TRM44_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRM44_HUMAN
• UniProt AC: Q8IYL2
• Protein Name: Probable tRNA (uracil-O(2)-)-methyltransferase
• Gene Name: TRMT44
• Organism: Homo sapiens (Human).
• Sequence Length: 757
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase..
• Protein Sequence: MAEVGRTGISYPGALLPQGFWAAVEVWLERPQVANKRLCGARLEARWSAALPCAEARGPGTSAGSEQKERGPGPGQGSPGGGPGPRSLSGPEQGTACCELEEAQGQCQQEEAQREAASVPLRDSGHPGHAEGREGDFPAADLDSLWEDFSQSLARGNSELLAFLTSSGAGSQPEAQRELDVVLRTVIPKTSPHCPLTTPRREIVVQDVLNGTITFLPLEEDDEGNLKVKMSNVYQIQLSHSKEEWFISVLIFCPERWHSDGIVYPKPTWLGEELLAKLAKWSVENKKSDFKSTLSLISIMKYSKAYQELKEKYKEMVKVWPEVTDPEKFVYEDVAIAAYLLILWEEERAERRLTARQSFVDLGCGNGLLVHILSSEGHPGRGIDVRRRKIWDMYGPQTQLEEDAITPNDKTLFPDVDWLIGNHSDELTPWIPVIAARSSYNCRFFVLPCCFFDFIGRYSRRQSKKTQYREYLDFIKEVGFTCGFHVDEDCLRIPSTKRVCLVGKSRTYPSSREASVDEKRTQYIKSRRGCPVSPPGWELSPSPRWVAAGSAGHCDGQQALDARVGCVTRAWAAEHGAGPQAEGPWLPGFHPREKAERVRNCAALPRDFIDQVVLQVANLLLGGKQLNTRSSRNGSLKTWNGGESLSLAEVANELDTETLRRLKRECGGLQTLLRNSHQVFQVVNGRVHIRDWREETLWKTKQPEAKQRLLSEACKTRLCWFFMHHPDGCALSTDCCPFAHGPAELRPPRTTPRKKIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Ubiquitination	ARGPGTSAGSEQKER HCCCCCCCCCCCCCC	25.93	27667366
65	Phosphorylation	GPGTSAGSEQKERGP CCCCCCCCCCCCCCC	36.25	24719451
68 (in isoform 1)	Ubiquitination	-	45.38	21906983
68	Ubiquitination	TSAGSEQKERGPGPG CCCCCCCCCCCCCCC	45.38	22817900
75	Ubiquitination	KERGPGPGQGSPGGG CCCCCCCCCCCCCCC	50.85	27667366
78	Phosphorylation	GPGPGQGSPGGGPGP CCCCCCCCCCCCCCC	16.69	29255136
87	Phosphorylation	GGGPGPRSLSGPEQG CCCCCCCCCCCCCCC	29.98	26074081
89	Phosphorylation	GPGPRSLSGPEQGTA CCCCCCCCCCCCCCC	54.25	26074081
118	Phosphorylation	EAQREAASVPLRDSG HHHHHHHCCCCCCCC	31.17	22985185
148 (in isoform 2)	Ubiquitination	-	36.59	21906983
148	Ubiquitination	DLDSLWEDFSQSLAR HHHHHHHHHHHHHHC	36.59	22817900
160	Ubiquitination	LARGNSELLAFLTSS HHCCCHHHHHHHHCC	4.14	22817900
189	Ubiquitination	VLRTVIPKTSPHCPL EEEECCCCCCCCCCC	50.97	-
197	Phosphorylation	TSPHCPLTTPRREIV CCCCCCCCCCCCEEE	21.64	24719451
227	Ubiquitination	EDDEGNLKVKMSNVY CCCCCCEEEEEEEEE	43.75	32015554
248	Phosphorylation	SKEEWFISVLIFCPE CCCCEEEEEEEECCH	11.03	27732954
263	Ubiquitination	RWHSDGIVYPKPTWL HHCCCCCCCCCCCCC	9.05	27667366
275	Ubiquitination	TWLGEELLAKLAKWS CCCCHHHHHHHHHHH	4.46	27667366
280	Ubiquitination	ELLAKLAKWSVENKK HHHHHHHHHHHHCCC	50.90	29967540
286	Ubiquitination	AKWSVENKKSDFKST HHHHHHCCCCHHHHH	39.90	29967540
287	Ubiquitination	KWSVENKKSDFKSTL HHHHHCCCCHHHHHH	67.83	-
304	Ubiquitination	ISIMKYSKAYQELKE HHHHHHHHHHHHHHH	48.28	27667366
306	Phosphorylation	IMKYSKAYQELKEKY HHHHHHHHHHHHHHH	13.27	29496907
310	Ubiquitination	SKAYQELKEKYKEMV HHHHHHHHHHHHHHH	51.94	-
318	Ubiquitination	EKYKEMVKVWPEVTD HHHHHHHHHCCCCCC	36.95	29967540
389 (in isoform 1)	Ubiquitination	-	46.46	21906983
389	Ubiquitination	GIDVRRRKIWDMYGP CCCHHHHHHHHHHCC	46.46	22817900
504	Ubiquitination	KRVCLVGKSRTYPSS CEEEEEECCCCCCCC	29.32	27667366
505	Phosphorylation	RVCLVGKSRTYPSSR EEEEEECCCCCCCCC	24.75	26552605
507	Phosphorylation	CLVGKSRTYPSSREA EEEECCCCCCCCCCC	47.04	27251275
508	Phosphorylation	LVGKSRTYPSSREAS EEECCCCCCCCCCCC	10.45	27251275
510	Phosphorylation	GKSRTYPSSREASVD ECCCCCCCCCCCCCC	31.45	26552605
511	Phosphorylation	KSRTYPSSREASVDE CCCCCCCCCCCCCCH	29.63	26552605
515	Phosphorylation	YPSSREASVDEKRTQ CCCCCCCCCCHHHHH	25.91	27251275
519	Ubiquitination	REASVDEKRTQYIKS CCCCCCHHHHHHHHH	57.17	29967540
521	Phosphorylation	ASVDEKRTQYIKSRR CCCCHHHHHHHHHHC	36.47	-
526	Phosphorylation	KRTQYIKSRRGCPVS HHHHHHHHHCCCCCC	20.04	-
533	Phosphorylation	SRRGCPVSPPGWELS HHCCCCCCCCCCCCC	15.54	28348404
540	Phosphorylation	SPPGWELSPSPRWVA CCCCCCCCCCCCEEE	16.30	26074081
542	Phosphorylation	PGWELSPSPRWVAAG CCCCCCCCCCEEECC	24.58	17081983
628	Phosphorylation	LGGKQLNTRSSRNGS HCCCCCCCCCCCCCC	40.29	20166139
630	Phosphorylation	GKQLNTRSSRNGSLK CCCCCCCCCCCCCCC	31.45	20166139
631	Phosphorylation	KQLNTRSSRNGSLKT CCCCCCCCCCCCCCE	26.86	29052541
635	Phosphorylation	TRSSRNGSLKTWNGG CCCCCCCCCCEECCC	30.18	20166139
644	Phosphorylation	KTWNGGESLSLAEVA CEECCCCCCCHHHHH	26.91	-
646	Phosphorylation	WNGGESLSLAEVANE ECCCCCCCHHHHHHH	34.51	-
658	Phosphorylation	ANELDTETLRRLKRE HHHCCHHHHHHHHHH	27.88	-
715	Ubiquitination	RLLSEACKTRLCWFF HHHHHHHHHHHHHHH	43.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRM44_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRM44_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRM44_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TRM44_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.