dbPTM

SRGP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRGP1_HUMAN
UniProt AC	Q7Z6B7
Protein Name	SLIT-ROBO Rho GTPase-activating protein 1
Gene Name	SRGAP1
Organism	Homo sapiens (Human).
Sequence Length	1085
Subcellular Localization
Protein Description	GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42..
Protein Sequence	MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTDKSCTM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	DKEIIAEYESQVKEI CHHHHHHHHHHHHHH	16.32	19664994
22	Ubiquitination	AEYESQVKEIRAQLV HHHHHHHHHHHHHHH	39.52	29967540
69	Ubiquitination	EYSRNLEKLAERFMA HHHHHHHHHHHHHHH	57.05	-
196	Phosphorylation	EEKQIGRSGDPVFHI HHHHHCCCCCCCEEC	42.19	25159151
220	Acetylation	SSVKKIEKMKEKRQA HHHHHHHHHHHHHHH	59.76	-
222	Acetylation	VKKIEKMKEKRQAKY HHHHHHHHHHHHHHC	71.76	-
224	Acetylation	KIEKMKEKRQAKYSE HHHHHHHHHHHHCCH	44.27	-
235	Acetylation	KYSENKLKSIKARNE HCCHHHHHHHHHHCC	52.31	7306897
359	Phosphorylation	QAELMLRYQQLQSRL HHHHHHHHHHHHHHH	9.17	25884760
383	Phosphorylation	VKKTTEATLQTIQDM HHHHHHHHHHHHHHC	17.11	23879269
392	Phosphorylation	QTIQDMVTIEDYDVS HHHHHCCCCCCCCHH	16.41	27251275
396	Phosphorylation	DMVTIEDYDVSECFQ HCCCCCCCCHHHHHH	12.88	27251275
399	Phosphorylation	TIEDYDVSECFQHSR CCCCCCHHHHHHCCC	26.25	27251275
405	Phosphorylation	VSECFQHSRSTESVK HHHHHHCCCCCHHHH	19.69	27251275
407	Phosphorylation	ECFQHSRSTESVKST HHHHCCCCCHHHHHH	39.27	17081983
408	Phosphorylation	CFQHSRSTESVKSTV HHHCCCCCHHHHHHH	31.04	17081983
410	Phosphorylation	QHSRSTESVKSTVSE HCCCCCHHHHHHHCH	34.63	25849741
412	Ubiquitination	SRSTESVKSTVSETY CCCCHHHHHHHCHHH	50.08	29967540
413	Phosphorylation	RSTESVKSTVSETYL CCCHHHHHHHCHHHH	31.70	25159151
414	Phosphorylation	STESVKSTVSETYLS CCHHHHHHHCHHHHC	23.49	23927012
416	Phosphorylation	ESVKSTVSETYLSKP HHHHHHHCHHHHCCH	25.06	25159151
418	Phosphorylation	VKSTVSETYLSKPSI HHHHHCHHHHCCHHH	23.43	23663014
419	Phosphorylation	KSTVSETYLSKPSIA HHHHCHHHHCCHHHH	12.62	23927012
421	Phosphorylation	TVSETYLSKPSIAKR HHCHHHHCCHHHHHH	31.91	23927012
424	Phosphorylation	ETYLSKPSIAKRRAN HHHHCCHHHHHHHCC	38.63	27251275
446	Phosphorylation	YFMKLREYLEGSNLI HHHHHHHHHCCCCHH	12.01	-
454	Phosphorylation	LEGSNLITKLQAKHD HCCCCHHHHHHHHHH	28.94	-
455	Ubiquitination	EGSNLITKLQAKHDL CCCCHHHHHHHHHHH	31.44	29967540
459	Malonylation	LITKLQAKHDLLQRT HHHHHHHHHHHHHHH	25.37	26320211
459	Ubiquitination	LITKLQAKHDLLQRT HHHHHHHHHHHHHHH	25.37	33845483
475	Phosphorylation	GEGHRAEYMTTRPPN CCCCCCEECCCCCCC	9.97	27642862
493	Phosphorylation	KPQKHRKSRPRSQYN CCCCCCCCCCHHHHC	47.69	24706070
497	Phosphorylation	HRKSRPRSQYNTKLF CCCCCCHHHHCCCCC	39.43	24706070
510	Phosphorylation	LFNGDLETFVKDSGQ CCCCCHHHHCCCCCC	40.81	27251275
