GSH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSH1_HUMAN
• UniProt AC: P48506
• Protein Name: Glutamate--cysteine ligase catalytic subunit
• Gene Name: GCLC
• Organism: Homo sapiens (Human).
• Sequence Length: 637
• Protein Sequence: MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MGLLSQGS -------CCCCCCCC	8.45	20068231
5	Phosphorylation	---MGLLSQGSPLSW ---CCCCCCCCCCCH	37.22	25159151
8	Phosphorylation	MGLLSQGSPLSWEET CCCCCCCCCCCHHHH	18.28	23927012
11	Phosphorylation	LSQGSPLSWEETKRH CCCCCCCCHHHHHHH	35.51	23927012
15	Phosphorylation	SPLSWEETKRHADHV CCCCHHHHHHHHHHH	23.12	22199227
16	Acetylation	PLSWEETKRHADHVR CCCHHHHHHHHHHHH	45.53	19809541
34	Phosphorylation	ILQFLHIYHAVKDRH HHHHHHHHHHHHHHC	3.50	20068231
53	Phosphorylation	KWGDEVEYMLVSFDH HCCCEEEEEEEEEEC	10.83	-
70	Phosphorylation	KKVRLVLSGEKVLET CEEEEEECHHHHHHH	37.11	28355574
73	Ubiquitination	RLVLSGEKVLETLQE EEEECHHHHHHHHHH	56.50	-
81	Ubiquitination	VLETLQEKGERTNPN HHHHHHHHCCCCCCC	53.78	21906983
81	Acetylation	VLETLQEKGERTNPN HHHHHHHHCCCCCCC	53.78	25953088
91	Phosphorylation	RTNPNHPTLWRPEYG CCCCCCCCCCCCCCC	31.25	22210691
99	Phosphorylation	LWRPEYGSYMIEGTP CCCCCCCCEEEECCC	15.61	22210691
100	Phosphorylation	WRPEYGSYMIEGTPG CCCCCCCEEEECCCC	9.57	22210691
105	Phosphorylation	GSYMIEGTPGQPYGG CCEEEECCCCCCCCC	16.08	22210691
161	Ubiquitination	GFTLPEVKPNPVEGG CCCCCCCCCCCCCCC	37.10	-
172	Phosphorylation	VEGGASKSLFFPDEA CCCCCCCCCCCCHHH	28.10	28857561
182	Acetylation	FPDEAINKHPRFSTL CCHHHHHHCCCHHHH	49.20	21466224
187	Phosphorylation	INKHPRFSTLTRNIR HHHCCCHHHHHHCCC	24.64	29449344
188	Phosphorylation	NKHPRFSTLTRNIRH HHCCCHHHHHHCCCC	29.45	24275569
190	Phosphorylation	HPRFSTLTRNIRHRR CCCHHHHHHCCCCCC	23.04	29449344
200	Acetylation	IRHRRGEKVVINVPI CCCCCCCCEEEEEEE	44.63	25953088
209	Ubiquitination	VINVPIFKDKNTPSP EEEEEEECCCCCCCC	69.39	21906983
211	Ubiquitination	NVPIFKDKNTPSPFI EEEEECCCCCCCCCE	64.41	21906983
213	Phosphorylation	PIFKDKNTPSPFIET EEECCCCCCCCCEEC	30.77	23312004
215	Phosphorylation	FKDKNTPSPFIETFT ECCCCCCCCCEECCC	30.33	23312004
220	Phosphorylation	TPSPFIETFTEDDEA CCCCCEECCCCCCHH	30.92	-
222	Phosphorylation	SPFIETFTEDDEASR CCCEECCCCCCHHHH	46.02	-
318	Ubiquitination	ERGLEPLKNNNYRIS HHCCCCCCCCCCCCC	69.24	21906983
322	Phosphorylation	EPLKNNNYRISKSRY CCCCCCCCCCCHHHH	16.08	18767875
329	Phosphorylation	YRISKSRYDSIDSYL CCCCHHHHHHHHHHH	22.57	29978859
331	Phosphorylation	ISKSRYDSIDSYLSK CCHHHHHHHHHHHHH	21.25	28857561
334	Phosphorylation	SRYDSIDSYLSKCGE HHHHHHHHHHHHHCH	26.72	29978859
335	Phosphorylation	RYDSIDSYLSKCGEK HHHHHHHHHHHHCHH	15.96	29978859
337	Phosphorylation	DSIDSYLSKCGEKYN HHHHHHHHHHCHHHC	20.05	29978859
338	Acetylation	SIDSYLSKCGEKYND HHHHHHHHHCHHHCC	43.60	25953088
338	Ubiquitination	SIDSYLSKCGEKYND HHHHHHHHHCHHHCC	43.60	-
342	Ubiquitination	YLSKCGEKYNDIDLT HHHHHCHHHCCCCCE	34.34	-
343	Phosphorylation	LSKCGEKYNDIDLTI HHHHCHHHCCCCCEE	17.48	-
381	Phosphorylation	LFIRDPLTLFEEKIH HHHCCHHHHHHEEEC	34.49	21406692
395	Phosphorylation	HLDDANESDHFENIQ CCCCCCCCCCCCCCC	35.87	-
412	Ubiquitination	NWQTMRFKPPPPNSD CCEEEEECCCCCCCC	46.37	-
464	Phosphorylation	LDFLIPLSKVDENMK CCEEEEHHHCCCCCC	25.86	20068231
465	Ubiquitination	DFLIPLSKVDENMKV CEEEEHHHCCCCCCH	62.48	21906983
488	Acetylation	QGMFYFRKDICKGGN HHHEEECCHHCCCCC	41.36	25953088
492	Acetylation	YFRKDICKGGNAVVD EECCHHCCCCCEEEC	70.91	23749302
492	Malonylation	YFRKDICKGGNAVVD EECCHHCCCCCEEEC	70.91	26320211
560	Acetylation	CSILNYLKLIKKRAS HHHHHHHHHHHHHCC	37.49	25953088
572	Phosphorylation	RASGELMTVARWMRE HCCCHHHHHHHHHHH	24.52	25072903
587	Phosphorylation	FIANHPDYKQDSVIT HHHHCCCCCCCCCCC	18.26	-
621	Phosphorylation	ECPELLGSAFRKVKY CCHHHHHHHHHCCCC	24.97	27050516

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSH0_HUMAN	GCLM	physical	9675072
GSH0_HUMAN	GCLM	physical	9841880
PPID_HUMAN	PPID	physical	22863883
DHR11_HUMAN	DHRS11	physical	26344197
GSH0_HUMAN	GCLM	physical	28514442
NMD3_HUMAN	NMD3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 230450: Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00151: L-Cysteine
• DB00163: Vitamin E