NSUN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSUN3_HUMAN
• UniProt AC: Q9H649
• Protein Name: tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
• Gene Name: NSUN3 {ECO:0000312|HGNC:HGNC:26208}
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). [PubMed: 27497299]
• Protein Sequence: MLTQLKAKSEGKLAKQICKVVLDHFEKQYSKELGDAWNTVREILTSPSCWQYAVLLNRFNYPFELEKDLHLKGYHTLSQGSLPNYPKSVKCYLSRTPGRIPSERHQIGNLKKYYLLNAASLLPVLALELRDGEKVLDLCAAPGGKSIALLQCACPGYLHCNEYDSLRLRWLRQTLESFIPQPLINVIKVSELDGRKMGDAQPEMFDKVLVDAPCSNDRSWLFSSDSQKASCRISQRRNLPLLQIELLRSAIKALRPGGILVYSTCTLSKAENQDVISEILNSHGNIMPMDIKGIARTCSHDFTFAPTGQECGLLVIPDKGKAWGPMYVAKLKKSWSTGKW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MLTQLKAKSEGKL --CCHHHHHHCCHHH	43.90	29967540
8	Ubiquitination	MLTQLKAKSEGKLAK CCHHHHHHCCHHHHH	47.67	29967540
9	Phosphorylation	LTQLKAKSEGKLAKQ CHHHHHHCCHHHHHH	57.34	20068231
27	Ubiquitination	VVLDHFEKQYSKELG HHHHHHHHHHHHHHH	54.30	29967540
67	Ubiquitination	NYPFELEKDLHLKGY CCCCEECCCCCCCCC	77.53	21890473
72	Ubiquitination	LEKDLHLKGYHTLSQ ECCCCCCCCCEECCC	46.83	22817900
74	Phosphorylation	KDLHLKGYHTLSQGS CCCCCCCCEECCCCC	7.05	29978859
76	Phosphorylation	LHLKGYHTLSQGSLP CCCCCCEECCCCCCC	21.44	29978859
78	Phosphorylation	LKGYHTLSQGSLPNY CCCCEECCCCCCCCC	33.38	29978859
81	Phosphorylation	YHTLSQGSLPNYPKS CEECCCCCCCCCCCC	32.77	29978859
85	Phosphorylation	SQGSLPNYPKSVKCY CCCCCCCCCCCEEEH	15.31	29978859
87	Ubiquitination	GSLPNYPKSVKCYLS CCCCCCCCCEEEHHH	58.48	29967540
88	Phosphorylation	SLPNYPKSVKCYLSR CCCCCCCCEEEHHHC	23.46	29978859
90	Ubiquitination	PNYPKSVKCYLSRTP CCCCCCEEEHHHCCC	25.01	29967540
92	Phosphorylation	YPKSVKCYLSRTPGR CCCCEEEHHHCCCCC	11.29	29978859
94	Phosphorylation	KSVKCYLSRTPGRIP CCEEEHHHCCCCCCC	13.97	29978859
102	Phosphorylation	RTPGRIPSERHQIGN CCCCCCCCHHHCCCC	44.91	24719451
111	Ubiquitination	RHQIGNLKKYYLLNA HHCCCCCHHHHHHHH	42.61	29967540
113	Phosphorylation	QIGNLKKYYLLNAAS CCCCCHHHHHHHHHH	9.58	20068231
114	Phosphorylation	IGNLKKYYLLNAASL CCCCHHHHHHHHHHH	17.37	20068231
120	Phosphorylation	YYLLNAASLLPVLAL HHHHHHHHHHHHHHE	28.20	20068231
190	Phosphorylation	LINVIKVSELDGRKM CEEEEEHHHCCCCCC	27.69	24719451
207	Ubiquitination	AQPEMFDKVLVDAPC CCHHHCCEEEEECCC	26.63	29967540
303	Phosphorylation	RTCSHDFTFAPTGQE HHCCCCEEECCCCCC	25.58	-
307	Phosphorylation	HDFTFAPTGQECGLL CCEEECCCCCCEEEE	48.33	-
319	Ubiquitination	GLLVIPDKGKAWGPM EEEEECCCCCCCCCE	57.89	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSUN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSUN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSUN3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NSUN3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.