MACC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MACC1_HUMAN
• UniProt AC: Q6ZN28
• Protein Name: Metastasis-associated in colon cancer protein 1
• Gene Name: MACC1
• Organism: Homo sapiens (Human).
• Sequence Length: 852
• Subcellular Localization: Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors.
• Protein Description: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo..
• Protein Sequence: MLITERKHFRSGRIAQSMSEANLIDMEAGKLSKSCNITECQDPDLLHNWPDAFTLRGNNASKVANPFWNQLSASNPFLDDITQLRNNRKRNNISILKEDPFLFCREIENGNSFDSSGDELDVHQLLRQTSSRNSGRSKSVSELLDILDDTAHAHQSIHNSDQILLHDLEWLKNDREAYKMAWLSQRQLARSCLDLNTISQSPGWAQTQLAEVTIACKVNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPHMLNHDLSCTVSPLLEIMLGNLNTMEALLLEMKIGAEVRKDPFSQVMTEMVCLHSLGKEGPFKVLSNCYIYKDTIQVKLIDLSQVMYLVVAAQAKALPSPAATIWDYIHKTTSIGIYGPKYIHPSFTVVLTVCGHNYMPGQLTISDIKKGGKNISPVVFQLWGKQSFLLDKPQDLSISIFSCDPDFEVKTEGERKEIKQKQLEAGEVVHQQFLFSLVEHREMHLFDFCVQVEPPNGEPVAQFSITTPDPTPNLKRLSNLPGYLQKKEEIKSAPLSPKILVKYPTFQDKTLNFSNYGVTLKAVLRQSKIDYFLEYFKGDTIALLGEGKVKAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMFMSDSVFTTRNLLEQIVLPLKKLTYIYSVVLTLVSEKVYDWKVLADVLGYSHLSLEDFDQIQADKESEKVSYVIKKLKEDCHTERNTRKFLYELIVALLKMDCQELVARLIQEAAVLTSAVKLGKGWRELAEKLVRLTKQQMEAYEIPHRGNTGDVAVEMMWKPAYDFLYTWSAHYGNNYRDVLQDLQSALDRMKNPVTKHWRELTGVLILVNSLEVLRVTAFSTSEEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLITERKHFRS ----CCCCCCHHHCC	26.27	24719451
11	Phosphorylation	TERKHFRSGRIAQSM CCCHHHCCCCCCCCH	31.32	24719451
17	Phosphorylation	RSGRIAQSMSEANLI CCCCCCCCHHHHCCC	18.43	28857561
19	Phosphorylation	GRIAQSMSEANLIDM CCCCCCHHHHCCCCH	38.51	26657352
32	Phosphorylation	DMEAGKLSKSCNITE CHHCCHHCCCCCCCC	26.47	24719451
34	Phosphorylation	EAGKLSKSCNITECQ HCCHHCCCCCCCCCC	14.71	28857561
38	Phosphorylation	LSKSCNITECQDPDL HCCCCCCCCCCCHHH	19.40	27080861
54	Phosphorylation	HNWPDAFTLRGNNAS HCCCCCEEECCCCHH	19.78	24719451
72	Phosphorylation	NPFWNQLSASNPFLD CHHHHHHHCCCCCHH	21.64	26657352
74	Phosphorylation	FWNQLSASNPFLDDI HHHHHHCCCCCHHHH	41.48	25849741
82	Phosphorylation	NPFLDDITQLRNNRK CCCHHHHHHHHHCCC	28.66	22115753
94	Phosphorylation	NRKRNNISILKEDPF CCCCCCCCCCCCCCC	24.80	25056879
112	Phosphorylation	REIENGNSFDSSGDE EECCCCCCCCCCCCC	31.65	22617229
115	Phosphorylation	ENGNSFDSSGDELDV CCCCCCCCCCCCCCH	33.92	22617229
116	Phosphorylation	NGNSFDSSGDELDVH CCCCCCCCCCCCCHH	52.70	22617229
130	Phosphorylation	HQLLRQTSSRNSGRS HHHHHHHCCCCCCCC	20.97	-
131	Phosphorylation	QLLRQTSSRNSGRSK HHHHHHCCCCCCCCC	38.58	-
134	Phosphorylation	RQTSSRNSGRSKSVS HHHCCCCCCCCCCHH	34.18	-
137	Phosphorylation	SSRNSGRSKSVSELL CCCCCCCCCCHHHHH	32.57	-
178	Phosphorylation	LKNDREAYKMAWLSQ HHCCHHHHHHHHHHH	9.13	-
184	Phosphorylation	AYKMAWLSQRQLARS HHHHHHHHHHHHHHH	16.77	22617229
191	Phosphorylation	SQRQLARSCLDLNTI HHHHHHHHHCCCCCC	17.27	26657352
302	Phosphorylation	EVRKDPFSQVMTEMV HHHCCCHHHHHHHHH	27.53	24719451
306	Phosphorylation	DPFSQVMTEMVCLHS CCHHHHHHHHHHHHH	23.28	29759185
313	Phosphorylation	TEMVCLHSLGKEGPF HHHHHHHHCCCCCCE	26.35	30377224
332	Phosphorylation	NCYIYKDTIQVKLID CCEEECCEEEEEEEE	14.79	29396449
369	Phosphorylation	IWDYIHKTTSIGIYG HHHHHHHCCEEEEEC	16.18	26434776
370	Phosphorylation	WDYIHKTTSIGIYGP HHHHHHCCEEEEECC	24.13	26434776
371	Phosphorylation	DYIHKTTSIGIYGPK HHHHHCCEEEEECCC	24.85	26434776
375	Phosphorylation	KTTSIGIYGPKYIHP HCCEEEEECCCCCCC	23.35	26434776
413	Phosphorylation	KKGGKNISPVVFQLW HCCCCCCCCHHHHHH	22.49	28857561
515	Phosphorylation	TPNLKRLSNLPGYLQ CCCHHHHHCCCCHHH	40.11	28176443
520	Phosphorylation	RLSNLPGYLQKKEEI HHHCCCCHHHCHHHH	12.20	28176443
529	Phosphorylation	QKKEEIKSAPLSPKI HCHHHHHCCCCCCCE	40.56	29396449
533	Phosphorylation	EIKSAPLSPKILVKY HHHCCCCCCCEEEEC	24.08	28188228
564	Phosphorylation	LKAVLRQSKIDYFLE HHHHHHHCCCHHHHH	25.74	24076635
568	Phosphorylation	LRQSKIDYFLEYFKG HHHCCCHHHHHHHCC	17.34	24076635
572	Phosphorylation	KIDYFLEYFKGDTIA CCHHHHHHHCCCEEE	16.85	24076635
645	Acetylation	QIVLPLKKLTYIYSV HHHHHHHHHHHHHHH	54.46	19821549
648	Phosphorylation	LPLKKLTYIYSVVLT HHHHHHHHHHHHHHH	14.32	25690035
650	Phosphorylation	LKKLTYIYSVVLTLV HHHHHHHHHHHHHHH	5.75	19835603
706	Phosphorylation	KLKEDCHTERNTRKF HHHHHHCCCHHHHHH	42.86	27470641
712	Ubiquitination	HTERNTRKFLYELIV CCCHHHHHHHHHHHH	37.37	33845483
803	Phosphorylation	SAHYGNNYRDVLQDL HCCCCCCHHHHHHHH	16.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MACC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MACC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MACC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MACC1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.