SENP5_HUMAN - dbPTM
SENP5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SENP5_HUMAN
UniProt AC Q96HI0
Protein Name Sentrin-specific protease 5
Gene Name SENP5
Organism Homo sapiens (Human).
Sequence Length 755
Subcellular Localization Nucleus, nucleolus .
Protein Description Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division..
Protein Sequence MKKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKLGRPVTWNRQLRHFQGRKKALQIQKTWIKDEPLCAKTKFNVATQNVSTLSSKVKRKDAKHFISSSKTLLRLQAEKLLSSAKNSDHEYCREKNLLKAVTDFPSNSALGQANGHRPRTDPQPSDFPMKFNGESQSPGESGTIVVTLNNHKRKGFCYGCCQGPEHHRNGGPLIPKKFQLNQHRRIKLSPLMMYEKLSMIRFRYRILRSQHFRTKSKVCKLRKAQRSWVQKVTGDHQETRRENGEGGSCSPFPSPEPKDPSCRHQPYFPDMDSSAVVKGTNSHVPDCHTKGSSFLGKELSLDEAFPDQQNGSATNAWDQSSCSSPKWECTELIHDIPLPEHRSNTMFISETEREIMTLGQENQTSSVSDDRVKLSVSGADTSVSSVDGPVSQKAVQNENSYQMEEDGSLKQSILSSELLDHPYCKSPLEAPLVCSGLKLENQVGGGKNSQKASPVDDEQLSVCLSGFLDEVMKKYGSLVPLSEKEVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSNRIISFYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYKELCECRLMD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Acetylation-----MKKQRKILWR
-----CCHHHHHHHH		54.7869459
6Acetylation--MKKQRKILWRKGI
--CCHHHHHHHHCCC		39.3969463
11AcetylationQRKILWRKGIHLAFS
HHHHHHHCCCHHEEE		51.1169467
18PhosphorylationKGIHLAFSEKWNTGF
CCCHHEEECCCCCCC		32.4324719451
62UbiquitinationRHFQGRKKALQIQKT
HHHCCHHHHHHHHCC		53.63-
72UbiquitinationQIQKTWIKDEPLCAK
HHHCCCCCCCCCCCC		47.83-
79AcetylationKDEPLCAKTKFNVAT
CCCCCCCCCCCEEEC		51.7825953088
90PhosphorylationNVATQNVSTLSSKVK
EEECCCHHHHCHHCC		31.0524173317
91PhosphorylationVATQNVSTLSSKVKR
EECCCHHHHCHHCCH		26.7824173317
93PhosphorylationTQNVSTLSSKVKRKD
CCCHHHHCHHCCHHH		28.3528555341
94PhosphorylationQNVSTLSSKVKRKDA
CCHHHHCHHCCHHHH		44.5828555341
95AcetylationNVSTLSSKVKRKDAK
CHHHHCHHCCHHHHH		48.6925953088
106PhosphorylationKDAKHFISSSKTLLR
HHHHHHHHCCHHHHH		27.84-
107PhosphorylationDAKHFISSSKTLLRL
HHHHHHHCCHHHHHH		30.91-
109UbiquitinationKHFISSSKTLLRLQA
HHHHHCCHHHHHHHH		45.18-
159PhosphorylationANGHRPRTDPQPSDF
CCCCCCCCCCCCCCC		55.5020068231
164PhosphorylationPRTDPQPSDFPMKFN
CCCCCCCCCCCCCCC		46.7920068231
174PhosphorylationPMKFNGESQSPGESG
CCCCCCCCCCCCCCC		37.0425627689
176PhosphorylationKFNGESQSPGESGTI
CCCCCCCCCCCCCEE		44.1222199227
180PhosphorylationESQSPGESGTIVVTL
CCCCCCCCCEEEEEE		47.3422199227
182PhosphorylationQSPGESGTIVVTLNN
CCCCCCCEEEEEECC		21.6322199227
216UbiquitinationGGPLIPKKFQLNQHR
CCCCCCCCCCCCCCC		32.75-
228PhosphorylationQHRRIKLSPLMMYEK
CCCCCCCCHHHHHHH		15.8122199227
243PhosphorylationLSMIRFRYRILRSQH
HHHHHHHHHHHHCCC		10.17-
270UbiquitinationAQRSWVQKVTGDHQE
HHHHHHHHHHCCCHH		31.95-
270UbiquitinationAQRSWVQKVTGDHQE
HHHHHHHHHHCCCHH		31.95-
287PhosphorylationRENGEGGSCSPFPSP
HHCCCCCCCCCCCCC		23.4423663014
289PhosphorylationNGEGGSCSPFPSPEP
CCCCCCCCCCCCCCC		31.1323663014
293PhosphorylationGSCSPFPSPEPKDPS
CCCCCCCCCCCCCCC		42.1323927012
306PhosphorylationPSCRHQPYFPDMDSS
CCCCCCCCCCCCCCC		22.6029759185
