dbPTM

NTCP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NTCP7_HUMAN
UniProt AC	Q0GE19
Protein Name	Sodium/bile acid cotransporter 7
Gene Name	SLC10A7
Organism	Homo sapiens (Human).
Sequence Length	340
Subcellular Localization	Cell membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate)..
Protein Sequence	MRLLERMRKDWFMVGIVLAIAGAKLEPSIGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLILFIIFSIQLSFMLLTFIFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLLIYHPAQILLGSVLVPTIKSWMVSRQKGVKLTRPTV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	IFFNSGLSLKTEELT HHHCCCCCCCHHHHH	31.20	24719451
351	Phosphorylation	------------------ ------------------	15.70	27642862
351 (in isoform 1)	Phosphorylation	-	15.70	24173317
353	Phosphorylation	-------------------- --------------------	23.88	-
353 (in isoform 1)	Phosphorylation	-	23.88	24173317
355	Ubiquitination	---------------------- ----------------------	41.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NTCP7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NTCP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NTCP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
D19L4_HUMAN	DPY19L4	physical	28514442
VA0D1_HUMAN	ATP6V0D1	physical	28514442
ECM29_HUMAN	KIAA0368	physical	28514442
APOB_HUMAN	APOB	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NTCP7_HUMAN

Related Literatures of Post-Translational Modification