HPS3_HUMAN - dbPTM
HPS3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HPS3_HUMAN
UniProt AC Q969F9
Protein Name Hermansky-Pudlak syndrome 3 protein
Gene Name HPS3
Organism Homo sapiens (Human).
Sequence Length 1004
Subcellular Localization Cytoplasm . Cytoplasm, cytosol .
Protein Description Involved in early stages of melanosome biogenesis and maturation..
Protein Sequence MVQLYNLHPFGSQQVVPCKLEPDRFCGGGRDALFVAAGCKVEAFAVAGQELCQPRCAFSTLGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRNKRTENSRVCIRMIGHNVEGPFSKAFRDQMYIIEMPLSEAPLCISCCPVKGDLLVGCTNKLVLFSLKYQIINEEFSLLDFERSLIIHIDNITPVEVSFCVGYVAVMSDLEVLIVKLESGPKNGERVHHHPHKTNNRIRRTEEGISNEISQLESDDFVICQKPLELLGEKSEQSGLSVTLESTGLADEKRKYSHFQHLLYRRFAPDISSYVLSDDIKLHSLQLLPIYQTGSLTSDGKNLSQEKELLSLFCFFSLPHVGYLYMVVKSVELMSVYQYPEKSQQAVLTPQFLHVITSNNLQCFTVRCSAAAAREEDPYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEAIPERRQSPKRLLSRKDTSVKIKIPPVAEAGWNLYIVNTISPVQLYKEMVDYSNTYKTVKTQSCIHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLDSQHSHLTLPYYKMSGLSMAEVLARTDWTVEDGLQKYERGLIFYINHSLYENLDEELNEELAAKVVQMFYVAEPKQVPHILCSPSMKNINPLTAMSYLRKLDTSGFSSILVTLTKAAVALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTELALHLKETQPGLLVASVLGLQKNNKIGIEEADSFFKVLCAKDEDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINACSHYGLIYPWVHVVISSDSLADKNYTEDLSKLQSLICGPSFDIASIIPFLEPLSEDTIAGLSVHVLCRTRLKEYEQCIDILLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSSLKETLSIVAVELELKDFMNVLPEDGTATFFLPYLLYCSRKKPLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MVQLYNLHPFGS
---CCEEEECCCCCC		9.8924043423
12PhosphorylationYNLHPFGSQQVVPCK
EECCCCCCCCEEECC		20.1624043423
19UbiquitinationSQQVVPCKLEPDRFC
CCCEEECCCCCCCCC		50.22-
160PhosphorylationTNKLVLFSLKYQIIN
CCCCHHHEEEHHHHC		21.5724719451
227UbiquitinationRVHHHPHKTNNRIRR
CCCCCCCCCCCHHHH		58.35-
256UbiquitinationDDFVICQKPLELLGE
CCEEEECCCHHHHCC		47.35-
265PhosphorylationLELLGEKSEQSGLSV
HHHHCCCCCCCCCEE		36.2422199227
268PhosphorylationLGEKSEQSGLSVTLE
HCCCCCCCCCEEEEE		37.3422199227
271PhosphorylationKSEQSGLSVTLESTG
CCCCCCCEEEEEECC		19.3122199227
273PhosphorylationEQSGLSVTLESTGLA
CCCCCEEEEEECCCC		22.7922199227
276PhosphorylationGLSVTLESTGLADEK
CCEEEEEECCCCCHH		30.7822199227
277PhosphorylationLSVTLESTGLADEKR
CEEEEEECCCCCHHH		27.1722199227
283UbiquitinationSTGLADEKRKYSHFQ
ECCCCCHHHHHHHHH		55.53-
283AcetylationSTGLADEKRKYSHFQ
ECCCCCHHHHHHHHH		55.5330589347
285AcetylationGLADEKRKYSHFQHL
CCCCHHHHHHHHHHH		63.2730589353
285UbiquitinationGLADEKRKYSHFQHL
CCCCHHHHHHHHHHH		63.27-
302PhosphorylationRRFAPDISSYVLSDD
HHHCCCHHHHHCCCC		24.0128796482
303PhosphorylationRFAPDISSYVLSDDI
HHCCCHHHHHCCCCC		21.4228796482
304PhosphorylationFAPDISSYVLSDDIK
HCCCHHHHHCCCCCE		9.9128796482
307PhosphorylationDISSYVLSDDIKLHS
CHHHHHCCCCCEECE		24.1628796482
331UbiquitinationGSLTSDGKNLSQEKE
CCCCCCCCCHHHHHH		60.76-
