PRAM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRAM_HUMAN
• UniProt AC: Q96QH2
• Protein Name: PML-RARA-regulated adapter molecule 1
• Gene Name: PRAM1
• Organism: Homo sapiens (Human).
• Sequence Length: 670
• Protein Description: May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P..
• Protein Sequence: MAHHLPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPQVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDVDFCDPLENQPLPLGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	HLPAAMESHQDFRSI CHHHHHHHHHCHHHH	17.23	25002506
25	Phosphorylation	IKAKFQASQPEPSDL HHHHHHHCCCCCCCC	35.17	23532336
38	Acetylation	DLPKKPPKPEFGKLK CCCCCCCCCCCCCCC	66.75	19608861
48	Phosphorylation	FGKLKKFSQPELSEH CCCCCCCCCHHHHCC	54.42	28450419
120	Phosphorylation	TDLPKKPSKLELSDL CCCCCCCCCCCHHHH	66.99	27251275
168	Phosphorylation	GAPARKPLQPDELSH CCCCCCCCCCCCCCC	59.77	27251275
174	Phosphorylation	PLQPDELSHPARPPS CCCCCCCCCCCCCCC	68.53	-
185	Phosphorylation	RPPSEPKSGAFPRKL CCCCCCCCCCCCCCC	24.54	24114839
204	Phosphorylation	AGEATPRSPQPELST CCCCCCCCCCCCHHC	42.76	27251275
222	Phosphorylation	KPAQPEFNVYPKKPP CCCCCCCCCCCCCCC	25.94	-
249	Phosphorylation	PQPEFSEAAQTPLWK CCHHHHHHHCCCCCC	18.22	28450419
252	Phosphorylation	EFSEAAQTPLWKPQS HHHHHHCCCCCCCCC	29.14	23401153
258	Phosphorylation	QTPLWKPQSSEPKRD CCCCCCCCCCCCCCC	26.75	22115753
259	Phosphorylation	TPLWKPQSSEPKRDS CCCCCCCCCCCCCCC	57.49	22115753
272	Phosphorylation	DSSAFPKKASQPPLS CCCCCCCCCCCCCHH	15.50	26546556
297	Phosphorylation	LGDLTRTSSEPEVSV CCCCCCCCCCCCCCC	12.04	20058876
298	Phosphorylation	GDLTRTSSEPEVSVL CCCCCCCCCCCCCCC	15.10	24719451
300	Phosphorylation	LTRTSSEPEVSVLPK CCCCCCCCCCCCCCC	18.67	25003641
332	Phosphorylation	ELGGLPRTSSEPEFN CCCCCCCCCCCCCHH	63.27	20058876
333	Phosphorylation	LGGLPRTSSEPEFNS CCCCCCCCCCCCHHC	38.59	20058876
334	Phosphorylation	GGLPRTSSEPEFNSL CCCCCCCCCCCHHCC	71.84	24719451
340	Phosphorylation	SSEPEFNSLPRKLLQ CCCCCHHCCCHHHHC	58.45	20058876
344	Phosphorylation	EFNSLPRKLLQPERR CHHCCCHHHHCHHHH	31.22	28450419
345	Phosphorylation	FNSLPRKLLQPERRG HHCCCHHHHCHHHHC	29.43	28450419
346	Phosphorylation	NSLPRKLLQPERRGP HCCCHHHHCHHHHCC	57.46	20058876
358	Phosphorylation	RGPPRKFSQPEPSAV HCCCCCCCCCCCCHH	47.28	24719451
380	Phosphorylation	EFFGDLPRKPPLPSS CCCCCCCCCCCCCCC	34.36	28450419
381	Phosphorylation	FFGDLPRKPPLPSSA CCCCCCCCCCCCCCC	33.70	28450419
382	Phosphorylation	FGDLPRKPPLPSSAS CCCCCCCCCCCCCCC	57.46	23401153
388	Phosphorylation	KPPLPSSASESSLPA CCCCCCCCCCCCCCH	45.10	23401153
389	Phosphorylation	PPLPSSASESSLPAA CCCCCCCCCCCCCHH	5.09	24719451
391	Phosphorylation	LPSSASESSLPAAVA CCCCCCCCCCCHHHH	47.77	27251275
392	Phosphorylation	PSSASESSLPAAVAG CCCCCCCCCCHHHHC	52.16	27251275
