MPP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPP4_HUMAN
• UniProt AC: Q96JB8
• Protein Name: MAGUK p55 subfamily member 4
• Gene Name: MPP4
• Organism: Homo sapiens (Human).
• Sequence Length: 637
• Subcellular Localization: Cytoplasm . Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ).
• Protein Description: May play a role in retinal photoreceptors development..
• Protein Sequence: MIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWISSDTESQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Acetylation	YDCLQEFKEKKLVPA HHHHHHHHHCCCCCC	68.80	7959429
101	Phosphorylation	VVELLRETPTSPEIQ HHHHHHCCCCCHHHH	25.98	28122231
103	Phosphorylation	ELLRETPTSPEIQEL HHHHCCCCCHHHHHH	65.42	28122231
104	Phosphorylation	LLRETPTSPEIQELR HHHCCCCCHHHHHHH	23.03	28122231
148	Phosphorylation	LPDNIPESEEAMRIV CCCCCCCCHHHHHHH	35.07	-
303 (in isoform 4)	Phosphorylation	-	34.16	26657352
304	Phosphorylation	TCAGLVPSNHLLKRK HHCCCCCCCHHHHHH	29.42	-
306 (in isoform 4)	Phosphorylation	-	36.56	26657352
436	O-linked_Glycosylation	LIVLMGPSGVGVNEL EEEEECCCCCCHHHH	40.14	23301498
462	Phosphorylation	FQSAVPHTTRTKKSY HHCCCCCCCCCCEEE	16.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPP4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MPP4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.