RIM3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIM3C_HUMAN
• UniProt AC: A6NJZ7
• Protein Name: RIMS-binding protein 3C
• Gene Name: RIMBP3C
• Organism: Homo sapiens (Human).
• Sequence Length: 1639
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Sequence: MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLIIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
150	Phosphorylation	LVNRGHCSRPGASEV HHHCCCCCCCCHHHC	35.52	-
155	Phosphorylation	HCSRPGASEVSAAQC CCCCCCHHHCCHHHH	44.43	-
158	Phosphorylation	RPGASEVSAAQCRCR CCCHHHCCHHHHHHH	17.52	-
260	Phosphorylation	SAEVGVRSRSLGLVS HCCCCCCCCCCCCCC	24.66	-
284	Phosphorylation	LLSTHASSLDCFAPA CHHCCHHHCCCCHHH	29.07	-
313	Phosphorylation	SKSEERPSSPDTSTP CCCCCCCCCCCCCCC	61.80	30576142
314	Phosphorylation	KSEERPSSPDTSTPG CCCCCCCCCCCCCCC	29.49	28634120
317	Phosphorylation	ERPSSPDTSTPGSRR CCCCCCCCCCCCCCC	37.57	28122231
318	Phosphorylation	RPSSPDTSTPGSRRL CCCCCCCCCCCCCCC	39.73	28122231
326	Phosphorylation	TPGSRRLSPPPSPLP CCCCCCCCCCCCCCC	33.28	25693802
330	Phosphorylation	RRLSPPPSPLPPPPP CCCCCCCCCCCCCCC	44.86	23532336
393	Phosphorylation	VLARRCYTLQEENKQ HHHHHHCHHHHHHHH	26.12	33259812
413	Ubiquitination	CPYQADEKVKRLKVK CCCCCCHHHHHHHHC	54.31	-
415	Ubiquitination	YQADEKVKRLKVKRA CCCCHHHHHHHHCHH	64.18	-
473	Phosphorylation	RQRARDLSEQASAPL HHHHHHHHHHCCCCH	31.77	22210691
477	Phosphorylation	RDLSEQASAPLAKDK HHHHHHCCCCHHHHH	30.07	22210691
482	Ubiquitination	QASAPLAKDKQIEEL HCCCCHHHHHHHHHH	73.47	-
484	Ubiquitination	SAPLAKDKQIEELRQ CCCHHHHHHHHHHHH	53.09	-
512	Methylation	CSDLHTGRGGPCTQW CCCCCCCCCCCCCCC	48.31	-
611	Ubiquitination	QLQAALLKNAWLAEE HHHHHHHHHHHHHHH	45.53	-
625	Ubiquitination	ENGRLQAKTDWVRKV HCCCEEECCCHHHHH	33.77	29967540
653	Phosphorylation	ACQERDASGLIAEQL HHHHHCCHHHHHHHH	38.12	25693802
732	Phosphorylation	FHARPEDYAVSQPNR CCCCHHHCCCCCCCH	13.77	27642862
816	Phosphorylation	VDDLEPDSVSLALEM CCCCCCCCHHEHHHC	25.07	23879269
818	Phosphorylation	DLEPDSVSLALEMGG CCCCCCHHEHHHCCC	16.33	23879269
826	Phosphorylation	LALEMGGSAAPAAPK EHHHCCCCCCCCCCE	18.61	23879269
952	Phosphorylation	CQMVRVGSKTEVATE HHHEECCCCCHHHHH	33.28	23186163
953	Ubiquitination	QMVRVGSKTEVATEI HHEECCCCCHHHHHH	42.66	-
964	Ubiquitination	ATEILDTKTEACQLG HHHHHCCCHHHHHHH	43.99	-
978	Ubiquitination	GLLQSMGKQGLSRPL HHHHHHCCCCCCCCC	32.33	29967540
989	Ubiquitination	SRPLLGTKGVLRMAP CCCCCCCHHHHHHCC	45.27	-
1025	Phosphorylation	HRHPHVVYLDDREHA CCCCEEEEECCCCCC	11.88	-
1217	Ubiquitination	TFPVCPQKLSLAPPS EECCCCCCCCCCCCC	25.78	-
1226	Ubiquitination	SLAPPSAKASPHNPG CCCCCCCCCCCCCCC	54.45	29967540
1228	Phosphorylation	APPSAKASPHNPGSC CCCCCCCCCCCCCCC	26.45	25159151
1255	Phosphorylation	EEPPRRQSPVSNLGS CCCCCCCCCCCCCCC	26.00	26074081
1258	Phosphorylation	PRRQSPVSNLGSEGE CCCCCCCCCCCCCCC	29.71	26074081
1262	Phosphorylation	SPVSNLGSEGECPSS CCCCCCCCCCCCCCC	45.66	26074081
1294	Phosphorylation	KDLLFQKSPQNHRPP HHHHCCCCCCCCCCC	22.42	25159151
1322	Phosphorylation	QHMGTSKSPAPGFIH CCCCCCCCCCCCEEE	26.51	-
1344	Ubiquitination	RKEPCQEKAALERVL CCCHHHHHHHHHHHH	17.06	-
1425	Phosphorylation	CQLHEPSSALCPAPS CCCCCCCCCCCCCCC	35.66	29116813
1434	Ubiquitination	LCPAPSAKVIKMPRG CCCCCCCCEEECCCC	49.16	-
1437	Ubiquitination	APSAKVIKMPRGGPQ CCCCCEEECCCCCCC	45.93	-
1452	Phosphorylation	QLGTGANTPARVFVA CCCCCCCCCCEEEEE	20.14	-
1483	Ubiquitination	EEELVFQKRQLLRVW HHHHHHCHHHHHHHH	30.55	-
1492	Phosphorylation	QLLRVWGSQDTHDFY HHHHHHCCCCHHHEH	14.79	-
1501	Phosphorylation	DTHDFYLSECNRQVG CHHHEHHHHHHHCCC	28.82	-
1592	Ubiquitination	GQMGGQGKGRLALRA CCCCCCCCCCEEEEC	32.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIM3C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIM3C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIM3C_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RIM3C_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.