515	Phosphorylation	LETFVKDSGQVIPLI HHHHCCCCCCCHHHH	25.96	26503514
525	Phosphorylation	VIPLIVESCIRFINL CHHHHHHHHHHHHHH	12.16	26503514
546	Phosphorylation	GIFRVSGSQVEVNDI EEEEEECCEEEHHHH	24.44	24505115
622	O-linked_Glycosylation	HIRKLLLTLPRSVLI HHHHHHHHCCHHHHH	34.38	30059200
622	Phosphorylation	HIRKLLLTLPRSVLI HHHHHHHHCCHHHHH	34.38	24719451
705	Phosphorylation	KELDGPVYEKCMAGD HHCCCCHHHHHCCCC	16.89	25159151
714	Phosphorylation	KCMAGDDYCDSPYSE HHCCCCCCCCCCCCC	11.69	22817900
719	Phosphorylation	DDYCDSPYSEHGTLE CCCCCCCCCCCCCHH	30.55	22817900
738	Phosphorylation	DAGTEPHTSEDECEP CCCCCCCCCCCCCCC	44.52	22210691
739	Phosphorylation	AGTEPHTSEDECEPI CCCCCCCCCCCCCCH	39.76	22210691
754	Phosphorylation	EAIAKFDYVGRSARE HHHHCCCCCCCCHHH	14.13	29759185
758	Phosphorylation	KFDYVGRSARELSFK CCCCCCCCHHHHCCC	26.25	29759185
763	Phosphorylation	GRSARELSFKKGASL CCCHHHHCCCCCCEE	30.21	24719451
766	Malonylation	ARELSFKKGASLLLY HHHHCCCCCCEEEEE	58.67	32601280
769	Phosphorylation	LSFKKGASLLLYHRA HCCCCCCEEEEEECC	28.37	28857561
773	Phosphorylation	KGASLLLYHRASEDW CCCEEEEEECCCCCH	6.82	24719451
777	Phosphorylation	LLLYHRASEDWWEGR EEEEECCCCCHHCCC	35.72	25332170
816	Phosphorylation	TLSQKADSEASSGPV HHHHHCCCCHHCCCC	39.66	21815630
819	Phosphorylation	QKADSEASSGPVTED HHCCCCHHCCCCCCC	31.60	28985074
820	Phosphorylation	KADSEASSGPVTEDK HCCCCHHCCCCCCCC	54.91	25159151
824	Phosphorylation	EASSGPVTEDKSSSK CHHCCCCCCCCCCCC	41.42	29514088
828	Phosphorylation	GPVTEDKSSSKDMNS CCCCCCCCCCCCCCC	52.76	25627689
829	Phosphorylation	PVTEDKSSSKDMNSP CCCCCCCCCCCCCCC	47.34	25627689
835	Phosphorylation	SSSKDMNSPTDRHPD CCCCCCCCCCCCCCC	23.65	30266825
837	Phosphorylation	SKDMNSPTDRHPDGY CCCCCCCCCCCCCCH	45.55	30266825
844	Phosphorylation	TDRHPDGYLARQRKR CCCCCCCHHHHHHHC	12.45	30266825
864	Phosphorylation	PVRRPGRTSDGHCPL CCCCCCCCCCCCCCC	36.76	28857561
865	Phosphorylation	VRRPGRTSDGHCPLH CCCCCCCCCCCCCCC	39.99	28857561
878	Phosphorylation	LHPPHALSNSSVDLG CCCCCCCCCCCCCCC	35.13	27251275
880	Phosphorylation	PPHALSNSSVDLGSP CCCCCCCCCCCCCCC	28.50	27794612
881	Phosphorylation	PHALSNSSVDLGSPS CCCCCCCCCCCCCCH	24.73	29116813
886	Phosphorylation	NSSVDLGSPSLASHP CCCCCCCCCHHHCCC	20.72	27422710
888	Phosphorylation	SVDLGSPSLASHPRG CCCCCCCHHHCCCHH	37.96	27794612
891	Phosphorylation	LGSPSLASHPRGLLQ CCCCHHHCCCHHHHH	39.04	27794612
900	Methylation	PRGLLQNRGLNNDSP CHHHHHCCCCCCCCH	37.71	-
906	Phosphorylation	NRGLNNDSPERRRRP CCCCCCCCHHHHCCC	30.68	29255136
915	Phosphorylation	ERRRRPGHGSLTNIS HHHCCCCCCCCCCCC	25.92	32142685
917	Phosphorylation	RRRPGHGSLTNISRH HCCCCCCCCCCCCCC	26.75	28731282
919	Phosphorylation	RPGHGSLTNISRHDS CCCCCCCCCCCCCCC	32.00	28152594
922	Phosphorylation	HGSLTNISRHDSLKK CCCCCCCCCCCCCCC	26.15	28152594
926	Phosphorylation	TNISRHDSLKKIDSP CCCCCCCCCCCCCCC	35.64	29214152
