KALRN_HUMAN - dbPTM
KALRN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KALRN_HUMAN
UniProt AC O60229
Protein Name Kalirin {ECO:0000250|UniProtKB:P97924}
Gene Name KALRN {ECO:0000312|HGNC:HGNC:4814}
Organism Homo sapiens (Human).
Sequence Length 2985
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton . Associated with the cytoskeleton.
Protein Description Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity..
Protein Sequence MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59PhosphorylationKRGGPILTFPARSNH
CCCCCCCEEECCCCC		28.4324719451
86PhosphorylationTYLASVPSEDVCKRG
HHHHCCCCHHHHHCC		44.25-
95PhosphorylationDVCKRGFTVIIDMRG
HHHHCCCEEEEECCC		17.39-
103PhosphorylationVIIDMRGSKWDLIKP
EEEECCCCCHHHHHH		21.87-
1392-HydroxyisobutyrylationDNFWQKQKTNFGSSK
CCCCHHCCCCCCCCC		53.09-
154 (in isoform 6)Phosphorylation-6.0928270605
159 (in isoform 6)Phosphorylation-2.1225849741
163 (in isoform 6)Phosphorylation-12.4028270605
164 (in isoform 6)Phosphorylation-47.7928270605
165 (in isoform 6)Phosphorylation-19.2528270605
168 (in isoform 6)Phosphorylation-8.3728270605
223PhosphorylationFPVDVEGSRRLIDEH
CCCCCCCHHHHCHHH		10.75-
224 (in isoform 5)Phosphorylation-48.5628270605
229 (in isoform 5)Phosphorylation-41.6725849741
233 (in isoform 5)Phosphorylation-10.3728270605
234 (in isoform 5)Phosphorylation-40.5028270605
235 (in isoform 5)Phosphorylation-57.6228270605
238 (in isoform 5)Phosphorylation-5.5628270605
487PhosphorylationDVLQRPLSPGNSESL
HHHCCCCCCCCCCCC		33.1822508986
607PhosphorylationAAEQLAQTGECDPEE
HHHHHHHHCCCCHHH		29.3729743597
672PhosphorylationLEDVCADSVDAVQEL
HHHHHHHHHHHHHHH		11.9025159151
672 (in isoform 5)Phosphorylation-11.9022468782
673 (in isoform 5)Phosphorylation-5.8822468782
736 (in isoform 5)Phosphorylation-30.9925849741
955PhosphorylationSLQKTHQSALQVQQK
HHHHHHHHHHHHHHH		24.2830576142
1005PhosphorylationRLKLVNASVAFYKTS
HHHHHHHHHHHHHCH		14.5823403867
1009PhosphorylationVNASVAFYKTSEQVC
HHHHHHHHHCHHHHH		12.0123403867
1036MethylationDEDWCGGRDKLGPAA
CCCCCCCCCCCCCHH		24.1524151407
1079PhosphorylationNAEVFLKYIHRNNVS
CHHHHHHHHHHCCCC		12.2422468782
1086PhosphorylationYIHRNNVSMPSVASH
HHHHCCCCCCCHHCC		27.4022468782
1089PhosphorylationRNNVSMPSVASHTRG
HCCCCCCCHHCCCCC		22.9830631047
1092PhosphorylationVSMPSVASHTRGPEQ
CCCCCHHCCCCCHHH		24.2030631047
1120PhosphorylationNRVLHFWTLKKRRLD
CCHHEEEEEHHHCHH		27.9623403867
1182AcetylationGEFRVPAKQTKEKVK
CCCCCCHHHCHHHHH		53.057338271
1187AcetylationPAKQTKEKVKLLIQL
CHHHCHHHHHHHHHH		46.347338283
1215PhosphorylationEIRKWVTTVDKHYRD
HHHHHHHHHHHHHHH		19.6530576142
1230PhosphorylationFSLRMGKYRYSLEKA
HHHHCCCCCHHHHHH		14.7330301811
1232PhosphorylationLRMGKYRYSLEKALG
HHCCCCCHHHHHHHC		17.9530576142
1233PhosphorylationRMGKYRYSLEKALGV
HCCCCCHHHHHHHCC		22.5130576142
1256PhosphorylationELDIIPASLSDREVK
EEEEEECCCCCCEEH		24.05-
1421PhosphorylationPVQRITKYQLLLKEL
