHRSA -----CCCCCCCHHH		19691289
3 (in isoform 2)	Phosphorylation	-		19691289
7 (in isoform 2)	Phosphorylation	-		20068231
15 (in isoform 4)	Phosphorylation	-		27107777
20	Ubiquitination	KSRKKNWQYEGPTQK CCCCCCCCCCCCCCC		24816145
21	Phosphorylation	SRKKNWQYEGPTQKL CCCCCCCCCCCCCCE		29978859
25	Phosphorylation	NWQYEGPTQKLFLKR CCCCCCCCCCEEEEE		29978859
32	Phosphorylation	TQKLFLKRNNVSAPD CCCEEEEECCCCCCC		17081983
34	Phosphorylation	KLFLKRNNVSAPDGP CEEEEECCCCCCCCC		16565220
37	Ubiquitination	LKRNNVSAPDGPSDP EEECCCCCCCCCCCC		32015554
38	Phosphorylation	KRNNVSAPDGPSDPS EECCCCCCCCCCCCC		19413330
53	Ubiquitination	ISVSSEQSGAQQPPA CCCCCCCCCCCCCCC		29967540
74	Phosphorylation	VDKRKNKKGKTEYLV HCCCCCCCCCCEEEE		19651622
75	Phosphorylation	DKRKNKKGKTEYLVR CCCCCCCCCCEEEEE		19651622
86	Phosphorylation	YLVRWKGYDSEDDTW EEEEECCCCCCCCCC		21955146
88	Phosphorylation	VRWKGYDSEDDTWEP EEECCCCCCCCCCCH		23401153
92	Phosphorylation	GYDSEDDTWEPEQHL CCCCCCCCCCHHHHC		30266825
93	Ubiquitination	YDSEDDTWEPEQHLV CCCCCCCCCHHHHCC		29967540
97	Ubiquitination	DDTWEPEQHLVNCEE CCCCCHHHHCCCHHH		29967540
103	Ubiquitination	EQHLVNCEEYIHDFN HHHCCCHHHHHHHHH		29967540
105	Phosphorylation	HLVNCEEYIHDFNRR HCCCHHHHHHHHHHH		23090842
108	Ubiquitination	NCEEYIHDFNRRHTE CHHHHHHHHHHHHCH		32015554
118	Ubiquitination	RRHTEKQKESTLTRT HHHCHHHHHHHCCCC		21890473
118	Ubiquitination	RRHTEKQKESTLTRT HHHCHHHHHHHCCCC		21890473
118 (in isoform 2)	Ubiquitination	-		21890473
121	Ubiquitination	TEKQKESTLTRTNRT CHHHHHHHCCCCCCC		29967540
125	Phosphorylation	KESTLTRTNRTSPNN HHHHCCCCCCCCCCH		30242111
128	Phosphorylation	TLTRTNRTSPNNARK HCCCCCCCCCCHHHH		25849741
128	Ubiquitination	TLTRTNRTSPNNARK HCCCCCCCCCCHHHH		29967540
129	Phosphorylation	LTRTNRTSPNNARKQ CCCCCCCCCCHHHHH		25849741
133	Ubiquitination	NRTSPNNARKQISRS CCCCCCHHHHHHHHH		33845483
135	"N6,N6,N6-trimethyllysine"	TSPNNARKQISRSTN CCCCHHHHHHHHHCC		-
135	Methylation	TSPNNARKQISRSTN CCCCHHHHHHHHHCC		18438403
140	Phosphorylation	ARKQISRSTNSNFSK HHHHHHHHCCCCCCC		24732914
140	Ubiquitination	ARKQISRSTNSNFSK HHHHHHHHCCCCCCC		32015554
141	Phosphorylation	RKQISRSTNSNFSKT HHHHHHHCCCCCCCC		27174698
143	Phosphorylation	QISRSTNSNFSKTSP HHHHHCCCCCCCCCC		24732914
146	Phosphorylation	RSTNSNFSKTSPKAL HHCCCCCCCCCCCEE		24732914
147	Acetylation	STNSNFSKTSPKALV HCCCCCCCCCCCEEE		26051181
147	Phosphorylation	STNSNFSKTSPKALV HCCCCCCCCCCCEEE		20068231
148	Phosphorylation	TNSNFSKTSPKALVI CCCCCCCCCCCEEEE		24732914
149	Phosphorylation	NSNFSKTSPKALVIG CCCCCCCCCCEEEEC		22617229
153	Phosphorylation	SKTSPKALVIGKDHE CCCCCCEEEECCCCC		19664995
157	Trimethylation	PKALVIGKDHESKNS CCEEEECCCCCCHHH		-
157	Methylation	PKALVIGKDHESKNS CCEEEECCCCCCHHH		23644510
160	Phosphorylation	LVIGKDHESKNSQLF EEECCCCCCHHHHHH		18452278
161	Phosphorylation	VIGKDHESKNSQLFA EECCCCCCHHHHHHH		26714015
162	Phosphorylation	IGKDHESKNSQLFAA ECCCCCCHHHHHHHH		19664994
162	Ubiquitination	IGKDHESKNSQLFAA ECCCCCCHHHHHHHH		32015554
