DEGS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEGS1_HUMAN
• UniProt AC: O15121
• Protein Name: Sphingolipid delta(4)-desaturase DES1
• Gene Name: DEGS1
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Mitochondrion . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Membrane ; Lipid-anchor .
• Protein Description: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine)..
• Protein Sequence: MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGSRVSRED ------CCCCCCHHH	24.94	-
2	Myristoylation	------MGSRVSRED ------CCCCCCHHH	24.94	19647031
14	Phosphorylation	REDFEWVYTDQPHAD HHHCCEEECCCCCHH	12.98	28796482
15	Phosphorylation	EDFEWVYTDQPHADR HHCCEEECCCCCHHH	20.66	24719451
29	Ubiquitination	RRREILAKYPEIKSL HHHHHHHHCHHHHHH	58.87	21890473
123	Phosphorylation	IGIPYSISFKRYHMD CCCCEEEEEEEEECC	20.83	24719451
271	Ubiquitination	DFPNIPGKSLPLVRK CCCCCCCCCHHHHHH	43.39	-
278	Ubiquitination	KSLPLVRKIAAEYYD CCHHHHHHHHHHHHH	29.26	21890473
284	Phosphorylation	RKIAAEYYDNLPHYN HHHHHHHHHCCCCCC	7.00	30576142
292	Phosphorylation	DNLPHYNSWIKVLYD HCCCCCCHHHHHHHH	24.02	30576142
307	Phosphorylation	FVMDDTISPYSRMKR HHHCCCCCHHHHHHH	21.63	19647031
309	Phosphorylation	MDDTISPYSRMKRHQ HCCCCCHHHHHHHHH	11.34	27642862
317	Ubiquitination	SRMKRHQKGEMVLE- HHHHHHHCCCCCCC-	51.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEGS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEGS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEGS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PYGM_HUMAN	PYGM	physical	17353931
SURF4_HUMAN	SURF4	physical	17353931
MOT1_HUMAN	SLC16A1	physical	17353931
EIPR1_HUMAN	TSSC1	physical	17353931
NAGPA_HUMAN	NAGPA	physical	21988832
LSG1_HUMAN	LSG1	physical	26186194
IF2P_HUMAN	EIF5B	physical	26186194
UFD1_HUMAN	UFD1L	physical	26186194
HDGR2_HUMAN	HDGFRP2	physical	26186194
SPT6H_HUMAN	SUPT6H	physical	26186194
CYHR1_HUMAN	CYHR1	physical	26186194
T2FA_HUMAN	GTF2F1	physical	26186194
IF2P_HUMAN	EIF5B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"N-Myristoylation targets dihydroceramide Delta4-desaturase 1 tomitochondria: partial involvement in the apoptotic effect of myristicacid.";
Beauchamp E., Tekpli X., Marteil G., Lagadic-Gossmann D., Legrand P.,Rioux V.;
Biochimie 91:1411-1419(2009).
Cited for: SUBCELLULAR LOCATION, AND MYRISTOYLATION AT GLY-2.
PubMed: 19647031

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND MASSSPECTROMETRY.
PubMed: 18669648