FAN_HUMAN - dbPTM
FAN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FAN_HUMAN
UniProt AC Q92636
Protein Name Protein FAN
Gene Name NSMAF
Organism Homo sapiens (Human).
Sequence Length 917
Subcellular Localization
Protein Description Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE..
Protein Sequence MAFIRKKQQEQQLQLYSKERFSLLLLNLEEYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLRDCIKIGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationQEQQLQLYSKERFSL
HHHHHHHHCHHHHHH		12.5325159151
18UbiquitinationQQLQLYSKERFSLLL
HHHHHHCHHHHHHHH		39.0824816145
36 (in isoform 2)Phosphorylation-24.5124719451
36PhosphorylationEEYYFEQHRANHILH
HHHHHHHHHHHHHHC		24.5124719451
61UbiquitinationGSLKICSKSVIFEPD
CCEEECCCEEEECCC		44.3129967540
76UbiquitinationSISQPIIKIPLRDCI
CCCCCEEEEEHHHHH		38.70-
84UbiquitinationIPLRDCIKIGKHGEN
EEHHHHHHCCCCCCC		52.30-
92UbiquitinationIGKHGENGANRHFTK
CCCCCCCCCCCCCCC		21.6729967540
107 (in isoform 2)Ubiquitination-4.30-
113PhosphorylationSLIFSQVYFIKEHNV
EEEEEEEEEEHHCCE		7.61-
115 (in isoform 2)Ubiquitination-2.54-
180PhosphorylationLQSRLARTSFDKNRF
HHHHHHCCCCCCCCC		28.3022985185
181PhosphorylationQSRLARTSFDKNRFQ
HHHHHCCCCCCCCCC		26.3722985185
368UbiquitinationKPVGALNKERLERLL
CCCCCCCHHHHHHHH		45.0929967540
388PhosphorylationMPEPKFMYGSHYSSP
CCCCCCCCCCCCCCC		20.7118452278
397PhosphorylationSHYSSPGYVLFYLVR
CCCCCCHHHHEEEEE		9.4318452278
399UbiquitinationYSSPGYVLFYLVRIA
CCCCHHHHEEEEECC		1.4329967540
399 (in isoform 2)Ubiquitination-1.43-
401PhosphorylationSPGYVLFYLVRIAPE
CCHHHHEEEEECCHH		10.5018452278
450PhosphorylationKELIPEFYGDDVSFL
HHHHHHHHCCHHHHH		20.2730576142
467UbiquitinationSLKLDLGKRQGGQMV
HCCCCCCCCCCCCCC		49.17-
492UbiquitinationSPEDFLQKSKDALES
CHHHHHHHCHHHHHH		62.7129967540
523UbiquitinationYKQKGSDAVGAHNVF
CCCCCCCCCCCCCCC		11.8929967540
577PhosphorylationTPHPRRITPKFKSLS
CCCCCCCCCCCCCHH		20.72-
582PhosphorylationRITPKFKSLSQTSSY
CCCCCCCCHHCCCCC		36.0629978859
584PhosphorylationTPKFKSLSQTSSYNA
CCCCCCHHCCCCCCH		38.2029978859
586PhosphorylationKFKSLSQTSSYNASM
CCCCHHCCCCCCHHH		19.1029978859
587PhosphorylationFKSLSQTSSYNASMA
CCCHHCCCCCCHHHC		24.1628348404
588PhosphorylationKSLSQTSSYNASMAD
CCHHCCCCCCHHHCC		26.2928348404
589PhosphorylationSLSQTSSYNASMADS
CHHCCCCCCHHHCCC		17.9528348404
592PhosphorylationQTSSYNASMADSPGE
CCCCCCHHHCCCCCC		15.7428348404
596PhosphorylationYNASMADSPGEESFE
CCHHHCCCCCCCCHH		25.8522199227
601PhosphorylationADSPGEESFEDLTEE
CCCCCCCCHHHHCHH		29.6322199227
606PhosphorylationEESFEDLTEESKTLA
CCCHHHHCHHHHHHH		50.4522199227
609PhosphorylationFEDLTEESKTLAWNN
HHHHCHHHHHHHHCC		25.3822199227
611PhosphorylationDLTEESKTLAWNNIT
HHCHHHHHHHHCCCC		30.8722817900
618PhosphorylationTLAWNNITKLQLHEH
HHHHCCCCEEEHHHH		28.0322817900
626PhosphorylationKLQLHEHYKIHKEAV
EEEHHHHHCCCHHHC		14.51-
632PhosphorylationHYKIHKEAVTGITVS
HHCCCHHHCCEEEEE		14.6927251275
634PhosphorylationKIHKEAVTGITVSRN
CCCHHHCCEEEEECC		29.8924888630
637PhosphorylationKEAVTGITVSRNGSS
HHHCCEEEEECCCCE		17.4924888630
649PhosphorylationGSSVFTTSQDSTLKM
CCEEEEECCCCHHHH		29.00-
658PhosphorylationDSTLKMFSKESKMLQ
CCHHHHHHHHHHHHH		31.83-
676PhosphorylationSFSNMALSSCLLLPG
HHCHHHHHHCEECCC		14.96-
740PhosphorylationDSTVKVWSGVPAEMP
CCCEEEECCCCCCCC		32.66-
750UbiquitinationPAEMPGTKRHHFDLL
CCCCCCCCCCHHHHH		56.5022817900
750AcetylationPAEMPGTKRHHFDLL
CCCCCCCCCCHHHHH		56.5025953088
781UbiquitinationASTLLVSGTKEGTVN
CCEEEEECCCCCEEE		33.0722817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FAN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FAN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FAN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RACK1_HUMANGNB2L1physical
12391233
TNR1A_HUMANTNFRSF1Aphysical
8808629
NEK9_HUMANNEK9physical
20562859
XIRP2_HUMANXIRP2physical
20562859
ACTB_HUMANACTBphysical
17599063
VASP_HUMANVASPphysical
17599063
TCPZ_HUMANCCT6Aphysical
26496610
E41L2_HUMANEPB41L2physical
26496610
PFD2_HUMANPFDN2physical
26496610
TCPA_HUMANTCP1physical
26496610
TCPG_HUMANCCT3physical
26496610
TCPH_HUMANCCT7physical
26496610
TCPD_HUMANCCT4physical
26496610
TCPB_HUMANCCT2physical
26496610
TCPQ_HUMANCCT8physical
26496610
TCPE_HUMANCCT5physical
26496610
FXL19_HUMANFBXL19physical
26496610
DOCK8_HUMANDOCK8physical
26496610
DCP1_YEASTDCP1physical
26133670
DCP1A_HUMANDCP1Aphysical
26133670
DCP1B_HUMANDCP1Bphysical
26133670
DCP1_ARATHDCP1physical
26133670
HPHL1_HUMANHEPHL1physical
28514442
LYG2_HUMANLYG2physical
28514442
PPCE_HUMANPREPphysical
28514442
SBP1_HUMANSELENBP1physical
28514442
GBRL1_HUMANGABARAPL1physical
28514442
DSG4_HUMANDSG4physical
28514442
DUS14_HUMANDUSP14physical
28514442
TRHY_HUMANTCHHphysical
28514442
PKP3_HUMANPKP3physical
28514442
FA26D_HUMANFAM26Dphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FAN_HUMAN

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Related Literatures of Post-Translational Modification

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