164	Phosphorylation	KDHESKNSQLFAASQ CCCCCHHHHHHHHHH		26714015
170	Phosphorylation	NSQLFAASQKFRKNT HHHHHHHHHHHHHCC		25159151
172	Ubiquitination	QLFAASQKFRKNTAP HHHHHHHHHHHCCCC		21890473
172	Ubiquitination	QLFAASQKFRKNTAP HHHHHHHHHHHCCCC		21890473
172 (in isoform 1)	Ubiquitination	-		21890473
174	Ubiquitination	FAASQKFRKNTAPSL HHHHHHHHHCCCCCH		21963094
180	Phosphorylation	FRKNTAPSLSSRKNM HHHCCCCCHHHHCCH		25159151
182	Phosphorylation	KNTAPSLSSRKNMDL HCCCCCHHHHCCHHH		25159151
185	Ubiquitination	APSLSSRKNMDLAKS CCCHHHHCCHHHHHC		29967540
201	Phosphorylation	IKILVPKSPVKSRTA CEEEEECCCCCCCCC		22167270
205	Phosphorylation	VPKSPVKSRTAVDGF EECCCCCCCCCCCCC		24732914
207	Phosphorylation	KSPVKSRTAVDGFQS CCCCCCCCCCCCCCC		30278072
214	Phosphorylation	TAVDGFQSESPEKLD CCCCCCCCCCCCCCC		23401153
216	Phosphorylation	VDGFQSESPEKLDPV CCCCCCCCCCCCCCC		19664994
230	Phosphorylation	VEQGQEDTVAPEVAA CCCCCCCCCCHHHHC		23927012
236	Ubiquitination	DTVAPEVAAEKPVGA CCCCHHHHCCCCCCC		32015554
249	Ubiquitination	GALLGPGAERARMGS CCCCCCCHHHHCCCC		29901268
249 (in isoform 3)	Ubiquitination	-		21890473
250	Ubiquitination	ALLGPGAERARMGSR CCCCCCHHHHCCCCC		32015554
256	Phosphorylation	AERARMGSRPRIHPL HHHHCCCCCCCCCCC		-
260	Ubiquitination	RMGSRPRIHPLVPQV CCCCCCCCCCCCCCC		29967540
271	Ubiquitination	VPQVPGPVTAAMATG CCCCCCCCHHHHHHC		32015554
272	Ubiquitination	PQVPGPVTAAMATGL CCCCCCCHHHHHHCC		32015554
284	Ubiquitination	TGLAVNGKGTSPFMD HCCEECCCCCCCCHH		21963094
287 (in isoform 3)	Ubiquitination	-		21890473
300	Ubiquitination	LTANGTTNIQTSVTG HHCCCCCCCEEECCE		32015554
300 (in isoform 3)	Ubiquitination	-		21890473
305	Phosphorylation	TTNIQTSVTGVTASK CCCCEEECCEEECCC		20068231
306	Ubiquitination	TNIQTSVTGVTASKR CCCEEECCEEECCCC		21963094
312	Acetylation	VTGVTASKRKFIDDR CCEEECCCCCCCCCC		26051181
314	Methylation	GVTASKRKFIDDRRD EEECCCCCCCCCCCC		-
322	Ubiquitination	FIDDRRDQPFDKRLR CCCCCCCCCCCHHHC		29967540
326	Ubiquitination	RRDQPFDKRLRFSVR CCCCCCCHHHCCEEE		32015554
331	Phosphorylation	FDKRLRFSVRQTESA CCHHHCCEEECCCCH		21712546
346	Ubiquitination	YRYRDIVVRKQDGFT HHCCEEEEEECCCCE		33845483
352	Ubiquitination	VVRKQDGFTHILLST EEEECCCCEEEEEEC		21963094
353	Phosphorylation	VRKQDGFTHILLSTK EEECCCCEEEEEECC		20068231
358	Phosphorylation	GFTHILLSTKSSENN CCEEEEEECCCCCCC		20068231
359	Phosphorylation	FTHILLSTKSSENNS CEEEEEECCCCCCCC		20068231
360	Ubiquitination	THILLSTKSSENNSL EEEEEECCCCCCCCC		-
361	Phosphorylation	HILLSTKSSENNSLN EEEEECCCCCCCCCC		20068231
362	Phosphorylation	ILLSTKSSENNSLNP EEEECCCCCCCCCCH		20068231
366	Phosphorylation	TKSSENNSLNPEVMR CCCCCCCCCCHHHHH		20068231
366	Ubiquitination	TKSSENNSLNPEVMR CCCCCCCCCCHHHHH		29967540
368	Ubiquitination	SSENNSLNPEVMREV CCCCCCCCHHHHHHH		32015554
374	Ubiquitination	LNPEVMREVQSALST CCHHHHHHHHHHHHH		21963094
377	Phosphorylation	EVMREVQSALSTAAA HHHHHHHHHHHHHCC		20068231
380	Phosphorylation	REVQSALSTAAADDS HHHHHHHHHHCCCCC		28787133
381	Phosphorylation	EVQSALSTAAADDSK HHHHHHHHHCCCCCH		20860994
