| UniProt ID | NAGPA_HUMAN | |
|---|---|---|
| UniProt AC | Q9UK23 | |
| Protein Name | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | |
| Gene Name | NAGPA | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 515 | |
| Subcellular Localization |
Golgi apparatus, Golgi stack membrane Single-pass type I membrane protein . Golgi apparatus, trans-Golgi network . Cis/medial Golgi. |
|
| Protein Description | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.. | |
| Protein Sequence | MATSTGRWLLLRLALFGFLWEASGGLDSGASRDDDLLLPYPRARARLPRDCTRVRAGNREHESWPPPPATPGAGGLAVRTFVSHFRDRAVAGHLTRAVEPLRTFSVLEPGGPGGCAARRRATVEETARAADCRVAQNGGFFRMNSGECLGNVVSDERRVSSSGGLQNAQFGIRRDGTLVTGYLSEEEVLDTENPFVQLLSGVVWLIRNGSIYINESQATECDETQETGSFSKFVNVISARTAIGHDRKGQLVLFHADGQTEQRGINLWEMAEFLLKQDVVNAINLDGGGSATFVLNGTLASYPSDHCQDNMWRCPRQVSTVVCVHEPRCQPPDCHGHGTCVDGHCQCTGHFWRGPGCDELDCGPSNCSQHGLCTETGCRCDAGWTGSNCSEECPLGWHGPGCQRPCKCEHHCPCDPKTGNCSVSRVKQCLQPPEATLRAGELSFFTRTAWLALTLALAFLLLISTAANLSLLLSRAERNRRLHGDYAYHPLQEMNGEPLAAEKEQPGGAHNPFKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 103 | Phosphorylation | RAVEPLRTFSVLEPG HCCCCCCEEEECCCC | 28.13 | - | |
| 105 | Phosphorylation | VEPLRTFSVLEPGGP CCCCCEEEECCCCCC | 25.77 | - | |
| 126 | Phosphorylation | RRATVEETARAADCR HCCCHHHHHHHHCCE | 14.13 | - | |
| 160 | Phosphorylation | VSDERRVSSSGGLQN ECCCCEECCCCCCCC | 19.58 | 23403867 | |
| 161 | Phosphorylation | SDERRVSSSGGLQNA CCCCEECCCCCCCCC | 30.09 | 23403867 | |
| 162 | Phosphorylation | DERRVSSSGGLQNAQ CCCEECCCCCCCCCE | 29.40 | 23403867 | |
| 208 | N-linked_Glycosylation | GVVWLIRNGSIYINE CEEEEEECCEEEECH | 41.38 | UniProtKB CARBOHYD | |
| 214 | N-linked_Glycosylation | RNGSIYINESQATEC ECCEEEECHHHCCCC | 26.37 | UniProtKB CARBOHYD | |
| 229 | Phosphorylation | DETQETGSFSKFVNV CCCCCCCCHHHHHHH | 33.49 | 24719451 | |
| 296 | N-linked_Glycosylation | GSATFVLNGTLASYP CEEEEEEECEECCCC | 35.78 | UniProtKB CARBOHYD | |
| 365 | Phosphorylation | DELDCGPSNCSQHGL CCCCCCCCCCCCCCE | 35.43 | - | |
| 366 | N-linked_Glycosylation | ELDCGPSNCSQHGLC CCCCCCCCCCCCCEE | 32.37 | UniProtKB CARBOHYD | |
| 368 | Phosphorylation | DCGPSNCSQHGLCTE CCCCCCCCCCCEECC | 29.48 | - | |
| 374 | Phosphorylation | CSQHGLCTETGCRCD CCCCCEECCCCCCCC | 41.44 | - | |
| 376 | Phosphorylation | QHGLCTETGCRCDAG CCCEECCCCCCCCCC | 24.35 | - | |
| 388 | N-linked_Glycosylation | DAGWTGSNCSEECPL CCCCCCCCCCCCCCC | 34.38 | UniProtKB CARBOHYD | |
| 420 | N-linked_Glycosylation | PCDPKTGNCSVSRVK CCCCCCCCCCHHHHH | 21.81 | UniProtKB CARBOHYD | |
| 436 | Phosphorylation | CLQPPEATLRAGELS HCCCCHHEECCCCCC | 18.34 | - | |
| 443 | O-linked_Glycosylation | TLRAGELSFFTRTAW EECCCCCCHHHHHHH | 17.63 | OGP | |
| 446 | O-linked_Glycosylation | AGELSFFTRTAWLAL CCCCCHHHHHHHHHH | 25.71 | OGP | |
| 486 | Phosphorylation | NRRLHGDYAYHPLQE HHHCCCCCCCCCHHH | 17.41 | 28796482 | |
| 488 | Phosphorylation | RLHGDYAYHPLQEMN HCCCCCCCCCHHHHC | 9.57 | 28796482 | |
| 514 | Ubiquitination | GGAHNPFKD------ CCCCCCCCC------ | 64.88 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NAGPA_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NAGPA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NAGPA_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| EPS15_HUMAN | EPS15 | physical | 11723124 | |
| AP2A1_HUMAN | AP2A1 | physical | 11723124 | |
| ZHX2_HUMAN | ZHX2 | physical | 21988832 | |
| NGLY1_HUMAN | NGLY1 | physical | 28514442 | |
| TYW3_HUMAN | TYW3 | physical | 28514442 | |
| UBR3_HUMAN | UBR3 | physical | 28514442 | |
| WDR54_HUMAN | WDR54 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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