PEX6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX6_HUMAN
• UniProt AC: Q13608
• Protein Name: Peroxisome assembly factor 2
• Gene Name: PEX6
• Organism: Homo sapiens (Human).
• Sequence Length: 980
• Subcellular Localization: Cytoplasm. Peroxisome membrane . Cell projection, cilium, photoreceptor outer segment . Associated with peroxisomal membranes. Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283).
• Protein Description: Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes..
• Protein Sequence: MALAVLRVLEPFPTETPPLAVLLPPGGPWPAAELGLVLALRPAGESPAGPALLVAALEGPDAGTEEQGPGPPQLLVSRALLRLLALGSGAWVRARAVRRPPALGWALLGTSLGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRARLCPESGDSSRPPPPPVVSSFAVSGTVRRLQGVLGGTGDSLGVSRSCLRGLGLFQGEWVWVAQARESSNTSQPHLARVQVLEPRWDLSDRLGPGSGPLGEPLADGLALVPATLAFNLGCDPLEMGELRIQRYLEGSIAPEDKGSCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGSTLSPVPWLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	GPPQLLVSRALLRLL CCHHHHHHHHHHHHH	16.29	24719451
93	Dimethylation	LGSGAWVRARAVRRP HCCCHHHHHHHHCCC	13.98	-
93	Methylation	LGSGAWVRARAVRRP HCCCHHHHHHHHCCC	13.98	24379809
95	Dimethylation	SGAWVRARAVRRPPA CCHHHHHHHHCCCCC	24.05	-
95	Methylation	SGAWVRARAVRRPPA CCHHHHHHHHCCCCC	24.05	24379817
119	Methylation	LGPGLGPRVGPLLVR CCCCCCCCCCCEEEE	44.20	24129315
161	Methylation	RLAVTELRGRARLCP EEEEEEECCCCCCCC	26.73	80702255
201 (in isoform 3)	Phosphorylation	-	35.70	20860994
306	Ubiquitination	GSIAPEDKGSCSLLP CCCCCCCCCCCCCCC	51.57	-
371	Phosphorylation	QVEILEGSPEKLPRW EEEECCCCCCCCHHH	22.10	24719451
374	Ubiquitination	ILEGSPEKLPRWREM ECCCCCCCCHHHHHH	68.15	-
701	Phosphorylation	VGAPKIPSVSWHDVG CCCCCCCCCCHHCCC	32.05	27050516
714	Ubiquitination	VGGLQEVKKEILETI CCCHHHHHHHHHHHC	43.89	-
715	Ubiquitination	GGLQEVKKEILETIQ CCHHHHHHHHHHHCC	55.98	-
750	Ubiquitination	HGPPGTGKTLLAKAV CCCCCCCHHHHHHHH	35.52	-
961	Phosphorylation	AAARLQPSVSEQELL HHHHHCCCCCHHHHH	25.89	30622161
963	Phosphorylation	ARLQPSVSEQELLRY HHHCCCCCHHHHHHH	37.59	30622161
970	Phosphorylation	SEQELLRYKRIQRKF CHHHHHHHHHHHHHH	12.46	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEX6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEX6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX1_HUMAN	PEX1	physical	9588209
PEX1_HUMAN	PEX1	physical	9671729
RS14_HUMAN	RPS14	physical	21988832
RL27A_HUMAN	RPL27A	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.