SAMN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAMN1_HUMAN
• UniProt AC: Q9NSI8
• Protein Name: SAM domain-containing protein SAMSN-1
• Gene Name: SAMSN1
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Nucleus . Cytoplasm. Cell projection, ruffle. Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity)..
• Protein Description: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity)..
• Protein Sequence: MLKRKPSNVSEKEKHQKPKRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKANRRSNSKKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNSDNGKEDLESENLSDMVHKIIITEPSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLKRKPSNVSEKEK -CCCCCCCCCCHHHH	53.55	26657352
10	Phosphorylation	KRKPSNVSEKEKHQK CCCCCCCCHHHHCCC	47.39	26074081
21	Phosphorylation	KHQKPKRSSSFGNFD HCCCCCCCCCCCCHH	36.14	23401153
22	Phosphorylation	HQKPKRSSSFGNFDR CCCCCCCCCCCCHHH	33.45	23401153
23	Phosphorylation	QKPKRSSSFGNFDRF CCCCCCCCCCCHHHH	38.12	23401153
34	Phosphorylation	FDRFRNNSLSKPDDS HHHHCCCCCCCCCCC	37.25	23401153
36	Phosphorylation	RFRNNSLSKPDDSTE HHCCCCCCCCCCCCC	41.80	22115753
41	Phosphorylation	SLSKPDDSTEAHEGD CCCCCCCCCCCCCCC	35.21	29978859
42	Phosphorylation	LSKPDDSTEAHEGDP CCCCCCCCCCCCCCC	44.16	29978859
50	Phosphorylation	EAHEGDPTNGSGEQS CCCCCCCCCCCCCCC	57.88	26434776
53	Phosphorylation	EGDPTNGSGEQSKTS CCCCCCCCCCCCCCC	41.02	26434776
59	Phosphorylation	GSGEQSKTSNNGGGL CCCCCCCCCCCCCCH	41.77	22468782
68	Acetylation	NNGGGLGKKMRAISW CCCCCHHHHHHHHHH	48.73	30592111
69	Acetylation	NGGGLGKKMRAISWT CCCCHHHHHHHHHHH	31.64	30592117
74	Phosphorylation	GKKMRAISWTMKKKV HHHHHHHHHHHHHHH	18.60	26434776
76	Phosphorylation	KMRAISWTMKKKVGK HHHHHHHHHHHHHCH	16.60	23917254
85	Phosphorylation	KKKVGKKYIKALSEE HHHHCHHHHHHHHHC	15.90	28111955
90	Phosphorylation	KKYIKALSEEKDEED HHHHHHHHHCCCCCC	48.87	23401153
102	Phosphorylation	EEDGENAHPYRNSDP CCCCCCCCCCCCCCC	31.35	27251275
104	Phosphorylation	DGENAHPYRNSDPVI CCCCCCCCCCCCCCC	16.74	26657352
107	Phosphorylation	NAHPYRNSDPVIGTH CCCCCCCCCCCCCCC	34.00	23401153
113	Phosphorylation	NSDPVIGTHTEKVSL CCCCCCCCCCCEEEE	17.94	30108239
115	Phosphorylation	DPVIGTHTEKVSLKA CCCCCCCCCEEEEEC	37.02	30108239
119	Phosphorylation	GTHTEKVSLKASDSM CCCCCEEEEECCCCC	34.91	23401153
123	Phosphorylation	EKVSLKASDSMDSLY CEEEEECCCCCCCCC	28.73	23401153
125	Phosphorylation	VSLKASDSMDSLYSG EEEECCCCCCCCCCC	23.22	23911959
128	Phosphorylation	KASDSMDSLYSGQSS ECCCCCCCCCCCCCC	22.14	30576142
130	Phosphorylation	SDSMDSLYSGQSSSS CCCCCCCCCCCCCCC	18.08	28450419
131	Phosphorylation	DSMDSLYSGQSSSSG CCCCCCCCCCCCCCC	35.33	28450419
134	Phosphorylation	DSLYSGQSSSSGITS CCCCCCCCCCCCCEE	35.40	28450419
135	Phosphorylation	SLYSGQSSSSGITSC CCCCCCCCCCCCEEC	22.19	30108239
136	Phosphorylation	LYSGQSSSSGITSCS CCCCCCCCCCCEECC	37.52	30108239
137	Phosphorylation	YSGQSSSSGITSCSD CCCCCCCCCCEECCC	35.84	30108239
140	Phosphorylation	QSSSSGITSCSDGTS CCCCCCCEECCCCCC	27.49	23186163