HHHHHHHHHHHHHHH		8.8528258704
1448PhosphorylationDGLEVMLSVPKKAND
CCEEEEEECCCCCCC		20.4824719451
1488PhosphorylationFQVWDPKSLIRKGRE
HHCCCHHHHHHCCCH		34.1224719451
1529PhosphorylationYKNKLLTSELGVTEH
EECCEEECCCCCCCC		30.6930576142
1551PhosphorylationFALWSGRTPSSDNKT
EEEEECCCCCCCCCE		30.9230576142
1607PhosphorylationPAKQRNNSKRDGVED
CHHHCCCCCCCCCCC		32.3925921289
1713PhosphorylationLCISHSRSSVEMDCF
HHHHCCCCCCCHHHH		41.5725850435
1714PhosphorylationCISHSRSSVEMDCFF
HHHCCCCCCCHHHHH		22.4626657352
1739PhosphorylationSSENGGKSESVANLQ
CCCCCCCCHHHHHCC		38.0828060719
1741PhosphorylationENGGKSESVANLQAQ
CCCCCCHHHHHCCCC		33.3528857561
1749PhosphorylationVANLQAQPSLNSIHS
HHHCCCCCCHHHHCC		43.7418088087
1750PhosphorylationANLQAQPSLNSIHSS
HHCCCCCCHHHHCCC		28.2722617229
1752PhosphorylationLQAQPSLNSIHSSPG
CCCCCCHHHHCCCCC		43.1618088087
1753PhosphorylationQAQPSLNSIHSSPGP
CCCCCHHHHCCCCCC		27.2930278072
1755PhosphorylationQPSLNSIHSSPGPKR
CCCHHHHCCCCCCCC		23.2618088087
1756PhosphorylationPSLNSIHSSPGPKRS
CCHHHHCCCCCCCCC		36.2428348404
1757PhosphorylationSLNSIHSSPGPKRST
CHHHHCCCCCCCCCH		21.5130278072
1763PhosphorylationSSPGPKRSTNTLKKW
CCCCCCCCHHHHHHH		31.94-
1772PhosphorylationNTLKKWLTSPVRRLN
HHHHHHHHCHHHHHC		29.8422167270
1773PhosphorylationTLKKWLTSPVRRLNS
HHHHHHHCHHHHHCC		21.1619664994
1780PhosphorylationSPVRRLNSGKADGNI
CHHHHHCCCCCCCCC		46.3825849741
1798PhosphorylationKKVRDGRKSFDLGSP
CCCCCCCCCCCCCCC		62.0918088087
1799PhosphorylationKVRDGRKSFDLGSPK
CCCCCCCCCCCCCCC		23.7223401153
1804PhosphorylationRKSFDLGSPKPGDET
CCCCCCCCCCCCCCC		36.7325849741
1811PhosphorylationSPKPGDETTPQGDSA
CCCCCCCCCCCCCCC		48.8221955146
1812PhosphorylationPKPGDETTPQGDSAD
CCCCCCCCCCCCCCC		16.1521955146
1816PhosphorylationDETTPQGDSADEKSK
CCCCCCCCCCCHHHC		35.0918088087
1817PhosphorylationETTPQGDSADEKSKK
CCCCCCCCCCHHHCC		44.4321955146
1822PhosphorylationGDSADEKSKKGWGED
CCCCCHHHCCCCCCC		37.2428060719
1835PhosphorylationEDEPDEESHTPLPPP
CCCCCCCCCCCCCCC		30.5222210691
1837PhosphorylationEPDEESHTPLPPPMK
CCCCCCCCCCCCCCC		35.4828060719
1851PhosphorylationKIFDNDPTQDEMSSL
CCCCCCCCHHHHHHH		52.0622210691
1856PhosphorylationDPTQDEMSSLLAARQ
CCCHHHHHHHHHHHH		18.7822210691
1857PhosphorylationPTQDEMSSLLAARQA
CCHHHHHHHHHHHHH		26.5422210691
1865PhosphorylationLLAARQASTEVPTAA
HHHHHHHCCCCCCHH		19.4327535140
1866PhosphorylationLAARQASTEVPTAAD
HHHHHHCCCCCCHHH		43.9828060719
1896PhosphorylationEGSSYRGSLKDPAGC
CCCCCCCCCCCCCCC		24.2128060719
1912PhosphorylationNEGMAPPTPPKNPEE
CCCCCCCCCCCCHHH		51.6822617229
1913PhosphorylationEGMAPPTPPKNPEEE
CCCCCCCCCCCHHHH		43.58-
1943PhosphorylationLVQTEKDYVKDLGIV
HHHCCHHHHHHHHHH		22.0718083107
2163PhosphorylationSELLRKGSLTPGYMF
HHHHHCCCCCCCHHH		31.9125849741
2164PhosphorylationELLRKGSLTPGYMFK
HHHHCCCCCCCHHHC		10.25-
2165PhosphorylationLLRKGSLTPGYMFKR
HHHCCCCCCCHHHCC		19.1628060719
2236PhosphorylationDFLNALQSPIEYQRK
