| UniProt ID | TYW3_HUMAN | |
|---|---|---|
| UniProt AC | Q6IPR3 | |
| Protein Name | tRNA wybutosine-synthesizing protein 3 homolog | |
| Gene Name | TYW3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 259 | |
| Subcellular Localization | ||
| Protein Description | Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).. | |
| Protein Sequence | MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDRGINGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHSMAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLNVANQKMEENKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYIHKKKRNPEKTRAQCITKESDEELENDDDDDLGINVTIFPEDY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Ubiquitination | SAEFRKWKAQCLSKA CHHHHHHHHHHHCHH | 31.45 | - | |
| 17 | Ubiquitination | WKAQCLSKADLSRKG HHHHHHCHHHHCCCC | 32.73 | - | |
| 23 | Ubiquitination | SKADLSRKGSVDEDV CHHHHCCCCCCCHHH | 52.76 | - | |
| 25 | Phosphorylation | ADLSRKGSVDEDVVE HHHCCCCCCCHHHHH | 29.45 | 28450419 | |
| 99 | Ubiquitination | ANGDATLKFEPFVLH CCCCCEEEEEEEEEE | 43.24 | - | |
| 136 | Acetylation | NSGITVGKRGKTMLA CCCCEECCCCCEEEE | 54.35 | 12435401 | |
| 136 | Ubiquitination | NSGITVGKRGKTMLA CCCCEECCCCCEEEE | 54.35 | - | |
| 157 | Ubiquitination | LEVPLSHKGKLMVTE CCCCCCCCCEEEEEH | 55.13 | - | |
| 207 | Acetylation | TMTNLHPKIKEKNNS HHHCCCHHHHHCCCC | 56.51 | 11794023 | |
| 214 | Phosphorylation | KIKEKNNSSYIHKKK HHHHCCCCCCCCCCC | 33.63 | 22496350 | |
| 216 | Phosphorylation | KEKNNSSYIHKKKRN HHCCCCCCCCCCCCC | 13.58 | - | |
| 227 | Phosphorylation | KKRNPEKTRAQCITK CCCCHHHHHHHEEEC | 29.58 | 28102081 | |
| 233 | Phosphorylation | KTRAQCITKESDEEL HHHHHEEECCCHHHH | 36.06 | 28102081 | |
| 236 | Phosphorylation | AQCITKESDEELEND HHEEECCCHHHHCCC | 52.45 | 26552605 | |
| 253 | Phosphorylation | DDLGINVTIFPEDY- CCCCCEEEECCCCC- | 16.65 | 25841592 | |
| 259 | Phosphorylation | VTIFPEDY------- EEECCCCC------- | 20.84 | 26552605 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TYW3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TYW3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TYW3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KIF3A_HUMAN | KIF3A | physical | 28514442 | |
| KIF2A_HUMAN | KIF2A | physical | 28514442 | |
| GSH1_HUMAN | GCLC | physical | 28514442 | |
| SORL_HUMAN | SORL1 | physical | 28514442 | |
| ZKSC3_HUMAN | ZKSCAN3 | physical | 28514442 | |
| PCBP3_HUMAN | PCBP3 | physical | 28514442 | |
| KIF2C_HUMAN | KIF2C | physical | 28514442 | |
| LEG1_HUMAN | LGALS1 | physical | 28514442 | |
| LDLR_HUMAN | LDLR | physical | 28514442 | |
| DCAF5_HUMAN | DCAF5 | physical | 28514442 | |
| LRP4_HUMAN | LRP4 | physical | 28514442 | |
| BUB1B_HUMAN | BUB1B | physical | 28514442 | |
| FTO_HUMAN | FTO | physical | 28514442 | |
| FBLN1_HUMAN | FBLN1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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