932	Phosphorylation	DSLKKIDSPPIRRST CCCCCCCCCCCCCCC	35.73	30266825
938	Phosphorylation	DSPPIRRSTSSGQYT CCCCCCCCCCCCCCC	23.85	29978859
939	Phosphorylation	SPPIRRSTSSGQYTG CCCCCCCCCCCCCCC	25.71	29978859
940	Phosphorylation	PPIRRSTSSGQYTGF CCCCCCCCCCCCCCC	33.45	25849741
941	Phosphorylation	PIRRSTSSGQYTGFN CCCCCCCCCCCCCCC	29.97	29978859
944	Phosphorylation	RSTSSGQYTGFNDHK CCCCCCCCCCCCCCC	16.62	29978859
945	Phosphorylation	STSSGQYTGFNDHKP CCCCCCCCCCCCCCC	27.66	29978859
983	Ubiquitination	LERQSTAKHAPDVVL HHHHHHHHHCCCHHH	40.15	29967540
987	Phosphorylation	STAKHAPDVVLDTLE HHHHHCCCHHHHHHH	43.89	32142685
992	Phosphorylation	APDVVLDTLEQVKNS CCCHHHHHHHHHHCC	28.21	29496963
999	Phosphorylation	TLEQVKNSPTPATST HHHHHHCCCCCCCCC	25.16	30278072
1001	Phosphorylation	EQVKNSPTPATSTES HHHHCCCCCCCCCCC	25.94	22167270
1004	Phosphorylation	KNSPTPATSTESLSP HCCCCCCCCCCCCCC	37.07	22167270
1005	O-linked_Glycosylation	NSPTPATSTESLSPL CCCCCCCCCCCCCCH	32.08	30059200
1005	Phosphorylation	NSPTPATSTESLSPL CCCCCCCCCCCCCCH	32.08	22167270
1006	Phosphorylation	SPTPATSTESLSPLH CCCCCCCCCCCCCHH	25.82	22167270
1008	Phosphorylation	TPATSTESLSPLHNV CCCCCCCCCCCHHCH	33.95	22167270
1009	Phosphorylation	PATSTESLSPLHNVA CCCCCCCCCCHHCHH	5.07	33259812
1010	Phosphorylation	ATSTESLSPLHNVAL CCCCCCCCCHHCHHH	34.39	25159151
1027	Phosphorylation	SEPQIRRSTSSSSDT CCCCHHHCCCCCCCC	23.85	23927012
1028	Phosphorylation	EPQIRRSTSSSSDTM CCCHHHCCCCCCCCH	30.71	23927012
1029	Phosphorylation	PQIRRSTSSSSDTMS CCHHHCCCCCCCCHH	29.48	23927012
1030	Phosphorylation	QIRRSTSSSSDTMST CHHHCCCCCCCCHHH	33.67	23927012
1031	Phosphorylation	IRRSTSSSSDTMSTF HHHCCCCCCCCHHHC	31.81	23927012
1032	Phosphorylation	RRSTSSSSDTMSTFK HHCCCCCCCCHHHCC	38.76	23927012
1034	Phosphorylation	STSSSSDTMSTFKPM CCCCCCCCHHHCCCC	18.24	23927012
1036	Phosphorylation	SSSSDTMSTFKPMVA CCCCCCHHHCCCCCC	32.55	30576142
1037	Phosphorylation	SSSDTMSTFKPMVAP CCCCCHHHCCCCCCC	25.51	30576142
1082	Phosphorylation	PQGPTDKSCTM---- CCCCCCCCCCC----	20.03	24719451
1084	Phosphorylation	GPTDKSCTM------ CCCCCCCCC------	32.76	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRGP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRGP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRGP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RHOA_HUMAN	RHOA	physical	20856855

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRGP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-999; THR-1001; THR-1004;SER-1008; SER-1010; SER-1029 AND SER-1032, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1005 AND SER-1010, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-906 AND SER-917, ANDMASS SPECTROMETRY.	17081983 [Abstract]