UFSP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UFSP2_HUMAN
• UniProt AC: Q9NUQ7
• Protein Name: Ufm1-specific protease 2
• Gene Name: UFSP2
• Organism: Homo sapiens (Human).
• Sequence Length: 469
• Subcellular Localization: Cytoplasm. Endoplasmic reticulum. Nucleus.
• Protein Description: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation..
• Protein Sequence: MVISESMDILFRIRGGLDLAFQLATPNEIFLKKALKHVLSDLSTKLSSNALVFRICHSSVYIWPSSDINTIPGELTDASACKNILRFIQFEPEEDIKRKFMRKKDKKLSDMHQIVNIDLMLEMSTSLAAVTPIIERESGGHHYVNMTLPVDAVISVAPEETWGKVRKLLVDAIHNQLTDMEKCILKYMKGTSIVVPEPLHFLLPGKKNLVTISYPSGIPDGQLQAYRKELHDLFNLPHDRPYFKRSNAYHFPDEPYKDGYIRNPHTYLNPPNMETGMIYVVQGIYGYHHYMQDRIDDNGWGCAYRSLQTICSWFKHQGYTERSIPTHREIQQALVDAGDKPATFVGSRQWIGSIEVQLVLNQLIGITSKILFVSQGSEIASQGRELANHFQSEGTPVMIGGGVLAHTILGVAWNEITGQIKFLILDPHYTGAEDLQVILEKGWCGWKGPDFWNKDAYYNLCLPQRPNMI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVISESMD -------CCCCCCHH	5.65	25732826
36	Ubiquitination	IFLKKALKHVLSDLS HHHHHHHHHHHHHHH	36.21	-
36	Malonylation	IFLKKALKHVLSDLS HHHHHHHHHHHHHHH	36.21	26320211
97	Ubiquitination	FEPEEDIKRKFMRKK CCCHHHHHHHHHHHH	62.95	21906983
97	2-Hydroxyisobutyrylation	FEPEEDIKRKFMRKK CCCHHHHHHHHHHHH	62.95	-
99	Ubiquitination	PEEDIKRKFMRKKDK CHHHHHHHHHHHHCC	38.21	-
155	Phosphorylation	LPVDAVISVAPEETW EECCEEEEECCHHHH	12.96	-
161	Phosphorylation	ISVAPEETWGKVRKL EEECCHHHHHHHHHH	37.54	-
178	Phosphorylation	DAIHNQLTDMEKCIL HHHHHHCCHHHHHHH	24.44	-
206	2-Hydroxyisobutyrylation	LHFLLPGKKNLVTIS HHHHCCCCCCEEEEE	36.23	-
228	Ubiquitination	GQLQAYRKELHDLFN HHHHHHHHHHHHHHC	52.53	-
240	Methylation	LFNLPHDRPYFKRSN HHCCCCCCCCCCCCC	25.45	115919509
244	Ubiquitination	PHDRPYFKRSNAYHF CCCCCCCCCCCCCCC	49.42	-
246	Phosphorylation	DRPYFKRSNAYHFPD CCCCCCCCCCCCCCC	26.80	28857561
267	Phosphorylation	YIRNPHTYLNPPNME CCCCCCCCCCCCCCC	11.05	-
279	Phosphorylation	NMETGMIYVVQGIYG CCCCCCEEEEEEEHH	5.91	-
285	Phosphorylation	IYVVQGIYGYHHYMQ EEEEEEEHHHHHHHC	20.61	-
287	Phosphorylation	VVQGIYGYHHYMQDR EEEEEHHHHHHHCCC	2.89	-
377	Phosphorylation	ILFVSQGSEIASQGR EEEEECCHHHHHHHH	20.42	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UFSP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UFSP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UFSP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASCC1_HUMAN	ASCC1	physical	25219498
ODR4_HUMAN	C1orf27	physical	28162770

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.