404	Acetylation	VAGFSSRHPLSPGFG HHCCCCCCCCCCCCC	55.96	-
406	Phosphorylation	GFSSRHPLSPGFGAA CCCCCCCCCCCCCCC	48.11	23401153
407	Phosphorylation	FSSRHPLSPGFGAAG CCCCCCCCCCCCCCC	49.89	24719451
411	Phosphorylation	HPLSPGFGAAGTPRW CCCCCCCCCCCCCCC	29.37	28857561
420	Phosphorylation	AGTPRWRSGGLVHSG CCCCCCCCCCCCCCC	44.83	27251275
429	Acetylation	GLVHSGGARPGLRPS CCCCCCCCCCCCCCC	49.39	-
434	Phosphorylation	GGARPGLRPSHPPRR CCCCCCCCCCCCCCC	46.34	28450419
435	Phosphorylation	GARPGLRPSHPPRRR CCCCCCCCCCCCCCC	33.60	26657352
437	Phosphorylation	RPGLRPSHPPRRRPL CCCCCCCCCCCCCCC	39.70	28450419
439	Phosphorylation	GLRPSHPPRRRPLPP CCCCCCCCCCCCCCC	34.38	28450419
440	Phosphorylation	LRPSHPPRRRPLPPA CCCCCCCCCCCCCCH	34.03	28450419
449	Phosphorylation	RPLPPASSLGHPPAK CCCCCHHHCCCCCCC	26.08	27486199
450	Phosphorylation	PLPPASSLGHPPAKP CCCCHHHCCCCCCCC	32.14	27486199
455	Phosphorylation	SSLGHPPAKPPLPPG HHCCCCCCCCCCCCC	27.68	28857561
463	Phosphorylation	KPPLPPGPVDMQSFR CCCCCCCCCCHHHCC	12.64	28450419
468	Phosphorylation	PGPVDMQSFRRPSAA CCCCCHHHCCCCCCC	30.19	23401153
473	Phosphorylation	MQSFRRPSAASIDLR HHHCCCCCCCEEECH	26.26	24719451
476	Phosphorylation	FRRPSAASIDLRRTR CCCCCCCEEECHHHH	22.79	27251275
484	Phosphorylation	IDLRRTRSAAGLHFQ EECHHHHHHCCCCCC	42.04	24719451
496	Phosphorylation	HFQDRQPEDIPQVPD CCCCCCCCCCCCCCH	31.69	-
497	Phosphorylation	FQDRQPEDIPQVPDE CCCCCCCCCCCCCHH	40.24	-
516	Phosphorylation	YDDVEPRDDSSPSPK HHCCCCCCCCCCCCC	17.68	25003641
521	Phosphorylation	PRDDSSPSPKGRDEA CCCCCCCCCCCCCCC	34.36	26074081
524	Phosphorylation	DSSPSPKGRDEAPSV CCCCCCCCCCCCHHH	19.15	26074081
530	Phosphorylation	KGRDEAPSVQQAARR CCCCCCHHHHHHHHC	23.65	26657352
532	Phosphorylation	RDEAPSVQQAARRPP CCCCHHHHHHHHCCC	23.12	23401153
554	Phosphorylation	EKDPQPQQLPPMDPK CCCCCCCCCCCCCHH	9.61	22115753
557	Phosphorylation	PQPQQLPPMDPKLLK CCCCCCCCCCHHHHH	9.73	22115753
566	Phosphorylation	DPKLLKQLRKAEKAE CHHHHHHHHHHHHHH	48.73	28450419
567	Phosphorylation	PKLLKQLRKAEKAER HHHHHHHHHHHHHHH	36.07	26434552
569	Phosphorylation	LLKQLRKAEKAEREF HHHHHHHHHHHHHHH	40.99	28450419
700	Phosphorylation	------------------------------------- -------------------------------------	10.53	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRAM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRAM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRAM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LCP2_HUMAN	LCP2	physical	11301322
SKAP2_HUMAN	SKAP2	physical	11301322
LYN_HUMAN	LYN	physical	11301322
NCOR1_HUMAN	NCOR1	physical	16730330
HDAC3_HUMAN	HDAC3	physical	16730330
SUV91_HUMAN	SUV39H1	physical	16449642
MBD1_HUMAN	MBD1	physical	16432238
RNF32_HUMAN	RNF32	physical	21163940
K1C40_HUMAN	KRT40	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.