HHHHHHHCHHHHHHH		28.7922617229
2237PhosphorylationFLNALQSPIEYQRKE
HHHHHHCHHHHHHHH		15.5224719451
2240PhosphorylationALQSPIEYQRKERST
HHHCHHHHHHHHHCC		17.8428060719
2261PhosphorylationPARLPQASPRPYSSV
CCCCCCCCCCCCCCC		19.0510023074
2262PhosphorylationARLPQASPRPYSSVP
CCCCCCCCCCCCCCC		44.2624719451
2265PhosphorylationPQASPRPYSSVPAGS
CCCCCCCCCCCCCCC		18.1728985074
2266PhosphorylationQASPRPYSSVPAGSE
CCCCCCCCCCCCCCC		27.7828060719
2267PhosphorylationASPRPYSSVPAGSEK
CCCCCCCCCCCCCCC		26.6928985074
2272PhosphorylationYSSVPAGSEKPPKGS
CCCCCCCCCCCCCCC		44.5528985074
2279PhosphorylationSEKPPKGSSYNPPLP
CCCCCCCCCCCCCCC		35.4621214269
2280PhosphorylationEKPPKGSSYNPPLPP
CCCCCCCCCCCCCCC		37.2823403867
2281PhosphorylationKPPKGSSYNPPLPPL
CCCCCCCCCCCCCCC		33.1321214269
2282PhosphorylationPPKGSSYNPPLPPLK
CCCCCCCCCCCCCCE		33.39-
2291PhosphorylationPLPPLKISTSNGSPG
CCCCCEEECCCCCCC		24.9728270605
2292PhosphorylationLPPLKISTSNGSPGF
CCCCEEECCCCCCCC		29.6828270605
2293PhosphorylationPPLKISTSNGSPGFE
CCCEEECCCCCCCCC		32.1928270605
2296PhosphorylationKISTSNGSPGFEYHQ
EEECCCCCCCCCCCC		26.5425849741
2301PhosphorylationNGSPGFEYHQPGDKF
CCCCCCCCCCCCCCC		11.9523312004
2311PhosphorylationPGDKFEASKQNDLGG
CCCCCCHHHCCCCCC		27.8121214269
2312PhosphorylationGDKFEASKQNDLGGC
CCCCCHHHCCCCCCC		61.23-
2391PhosphorylationTKATAAESSDGSIKK
HHCHHCCCCCCCHHH		29.0628060719
2392PhosphorylationKATAAESSDGSIKKS
HCHHCCCCCCCHHHH		37.1828060719
2395PhosphorylationAAESSDGSIKKSCSW
HCCCCCCCHHHHCCH		35.9025849741
2396PhosphorylationAESSDGSIKKSCSWH
CCCCCCCHHHHCCHH		8.7827251275
2401PhosphorylationGSIKKSCSWHTLRMR
CCHHHHCCHHHHHHH		29.0524719451
2402PhosphorylationSIKKSCSWHTLRMRK
CHHHHCCHHHHHHHH		7.8824719451
2436PhosphorylationDILGNKVSVKETNSS
CCCCCCCCCCCCCCC		29.13-
2559PhosphorylationDHGTTSTSATVKVQG
CCCCCCCEEEEEECC		23.01-
2715PhosphorylationDVAVKFVSKKMKKKE
HHHHHHHCHHCHHHH		29.6818187866
2716PhosphorylationVAVKFVSKKMKKKEQ
HHHHHHCHHCHHHHH		52.14-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
487SPhosphorylationKinaseMAPKAPK5Q8IW41
PSP
487SPhosphorylationKinaseMAPKAPK5O54992
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KALRN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KALRN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AMD_HUMANPAMphysical
9139723
GBB1_HUMANGNB1physical
10518015
SNCAP_HUMANSNCAIPphysical
23284848
DICER_HUMANDICER1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
608901Coronary heart disease 5 (CHDS5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KALRN_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1799 AND SER-2236, ANDMASS SPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1750; SER-1753;SER-1756; SER-1799; SER-1817 AND SER-2261, AND MASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1773, AND MASSSPECTROMETRY.

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