D19L4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: D19L4_HUMAN
• UniProt AC: Q7Z388
• Protein Name: Probable C-mannosyltransferase DPY19L4
• Gene Name: DPY19L4
• Organism: Homo sapiens (Human).
• Sequence Length: 723
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins..
• Protein Sequence: MAEEEGPPVELRQRKKPKSSENKESAKEEKISDIPIPERAPKHVLFQRFAKIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMSLYPELIASILYQATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLRENWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDKVYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQLNVKKGSFVAKIIKVINFYLVCTLTITLNIIMKMFVPHKENGHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLKETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILSMAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHEVKINYSPYVNYFTRVYWNRSYFVYKINTVISFQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEEEGPPV ------CCCCCCCCC	32.67	22814378
42	Ubiquitination	PIPERAPKHVLFQRF CCCCCCCHHHHHHHH	45.41	-
104	Ubiquitination	AIYYSYYKDMLKAPS EEEEEEHHHHHCCCC	28.55	-
108	Ubiquitination	SYYKDMLKAPSFERG EEHHHHHCCCCHHCC	52.17	21906983
213	Phosphorylation	DTTRIEYSIPLRENW CCCEEEEEEECCCCC	12.63	24719451
450	Ubiquitination	RINGKSLKETVTLED HHCCCCHHEEEEECC	59.43	21906983
623	Ubiquitination	NIYQIYSKRSAEDIY CHHHHHHHCCHHHHH	33.14	-
682	Ubiquitination	GDKLTYSKYGRFCHE CCEEEECCCCCCCCE	41.11	-
683	Phosphorylation	DKLTYSKYGRFCHEV CEEEECCCCCCCCEE	13.95	-
697	Phosphorylation	VKINYSPYVNYFTRV EECCCCCCCCCEEEE	8.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of D19L4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of D19L4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of D19L4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of D19L4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.