141	Phosphorylation	SSSSGITSCSDGTSN CCCCCCEECCCCCCC	15.09	23898821
142	Phosphorylation	SSSGITSCSDGTSNR CCCCCEECCCCCCCC	3.00	27251275
143	Phosphorylation	SSGITSCSDGTSNRD CCCCEECCCCCCCCC	38.55	23898821
146	Phosphorylation	ITSCSDGTSNRDSFR CEECCCCCCCCCCEE	28.02	23898821
147	Phosphorylation	TSCSDGTSNRDSFRL EECCCCCCCCCCEEC	35.08	23898821
151	Phosphorylation	DGTSNRDSFRLDDDG CCCCCCCCEECCCCC	14.72	23898821
158	Phosphorylation	SFRLDDDGPYSGPFC CEECCCCCCCCCCCC	30.00	27251275
160	Phosphorylation	RLDDDGPYSGPFCGR ECCCCCCCCCCCCCC	31.61	29978859
161	Phosphorylation	LDDDGPYSGPFCGRA CCCCCCCCCCCCCCE	43.02	29978859
172	Phosphorylation	CGRARVHTDFTPSPY CCCEEEECCCCCCCC	29.92	28152594
175	Phosphorylation	ARVHTDFTPSPYDTD EEEECCCCCCCCCCC	26.18	28152594
177	Phosphorylation	VHTDFTPSPYDTDSL EECCCCCCCCCCCCC	32.79	28152594
179	Phosphorylation	TDFTPSPYDTDSLKI CCCCCCCCCCCCCEE	35.49	28152594
181	Phosphorylation	FTPSPYDTDSLKIKK CCCCCCCCCCCEECC	22.96	28152594
183	Phosphorylation	PSPYDTDSLKIKKGD CCCCCCCCCEECCCC	33.38	28152594
193	Phosphorylation	IKKGDIIDIICKTPM ECCCCEEEEEECCCC	25.24	27251275
223	Phosphorylation	FIYVDVISEEEAAPK EEEEEECCHHHHCCH	38.51	27251275
297	Phosphorylation	DDRRRLLSAAENFLE HHHHHHHHHHHHHHH	29.99	-
325	Phosphorylation	LSLSSDISLNKSQLD CCCCCCCCCCHHHHC	30.77	-
329	Phosphorylation	SDISLNKSQLDDCPR CCCCCCHHHHCCCCC	34.60	29485707
338	Phosphorylation	LDDCPRDSGCYISSG HCCCCCCCCCEEECC	31.85	28450419
341	Phosphorylation	CPRDSGCYISSGNSD CCCCCCCEEECCCCC	13.83	28450419
343	Phosphorylation	RDSGCYISSGNSDNG CCCCCEEECCCCCCC	13.01	22115753
344	Phosphorylation	DSGCYISSGNSDNGK CCCCEEECCCCCCCC	32.22	22115753
347	Phosphorylation	CYISSGNSDNGKEDL CEEECCCCCCCCCHH	35.66	23401153
356	Phosphorylation	NGKEDLESENLSDMV CCCCHHHHCCHHHHC	38.80	26657352
360	Phosphorylation	DLESENLSDMVHKII HHHHCCHHHHCEEEE	34.93	26074081
372	Phosphorylation	KIIITEPSD------ EEEECCCCC------	50.12	30108239
412	Phosphorylation	---------------------------------------------- ----------------------------------------------		27251275
415	Phosphorylation	------------------------------------------------- -------------------------------------------------		27251275
424	Phosphorylation	---------------------------------------------------------- ----------------------------------------------------------		27251275
440	Phosphorylation	-------------------------------------------------------------------------- --------------------------------------------------------------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAMN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAMN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAMN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433G_HUMAN	YWHAG	physical	20478393
SAP30_HUMAN	SAP30	physical	20478393
HDAC1_HUMAN	HDAC1	physical	20478393
SAP30_MOUSE	Sap30	physical	20478393

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.