DHR11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHR11_HUMAN
• UniProt AC: Q6UWP2
• Protein Name: Dehydrogenase/reductase SDR family member 11
• Gene Name: DHRS11
• Organism: Homo sapiens (Human).
• Sequence Length: 260
• Subcellular Localization: Secreted .
• Protein Description: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones..
• Protein Sequence: MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	LALVTGASGGIGAAV HHHHHCCCCHHHHHH	38.61	-
44	Phosphorylation	KVVGCARTVGNIEEL EEEEECCEECCHHHH	17.78	27499020
151	Phosphorylation	GHIININSMSGHRVL CCEEEEECCCCCCEE	15.55	29978859
153	Phosphorylation	IININSMSGHRVLPL EEEEECCCCCCEEEE	31.13	29978859
177	Phosphorylation	KYAVTALTEGLRQEL HHHHHHHHHHHHHHH	26.08	24505115
194	Phosphorylation	AQTHIRATCISPGVV HHHHHHHEEECCCEE	10.67	23917254
197	Phosphorylation	HIRATCISPGVVETQ HHHHEEECCCEEEEE	20.11	26657352
220	Phosphorylation	DPEKAAATYEQMKCL CHHHHHHHHHHHHCC	23.90	29083192
221	Phosphorylation	PEKAAATYEQMKCLK HHHHHHHHHHHHCCC	10.23	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHR11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHR11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHR11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYHC_HUMAN	HARS	physical	26344197
PNCB_HUMAN	NAPRT	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
FCL_HUMAN	TSTA3	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.