409PhosphorylationAAREEDPYMDTTLKA
HHCCCCCCCCCCCCC		21.6827642862
462PhosphorylationAIPERRQSPKRLLSR
HCCCCCCCCCHHHCC		30.4925849741
468PhosphorylationQSPKRLLSRKDTSVK
CCCCHHHCCCCCCCE		41.7122817900
472PhosphorylationRLLSRKDTSVKIKIP
HHHCCCCCCCEEECC		38.1522817900
473PhosphorylationLLSRKDTSVKIKIPP
HHCCCCCCCEEECCC		31.39-
509PhosphorylationEMVDYSNTYKTVKTQ
HHHCCCCCCCEECHH		22.0623828894
511UbiquitinationVDYSNTYKTVKTQSC
HCCCCCCCEECHHHH		44.82-
511AcetylationVDYSNTYKTVKTQSC
HCCCCCCCEECHHHH		44.827961021
544UbiquitinationSQLEPGEKAELLEAF
HHCCCCHHHHHHHHH		53.74-
552UbiquitinationAELLEAFKESCGHLG
HHHHHHHHHHCCCHH		56.62-
567PhosphorylationDCYSRLDSQHSHLTL
HHHHHHHHCCCCCCC		34.0920873877
570PhosphorylationSRLDSQHSHLTLPYY
HHHHHCCCCCCCCCH		16.7420873877
573PhosphorylationDSQHSHLTLPYYKMS
HHCCCCCCCCCHHCC		21.9120873877
576PhosphorylationHSHLTLPYYKMSGLS
CCCCCCCCHHCCCCC		20.8720873877
577PhosphorylationSHLTLPYYKMSGLSM
CCCCCCCHHCCCCCH		9.7720873877
578UbiquitinationHLTLPYYKMSGLSMA
CCCCCCHHCCCCCHH		22.27-
601UbiquitinationTVEDGLQKYERGLIF
CHHHHHHHCHHCEEE		54.87-
635PhosphorylationAKVVQMFYVAEPKQV
HHHHHHHHHCCCCCC		8.0722210691
648PhosphorylationQVPHILCSPSMKNIN
CCCEEEECCCCCCCC		19.3025159151
650PhosphorylationPHILCSPSMKNINPL
CEEEECCCCCCCCHH		26.5427732954
686UbiquitinationTKAAVALKMGDLDMH
HHHHHHHHHCCHHHC		30.97-
721UbiquitinationRLLIQQRKGQIVPTE
HHHHHHHCCCCCCCH		51.32-
750UbiquitinationASVLGLQKNNKIGIE
HHHHCCHHCCCCCHH		68.48-
753UbiquitinationLGLQKNNKIGIEEAD
HCCHHCCCCCHHHHH		52.26-
818PhosphorylationSKRQPPDTTPLRTSE
HCCCCCCCCCCCCHH		35.7723532336
819PhosphorylationKRQPPDTTPLRTSED
CCCCCCCCCCCCHHH		27.9224043423
902UbiquitinationVLCRTRLKEYEQCID
HHHHHHCHHHHHHHH		55.76-
928UbiquitinationPYANHELKEENRTLW
CCCCCCHHHHHHHHH		61.06-
938UbiquitinationNRTLWWKKLLPELCQ
HHHHHHHHHHHHHHH		41.35-
957PhosphorylationGGEKYQLYLSSLKET
CCCHHHEHHHHHHHH		6.7622817900
959PhosphorylationEKYQLYLSSLKETLS
CHHHEHHHHHHHHHH		21.7724719451
960PhosphorylationKYQLYLSSLKETLSI
HHHEHHHHHHHHHHE		40.6522817900
964PhosphorylationYLSSLKETLSIVAVE
HHHHHHHHHHEEEEE		24.9924961811
966PhosphorylationSSLKETLSIVAVELE
HHHHHHHHEEEEEEE		23.5724961811
996PhosphorylationFFLPYLLYCSRKKPL
EHHHHHHHHCCCCCC		5.9317053785
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HPS3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HPS3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HPS3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HPS3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614072Hermansky-Pudlak syndrome 3 (HPS3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HPS3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-957 AND SER-960, ANDMASS SPECTROMETRY.
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-996, AND MASSSPECTROMETRY.

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