GTPB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTPB6_HUMAN
• UniProt AC: O43824
• Protein Name: Putative GTP-binding protein 6
• Gene Name: GTPBP6
• Organism: Homo sapiens (Human).
• Sequence Length: 516
• Protein Sequence: MWALRAAVRPGLRLSRVGRGRSAPRAAAPSCPARALAAVGRRSPGNLEGPWGGGRGLRADGGRSRTGDDEEEPEDADENAEEELLRGEPLLPAGTQRVCLVHPDVKWGPGKSQMTRAEWQVAEATALVHTLDGWSVVQTMVVSTKTPDRKLIFGKGNFEHLTEKIRGSPDITCVFLNVERMAAPTKKELEAAWGVEVFDRFTVVLHIFRCNARTKEARLQVALAEMPLHRSNLKRDVAHLYRGVGSRYIMGSGESFMQLQQRLLREKEAKIRKALDRLRKKRHLLRRQRTRREFPVISVVGYTNCGKTTLIKALTGDAAIQPRDQLFATLDVTAHAGTLPSRMTVLYVDTIGFLSQLPHGLIESFSATLEDVAHSDLILHVRDVSHPEAELQKCSVLSTLRGLQLPAPLLDSMVEVHNKVDLVPGYSPTEPNVVPVSALRGHGLQELKAELDAAVLKATGRQILTLRVRLAGAQLSWLYKEATVQEVDVIPEDGAADVRVIISNSAYGKFRKLFPG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	RPGLRLSRVGRGRSA CCCCCEEEECCCCCC	39.23	21890473
42	Methylation	ALAAVGRRSPGNLEG HHHHHCCCCCCCCCC	41.07	-
42	Ubiquitination	ALAAVGRRSPGNLEG HHHHHCCCCCCCCCC	41.07	21890473
43	Phosphorylation	LAAVGRRSPGNLEGP HHHHCCCCCCCCCCC	35.48	23401153
55	Methylation	EGPWGGGRGLRADGG CCCCCCCCCCCCCCC	44.22	-
83	Ubiquitination	ADENAEEELLRGEPL CCCCHHHHHHCCCCC	44.61	-
155	Ubiquitination	DRKLIFGKGNFEHLT CCEEEECCCCHHHHH	39.67	21890473
164	Ubiquitination	NFEHLTEKIRGSPDI CHHHHHHHHCCCCCC	32.25	-
166	Methylation	EHLTEKIRGSPDITC HHHHHHHCCCCCCEE	51.08	-
186	2-Hydroxyisobutyrylation	ERMAAPTKKELEAAW EECCCCCHHHHHHHH	43.10	-
228	Ubiquitination	VALAEMPLHRSNLKR HHHHHCCCCCCCCHH	5.17	-
242	Methylation	RDVAHLYRGVGSRYI HHHHHHHCCCCCHHC	39.41	-
247	Methylation	LYRGVGSRYIMGSGE HHCCCCCHHCCCCHH	21.04	-
280	Ubiquitination	KALDRLRKKRHLLRR HHHHHHHHHHHHHHH	59.77	-
312	Ubiquitination	CGKTTLIKALTGDAA CCHHHHHHHHHCCCC	40.22	-
315	Phosphorylation	TTLIKALTGDAAIQP HHHHHHHHCCCCCCC	37.56	26699800
329	Ubiquitination	PRDQLFATLDVTAHA CHHHEEEEEEEEECC	19.02	21890473
370	Ubiquitination	ESFSATLEDVAHSDL HHHCCCHHHHHCCCE	46.19	21890473
393	Ubiquitination	HPEAELQKCSVLSTL CCHHHHHHCHHHHHH	40.89	-
396	Ubiquitination	AELQKCSVLSTLRGL HHHHHCHHHHHHCCC	7.39	21890473
427	Phosphorylation	VDLVPGYSPTEPNVV CCCCCCCCCCCCCEE	31.12	27050516
448	Ubiquitination	GHGLQELKAELDAAV CCCHHHHHHHHHHHH	38.78	29967540
457	Ubiquitination	ELDAAVLKATGRQIL HHHHHHHHHHCCEEE	36.99	-
503	Phosphorylation	ADVRVIISNSAYGKF CCEEEEEECCCCHHH	17.38	21406692
505	Phosphorylation	VRVIISNSAYGKFRK EEEEEECCCCHHHHH	18.97	21406692
507	Phosphorylation	VIISNSAYGKFRKLF EEEECCCCHHHHHHC	22.22	21406692
509	Ubiquitination	ISNSAYGKFRKLFPG EECCCCHHHHHHCCC	29.35	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GTPB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTPB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTPB6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GTPB6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.