ZKSC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZKSC3_HUMAN
• UniProt AC: Q9BRR0
• Protein Name: Zinc finger protein with KRAB and SCAN domains 3
• Gene Name: ZKSCAN3
• Organism: Homo sapiens (Human).
• Sequence Length: 538
• Subcellular Localization: Nucleus. Cytoplasm. Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.
• Protein Description: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas..
• Protein Sequence: MARELSESTALDAQSTEDQMELLVIKVEEEEAGFPSSPDLGSEGSRERFRGFRYPEAAGPREALSRLRELCRQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPESGEEVVVLLEYLERQLDEPAPQVSGVDQGQELLCCKMALLTPAPGSQSSQFQLMKALLKHESVGSQPLQDRVLQVPVLAHGGCCREDKVVASRLTPESQGLLKVEDVALTLTPEWTQQDSSQGNLCRDEKQENHGSLVSLGDEKQTKSRDLPPAEELPEKEHGKISCHLREDIAQIPTCAEAGEQEGRLQRKQKNATGGRRHICHECGKSFAQSSGLSKHRRIHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMCGKAFRRSSHLLRHQRIHTGDKNVQEPEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNACGKGFTRISYLVQHQRSHVGKNILSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	TEDQMELLVIKVEEE CHHHHEEEEEEEEHH	2.08	29967540
36	Phosphorylation	EEEAGFPSSPDLGSE HHHHCCCCCCCCCCC	52.85	30108239
37	Phosphorylation	EEAGFPSSPDLGSEG HHHCCCCCCCCCCCC	23.75	26657352
42	Phosphorylation	PSSPDLGSEGSRERF CCCCCCCCCCHHHHH	46.19	30108239
45	Phosphorylation	PDLGSEGSRERFRGF CCCCCCCHHHHHCCC	27.24	27732954
54	Phosphorylation	ERFRGFRYPEAAGPR HHHCCCCCCHHCCHH	11.81	20886841
65	Phosphorylation	AGPREALSRLRELCR CCHHHHHHHHHHHHH	36.00	-
82	Methylation	LQPEMHSKEQILELL HCHHHCCHHHHHHHH	38.67	-
171	Ubiquitination	QLMKALLKHESVGSQ HHHHHHHCCCCCCCC	46.29	29967540
171	Sumoylation	QLMKALLKHESVGSQ HHHHHHHCCCCCCCC	46.29	28112733
207	Phosphorylation	KVVASRLTPESQGLL CHHHCCCCHHHCCCE	24.73	28985074
222	Phosphorylation	KVEDVALTLTPEWTQ EEEEEEEEECCHHHH	20.88	-
224	Phosphorylation	EDVALTLTPEWTQQD EEEEEEECCHHHHCC	17.58	-
228	Phosphorylation	LTLTPEWTQQDSSQG EEECCHHHHCCCCCC	18.07	-
322	Phosphorylation	ICHECGKSFAQSSGL HHHHHHHHHHHHCCC	15.88	27251275
326	Phosphorylation	CGKSFAQSSGLSKHR HHHHHHHHCCCCCCC	23.97	27251275
327	Phosphorylation	GKSFAQSSGLSKHRR HHHHHHHCCCCCCCC	31.50	27251275
337	Phosphorylation	SKHRRIHTGEKPYEC CCCCCCCCCCCCCCC	44.67	28111955
365	Phosphorylation	VIHQRVHTGEKPYEC EEEEEECCCCCCEEC	44.15	21712546
391	Phosphorylation	DLIKHQRTHTGEKPY HHHHCCCCCCCCCCE	19.74	-
393	Phosphorylation	IKHQRTHTGEKPYEC HHCCCCCCCCCCEEC	46.56	-
398	Phosphorylation	THTGEKPYECDDCGK CCCCCCCEECCCCCC	40.01	-
412	Phosphorylation	KTFSQSCSLLEHHRI CCHHHHHHHHHCCCC	41.03	28555341
421	Phosphorylation	LEHHRIHTGEKPYQC HHCCCCCCCCCCCCC	44.67	28111955
449	Phosphorylation	LRHQRIHTGDKNVQE HHHCCCCCCCCCCCC	44.71	28112733
465	Phosphorylation	EQGEAWKSRMESQLE CHHHHHHHHHHHHHH	26.59	30631047
469	Phosphorylation	AWKSRMESQLENVET HHHHHHHHHHHCCCC	30.62	30631047
476	Phosphorylation	SQLENVETPMSYKCN HHHHCCCCCCHHCCC	21.73	29978859
479	Phosphorylation	ENVETPMSYKCNECE HCCCCCCHHCCCHHC	23.73	29978859
480	Phosphorylation	NVETPMSYKCNECER CCCCCCHHCCCHHCC	17.20	29978859
503	Phosphorylation	IEHQKIHTGEKPYQC EEEEEEECCCCCCCC	50.97	-
515	Acetylation	YQCNACGKGFTRISY CCCCCCCCCHHHHHH	51.22	7665237
533	Acetylation	HQRSHVGKNILSQ-- HCHHHCCHHHHCC--	39.46	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZKSC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZKSC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZKSC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LZTS2_HUMAN	LZTS2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.