KLDC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLDC3_HUMAN
• UniProt AC: Q9BQ90
• Protein Name: Kelch domain-containing protein 3
• Gene Name: KLHDC3
• Organism: Homo sapiens (Human).
• Sequence Length: 382
• Subcellular Localization: Cytoplasm. Also found in meiotic chromatin..
• Protein Description: May be involved in meiotic recombination process..
• Protein Sequence: MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MLRWTVHLEGGP ---CCCEEEEECCCC	7.51	17322306
57	Phosphorylation	NAVSLRWTKLPPVKS ECCCCCCCCCCCCCH	19.10	23898821
63	Ubiquitination	WTKLPPVKSAIRGQA CCCCCCCCHHHCCCC	39.69	29901268
67	Methylation	PPVKSAIRGQAPVVP CCCCHHHCCCCCCCC	30.78	115481341
114	Ubiquitination	AFDVNTHKWFTPRVS EEECCCCEEECCCCC	41.80	-
286	Sumoylation	KKIEPKGKGPCPRRR EECCCCCCCCCCCCC	66.85	-
339	Ubiquitination	LDFSPSLKTLCKLAV EECCHHHHHHHHHHH	43.73	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLDC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLDC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLDC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL2_HUMAN	CUL2	physical	18187417
ELOB_HUMAN	TCEB2	physical	18187417
ELOC_HUMAN	TCEB1	physical	18187417
CUL5_HUMAN	CUL5	physical	18187417
CSN2_HUMAN	COPS2	physical	26186194
RP25L_HUMAN	RPP25L	physical	26186194
CUL2_HUMAN	CUL2	physical	26186194
CSN6_HUMAN	COPS6	physical	26186194
BRAP_HUMAN	BRAP	physical	26186194
DPYL5_HUMAN	DPYSL5	physical	26186194
NEDD8_HUMAN	NEDD8	physical	26186194
UBP10_HUMAN	USP10	physical	26186194
NUDC3_HUMAN	NUDCD3	physical	26186194
TSYL4_HUMAN	TSPYL4	physical	26186194
DPYL2_HUMAN	DPYSL2	physical	26186194
FOXK1_HUMAN	FOXK1	physical	26186194
MOCS1_HUMAN	MOCS1	physical	26186194
CC033_HUMAN	C3orf33	physical	26186194
SYMPK_HUMAN	SYMPK	physical	26186194
DIDO1_HUMAN	DIDO1	physical	26186194
POP7_HUMAN	POP7	physical	26186194
BRAP_HUMAN	BRAP	physical	28514442
LUZP1_HUMAN	LUZP1	physical	28514442
KS6A4_HUMAN	RPS6KA4	physical	28514442
CUL2_HUMAN	CUL2	physical	28514442
RP25L_HUMAN	RPP25L	physical	28514442
CLAP2_HUMAN	CLASP2	physical	28514442
AFAD_HUMAN	MLLT4	physical	28514442
SYMPK_HUMAN	SYMPK	physical	28514442
HMCES_HUMAN	HMCES	physical	28514442
4ET_HUMAN	EIF4ENIF1	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
MOCS1_HUMAN	MOCS1	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
POP7_HUMAN	POP7	physical	28514442
DAPK3_HUMAN	DAPK3	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
PI51A_HUMAN	PIP5K1A	physical	28514442
CSN2_HUMAN	COPS2	physical	28514442
TSYL4_HUMAN	TSPYL4	physical	28514442
TBL1X_HUMAN	TBL1X	physical	28514442
DPYL5_HUMAN	DPYSL5	physical	28514442
NUDC3_HUMAN	NUDCD3	physical	28514442
CSN6_HUMAN	COPS6	physical	28514442
DPYL2_HUMAN	DPYSL2	physical	28514442
DPYL4_HUMAN	DPYSL4	physical	28514442
ELOC_HUMAN	TCEB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.