SH3R2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3R2_HUMAN
• UniProt AC: Q8TEC5
• Protein Name: Putative E3 ubiquitin-protein ligase SH3RF2
• Gene Name: SH3RF2
• Organism: Homo sapiens (Human).
• Sequence Length: 729
• Protein Description: Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function..
• Protein Sequence: MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNIEALPANLLLVRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFVPTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSLQRPLQSGIPTLVVGSLRRSPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCISRGSEAWIHSAASSLIMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHYTSHPTSGKPEQPATLKASQPEAASLGPEMTVLFAHRSGCHSGQQTDLRRKSALGKATTLVSTASGTQTVFPSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Methylation	RSGQSSGRGGSFRRP HCCCCCCCCCCCCCC	48.52	115368451
87	Phosphorylation	QSSGRGGSFRRPGTM CCCCCCCCCCCCCEE	20.57	22210691
112	Phosphorylation	NPRRLQASPFRLVPN CCCCCCCCCCEECCC	16.17	23312004
234	Ubiquitination	DENWAEGKLGDKVGI CCCCCCCCCCCCCCE	40.58	-
272	Phosphorylation	SSRTKNLSLVSSSSR CCCCCCEEEEECCCC	35.80	26074081
275	Phosphorylation	TKNLSLVSSSSRGNT CCCEEEEECCCCCCC	29.78	26074081
276	Phosphorylation	KNLSLVSSSSRGNTS CCEEEEECCCCCCCC	25.50	26074081
277	Phosphorylation	NLSLVSSSSRGNTST CEEEEECCCCCCCCC	19.29	26074081
278	Phosphorylation	LSLVSSSSRGNTSTL EEEEECCCCCCCCCC	46.27	26074081
425	Phosphorylation	LRGVSLVTGRVGIFP ECCEEEECCCEEECC	25.27	24719451
451	Phosphorylation	SSFPDSRSPGLYTTW CCCCCCCCCCEEEEE	27.54	30576142
461	Phosphorylation	LYTTWTLSTSSVSSQ EEEEEEEECCCCCCC	20.90	30576142
466	Phosphorylation	TLSTSSVSSQGSISE EEECCCCCCCCCCCC	20.92	30576142
497	Phosphorylation	AIVNPVRSTAGPGTL EEECCCCCCCCCCCC	23.89	26437602
508	Phosphorylation	PGTLGQGSLRKGRSS CCCCCCCCCCCCCCC	19.67	26437602
642	Phosphorylation	GIEKQVKTVRFQNYS CCHHEEEEEEECCCC	20.32	22817900
648	Phosphorylation	KTVRFQNYSPPPTKH EEEEECCCCCCCCCC	16.27	26657352
649	Phosphorylation	TVRFQNYSPPPTKHY EEEECCCCCCCCCCC	38.18	25159151
653	Phosphorylation	QNYSPPPTKHYTSHP CCCCCCCCCCCCCCC	35.91	23090842
657	Phosphorylation	PPPTKHYTSHPTSGK CCCCCCCCCCCCCCC	21.93	-
658	Phosphorylation	PPTKHYTSHPTSGKP CCCCCCCCCCCCCCC	21.94	30576142
661	Phosphorylation	KHYTSHPTSGKPEQP CCCCCCCCCCCCCCC	44.69	30576142
670	Phosphorylation	GKPEQPATLKASQPE CCCCCCCEEECCCHH	35.16	22673903
674	Phosphorylation	QPATLKASQPEAASL CCCEEECCCHHHHHH	44.68	22673903
680	Phosphorylation	ASQPEAASLGPEMTV CCCHHHHHHCCCEEE	40.69	22673903
686	Phosphorylation	ASLGPEMTVLFAHRS HHHCCCEEEEEECCC	16.64	22673903
707	Phosphorylation	QTDLRRKSALGKATT CHHHHHHHHHCCCCE	27.24	-
713	Phosphorylation	KSALGKATTLVSTAS HHHHCCCCEEEECCC	24.93	-
717	Phosphorylation	GKATTLVSTASGTQT CCCCEEEECCCCCCC	22.74	30622161
718	Phosphorylation	KATTLVSTASGTQTV CCCEEEECCCCCCCC	19.84	30622161
720	Phosphorylation	TTLVSTASGTQTVFP CEEEECCCCCCCCCC	42.32	30622161
722	Phosphorylation	LVSTASGTQTVFPSK EEECCCCCCCCCCCC	20.69	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SH3R2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3R2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3R2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3R1_HUMAN	SH3RF1	physical	22128169
PP1A_HUMAN	PPP1CA	physical	19945436
A4_HUMAN	APP	physical	21832049
CCD50_HUMAN	CCDC50	physical	24130170
DDX1_HUMAN	DDX1	physical	24130170
DDX6_HUMAN	DDX6	physical	24130170
TDIF1_HUMAN	DNTTIP1	physical	24130170
IF4A1_HUMAN	EIF4A1	physical	24130170
G3BP1_HUMAN	G3BP1	physical	24130170
SYK_HUMAN	KARS	physical	24130170
LSM12_HUMAN	LSM12	physical	24130170
FAN_HUMAN	NSMAF	physical	24130170
NUFP2_HUMAN	NUFIP2	physical	24130170
PAK4_HUMAN	PAK4	physical	24130170
PIMT_HUMAN	PCMT1	physical	24130170
RD23A_HUMAN	RAD23A	physical	24130170
U2AF2_HUMAN	U2AF2	physical	24130170
SPERT_HUMAN	SPERT	physical	25416956
CENPJ_HUMAN	CENPJ	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.