MIER2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIER2_HUMAN
• UniProt AC: Q8N344
• Protein Name: Mesoderm induction early response protein 2
• Gene Name: MIER2
• Organism: Homo sapiens (Human).
• Sequence Length: 545
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor..
• Protein Sequence: MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSASSDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKIYENEDQLLWDPSVLPEREVEEFLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKYVPSGTTDADQDLDGSDPDGPGRPRPEQDTLTGMRTDPLSVDGTAGGLDEPGVASDGLPSSEPGPCSFQQLDESPAVPLSHRPPALADPASYQPAVTAPEPDASPRLAVDFALPKELPLISSHVDLSGDPEETVAPAQVALSVTEFGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHCNVMTC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAEASSLGRQSP ---CCCHHHCCCCCH	20.01	20068231
6	Phosphorylation	--MAEASSLGRQSPR --CCCHHHCCCCCHH	41.72	20068231
11	Phosphorylation	ASSLGRQSPRVVSCL HHHCCCCCHHHHHHH	17.20	28355574
107	Phosphorylation	DPISDRESEGGDVAP CCCCCCCCCCCCCCC	42.30	27499020
132	Phosphorylation	QIAKDLLSGEEEEET HHHHHHHCCCHHHHH	52.00	29507054
139	Phosphorylation	SGEEEEETQSSADDL CCCHHHHHHHCHHHC	36.71	30576142
141	Phosphorylation	EEEEETQSSADDLTP CHHHHHHHCHHHCCC	34.61	30576142
142	Phosphorylation	EEEETQSSADDLTPS HHHHHHHCHHHCCCC	26.37	28634120
147	Phosphorylation	QSSADDLTPSVTSHE HHCHHHCCCCCCCHH	22.10	24144214
149	Phosphorylation	SADDLTPSVTSHEAS CHHHCCCCCCCHHHH	32.56	24144214
151	Phosphorylation	DDLTPSVTSHEASDL HHCCCCCCCHHHHHC	28.80	24144214
152	Phosphorylation	DLTPSVTSHEASDLF HCCCCCCCHHHHHCC	19.71	24144214
156	Phosphorylation	SVTSHEASDLFPNRS CCCCHHHHHCCCCCC	31.68	24144214
163	Phosphorylation	SDLFPNRSGSRFLAD HHCCCCCCCCCCEEC	48.00	26699800
165	Phosphorylation	LFPNRSGSRFLADED CCCCCCCCCCEECCC	22.55	26699800
177	Phosphorylation	DEDREPGSSASSDTE CCCCCCCCCCCCCCC	33.18	30576142
178	Phosphorylation	EDREPGSSASSDTEE CCCCCCCCCCCCCCC	37.78	28450419
180	Phosphorylation	REPGSSASSDTEEDS CCCCCCCCCCCCCCC	30.60	25159151
181	Phosphorylation	EPGSSASSDTEEDSL CCCCCCCCCCCCCCC	48.55	25159151
183	Phosphorylation	GSSASSDTEEDSLPA CCCCCCCCCCCCCCH	43.13	30576142
187	Phosphorylation	SSDTEEDSLPANKCK CCCCCCCCCCHHHCC	39.26	28450419
220	Phosphorylation	NRHCEKIYENEDQLL HHHHHHHHCCCCCCC	24.62	27642862
272	Phosphorylation	KDSEQALYELVKCNF CCHHHHHHHHHHCCC	15.38	25147952
352	Phosphorylation	KKSERYDYFAQQTRL ECCHHHCHHHHHCCC	7.59	-
364	Phosphorylation	TRLGRRKYVPSGTTD CCCCCCCCCCCCCCC	18.78	22210691
369	Phosphorylation	RKYVPSGTTDADQDL CCCCCCCCCCCCCCC	26.32	22210691
379	Phosphorylation	ADQDLDGSDPDGPGR CCCCCCCCCCCCCCC	45.71	28348404
467	Phosphorylation	TAPEPDASPRLAVDF CCCCCCCCCCEEHHH	20.24	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIER2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIER2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIER2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	26186194
HDAC2_HUMAN	HDAC2	physical	26186194
ACD11_HUMAN	ACAD11	physical	26186194
SIN3A_HUMAN	SIN3A	physical	26186194
UBP11_HUMAN	USP11	physical	26186194
EHMT1_HUMAN	EHMT1	physical	26186194
PLK1_HUMAN	PLK1	physical	26186194
EHMT2_HUMAN	EHMT2	physical	26186194
PHLB3_HUMAN	PHLDB3	physical	26186194
LMBL2_HUMAN	L3MBTL2	physical	26186194
PEX14_HUMAN	PEX14	physical	26186194
BRCA2_HUMAN	BRCA2	physical	26186194
PLD1_HUMAN	PLD1	physical	26186194
MGAP_HUMAN	MGA	physical	26186194
CDYL_HUMAN	CDYL	physical	26186194
WIZ_HUMAN	WIZ	physical	26186194
TFDP1_HUMAN	TFDP1	physical	26186194
RING2_HUMAN	RNF2	physical	26186194
ZN644_HUMAN	ZNF644	physical	26186194
ZN318_HUMAN	ZNF318	physical	26186194
AGAP1_HUMAN	AGAP1	physical	26186194
AGAP3_HUMAN	AGAP3	physical	26186194
E2F6_HUMAN	E2F6	physical	26186194
PCGF6_HUMAN	PCGF6	physical	26186194
TYK2_HUMAN	TYK2	physical	26186194
JPH1_HUMAN	JPH1	physical	26186194
LMBL2_HUMAN	L3MBTL2	physical	28514442
E2F6_HUMAN	E2F6	physical	28514442
EHMT2_HUMAN	EHMT2	physical	28514442
TFDP1_HUMAN	TFDP1	physical	28514442
MGAP_HUMAN	MGA	physical	28514442
EHMT1_HUMAN	EHMT1	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442
SIN3A_HUMAN	SIN3A	physical	28514442
AGAP1_HUMAN	AGAP1	physical	28514442
WIZ_HUMAN	WIZ	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
AGAP3_HUMAN	AGAP3	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
PCGF6_HUMAN	PCGF6	physical	28514442
PLD1_HUMAN	PLD1	physical	28514442
PEX14_HUMAN	PEX14	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
UBP11_HUMAN	USP11	physical	28514442
PHLB3_HUMAN	PHLDB3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.