312PhosphorylationPYFPDMDSSAVVKGT
CCCCCCCCCCEEECC		17.3529759185
313PhosphorylationYFPDMDSSAVVKGTN
CCCCCCCCCEEECCC		22.3328555341
332PhosphorylationDCHTKGSSFLGKELS
CCCCCCCCCCCCCCC		32.91-
339PhosphorylationSFLGKELSLDEAFPD
CCCCCCCCCCCCCCC		34.5627251275
351PhosphorylationFPDQQNGSATNAWDQ
CCCCCCCCCCCCCCC		39.2027251275
353PhosphorylationDQQNGSATNAWDQSS
CCCCCCCCCCCCCHH		27.4522210691
359PhosphorylationATNAWDQSSCSSPKW
CCCCCCCHHCCCCCE		30.7326074081
360PhosphorylationTNAWDQSSCSSPKWE
CCCCCCHHCCCCCEE		16.6325159151
362PhosphorylationAWDQSSCSSPKWECT
CCCCHHCCCCCEEEE		52.1826074081
363PhosphorylationWDQSSCSSPKWECTE
CCCHHCCCCCEEEEH		34.5225159151
369PhosphorylationSSPKWECTELIHDIP
CCCCEEEEHHHHCCC		23.4726074081
414PhosphorylationSDDRVKLSVSGADTS
CCCCEEEEECCCCCC		14.4428450419
416PhosphorylationDRVKLSVSGADTSVS
CCEEEEECCCCCCCC		25.5328450419
420PhosphorylationLSVSGADTSVSSVDG
EEECCCCCCCCCCCC		30.4128450419
421PhosphorylationSVSGADTSVSSVDGP
EECCCCCCCCCCCCC		22.1328450419
423PhosphorylationSGADTSVSSVDGPVS
CCCCCCCCCCCCCCC		25.1428450419
424PhosphorylationGADTSVSSVDGPVSQ
CCCCCCCCCCCCCCH		23.2828450419
439PhosphorylationKAVQNENSYQMEEDG
HHHCCCCCCCCCCCC		15.5728985074
449UbiquitinationMEEDGSLKQSILSSE
CCCCCCCCHHHHCHH		43.63-
454PhosphorylationSLKQSILSSELLDHP
CCCHHHHCHHHHCCC		21.7928122231
455PhosphorylationLKQSILSSELLDHPY
CCHHHHCHHHHCCCC		28.9028122231
462PhosphorylationSELLDHPYCKSPLEA
HHHHCCCCCCCCCCC		14.7526074081
465PhosphorylationLDHPYCKSPLEAPLV
HCCCCCCCCCCCCEE		31.0230266825
474PhosphorylationLEAPLVCSGLKLENQ
CCCCEEECCCEEECC		39.4128122231
477UbiquitinationPLVCSGLKLENQVGG
CEEECCCEEECCCCC		58.23-
486UbiquitinationENQVGGGKNSQKASP
ECCCCCCCCCCCCCC		57.61-
513UbiquitinationFLDEVMKKYGSLVPL
HHHHHHHHHCCCCCC		36.43-
513UbiquitinationFLDEVMKKYGSLVPL
HHHHHHHHHCCCCCC		36.43-
523UbiquitinationSLVPLSEKEVLGRLK
CCCCCCHHHHHHHHH		50.15-
523UbiquitinationSLVPLSEKEVLGRLK
CCCCCCHHHHHHHHH		50.15-
530UbiquitinationKEVLGRLKDVFNEDF
HHHHHHHHHHCCCCC		50.95-
530UbiquitinationKEVLGRLKDVFNEDF
HHHHHHHHHHCCCCC		50.95-
651PhosphorylationEVHWSLITVTLSNRI
EEEEEEEEEEECCCE		16.84-
679PhosphorylationCVENIRKYLLTEARE
HHHHHHHHHHHHHHH		9.33-
682PhosphorylationNIRKYLLTEAREKNR
HHHHHHHHHHHHHCC		25.63-
687UbiquitinationLLTEAREKNRPEFLQ
HHHHHHHHCCHHHHH		53.34-
700UbiquitinationLQGWQTAVTKCIPQQ
HHHHHHHHHHHCCCC		6.29-
746UbiquitinationRVRKRIYKELCECRL
HHHHHHHHHHHHHHC		41.67-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SENP5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SENP5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SENP5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUMO3_HUMANSUMO3physical
16608850
SUMO2_HUMANSUMO2physical
16608850
RBGP1_HUMANRABGAP1physical
16608850
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SENP5_HUMAN

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Related Literatures of Post-Translational Modification

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