387	Phosphorylation	STAAADDSKLVLLSA HHHCCCCCHHHHHHH		20860994
390	Ubiquitination	AADDSKLVLLSAVGS CCCCCHHHHHHHHHH		21890473
403	Ubiquitination	GSVFCCGLDFIYFIR HHHHHCCHHHHHHHH		21890473
422	Ubiquitination	DRKRESTKMAEAIRN HHHHHHHHHHHHHHH		33845483
454	Ubiquitination	GPAIGLGASILPLCD CCCCCCCCHHHHHCC		29967540
462	Ubiquitination	SILPLCDVVWANEKA HHHHHCCEEECCCCE		21963094
484	Ubiquitination	TFGQSPDGCSTVMFP CCCCCCCCCCEEECC		21890473
484	Ubiquitination	TFGQSPDGCSTVMFP CCCCCCCCCCEEECC		21963094
484 (in isoform 2)	Ubiquitination	-		21890473
498	Ubiquitination	PKIMGGASANEMLLS CEECCCCCHHHHHHH		29967540
500	Ubiquitination	IMGGASANEMLLSGR ECCCCCHHHHHHHCC		21890473
506	Ubiquitination	ANEMLLSGRKLTAQE HHHHHHHCCCCCHHH		21963094
513	Ubiquitination	GRKLTAQEACGKGLV CCCCCHHHHCCCCCH		21890473
522	Ubiquitination	CGKGLVSQVFWPGTF CCCCCHHEEECCCCC		21890473
522	Ubiquitination	CGKGLVSQVFWPGTF CCCCCHHEEECCCCC		21890473
522 (in isoform 2)	Ubiquitination	-		21890473
532	Phosphorylation	WPGTFTQEVMVRIKE CCCCCCHHHHHHHHH		20068231
535	Ubiquitination	TFTQEVMVRIKELAS CCCHHHHHHHHHHHC		21890473
535	Ubiquitination	TFTQEVMVRIKELAS CCCHHHHHHHHHHHC		21890473
535 (in isoform 2)	Ubiquitination	-		21890473
538	Ubiquitination	QEVMVRIKELASCNP HHHHHHHHHHHCCCC		21890473
538	Acetylation	QEVMVRIKELASCNP HHHHHHHHHHHCCCC		26051181
538	Ubiquitination	QEVMVRIKELASCNP HHHHHHHHHHHCCCC		22053931
538 (in isoform 1)	Ubiquitination	-		21890473
560	Ubiquitination	ALVRCNMKMELEQAN HHHHCCCHHHHHHHH		32015554
575	Acetylation	ERECEVLKKIWGSAQ HHHHHHHHHHHHHHC		26051181
576	Ubiquitination	RECEVLKKIWGSAQG HHHHHHHHHHHHHCC		21890473
576	Ubiquitination	RECEVLKKIWGSAQG HHHHHHHHHHHHHCC		21890473
576 (in isoform 1)	Ubiquitination	-		21890473
580	Phosphorylation	VLKKIWGSAQGMDSM HHHHHHHHHCCHHHH		20068231
586	Phosphorylation	GSAQGMDSMLKYLQR HHHCCHHHHHHHHHH		20068231
589	Ubiquitination	QGMDSMLKYLQRKID CCHHHHHHHHHHHHH		21890473
589	Ubiquitination	QGMDSMLKYLQRKID CCHHHHHHHHHHHHH		32015554
589 (in isoform 1)	Ubiquitination	-		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDYL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDYL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDYL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	12947414
HDAC2_HUMAN	HDAC2	physical	12947414
SMCA4_HUMAN	SMARCA4	physical	19061646
REST_HUMAN	REST	physical	19061646
SETB1_HUMAN	SETDB1	physical	19061646
ZN644_HUMAN	ZNF644	physical	19061646
HDAC1_HUMAN	HDAC1	physical	19061646
HDAC2_HUMAN	HDAC2	physical	19061646
SNF5_HUMAN	SMARCB1	physical	19061646
EHMT2_HUMAN	EHMT2	physical	19061646
WIZ_HUMAN	WIZ	physical	17967884
EZH2_HUMAN	EZH2	physical	22009739
SUZ12_HUMAN	SUZ12	physical	22009739
MIER1_HUMAN	MIER1	physical	21258344
MIER2_HUMAN	MIER2	physical	21258344
HDAC2_HUMAN	HDAC2	physical	21258344
RBBP4_HUMAN	RBBP4	physical	21258344
MIER2_HUMAN	MIER2	physical	28514442
MIER1_HUMAN	MIER1	physical	28514442
HDAC1_HUMAN	HDAC1	physical	28514442
LAMP2_HUMAN	LAMP2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.