dbPTM

PKP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKP3_HUMAN
UniProt AC	Q9Y446
Protein Name	Plakophilin-3
Gene Name	PKP3
Organism	Homo sapiens (Human).
Sequence Length	797
Subcellular Localization	Nucleus. Cell junction, desmosome. Nuclear and associated with desmosomes.
Protein Description	May play a role in junctional plaques..
Protein Sequence	MQDGNFLLSALQPEAGVCSLALPSDLQLDRRGAEGPEAERLRAARVQEQVRARLLQLGQQPRHNGAAEPEPEAETARGTSRGQYHTLQAGFSSRSQGLSGDKTSGFRPIAKPAYSPASWSSRSAVDLSCSRRLSSAHNGGSAFGAAGYGGAQPTPPMPTRPVSFHERGGVGSRADYDTLSLRSLRLGPGGLDDRYSLVSEQLEPAATSTYRAFAYERQASSSSSRAGGLDWPEATEVSPSRTIRAPAVRTLQRFQSSHRSRGVGGAVPGAVLEPVARAPSVRSLSLSLADSGHLPDVHGFNSYGSHRTLQRLSSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALVTSINHALDAGKCEDKSVENAVCVLRNLSYRLYDEMPPSALQRLEGRGRRDLAGAPPGEVVGCFTPQSRRLRELPLAADALTFAEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQERILNPLLDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKSPPAEVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLIFIKKKRDSPDSEKSSRAASSLLANLWQYNKLHRDFRAKGYRKEDFLGP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	QDGNFLLSALQPEAG CCCCCHHHHCCCCCC	29.13	28348404
19	Phosphorylation	QPEAGVCSLALPSDL CCCCCCCCEECCCCC	17.80	27470641
24	Phosphorylation	VCSLALPSDLQLDRR CCCEECCCCCCCCCC	52.37	28348404
75	Phosphorylation	EPEPEAETARGTSRG CCCCHHHHCCCCCCC	28.80	27470641
79	Phosphorylation	EAETARGTSRGQYHT HHHHCCCCCCCHHEE	15.08	27470641
80	Phosphorylation	AETARGTSRGQYHTL HHHCCCCCCCHHEEE	36.92	25394399
81	Methylation	ETARGTSRGQYHTLQ HHCCCCCCCHHEEEC	35.75	24129315
84	Phosphorylation	RGTSRGQYHTLQAGF CCCCCCHHEEECCCC	10.29	21945579
86	Phosphorylation	TSRGQYHTLQAGFSS CCCCHHEEECCCCCC	18.68	21945579
92	Phosphorylation	HTLQAGFSSRSQGLS EEECCCCCCCCCCCC	24.75	21945579
93	Phosphorylation	TLQAGFSSRSQGLSG EECCCCCCCCCCCCC	33.42	21945579
95	Phosphorylation	QAGFSSRSQGLSGDK CCCCCCCCCCCCCCC	30.46	22617229
99	Phosphorylation	SSRSQGLSGDKTSGF CCCCCCCCCCCCCCC	52.34	20068231
102	Ubiquitination	SQGLSGDKTSGFRPI CCCCCCCCCCCCCCC	48.38	29967540
103	Phosphorylation	QGLSGDKTSGFRPIA CCCCCCCCCCCCCCC	38.53	21945579
104	Phosphorylation	GLSGDKTSGFRPIAK CCCCCCCCCCCCCCC	41.49	21945579
111	Acetylation	SGFRPIAKPAYSPAS CCCCCCCCCCCCCCC	30.79	26051181
114	Phosphorylation	RPIAKPAYSPASWSS CCCCCCCCCCCCCCC	24.58	21945579
115	Phosphorylation	PIAKPAYSPASWSSR CCCCCCCCCCCCCCC	18.98	21945579
117	Ubiquitination	AKPAYSPASWSSRSA CCCCCCCCCCCCCCC	20.07	29967540
118	Phosphorylation	KPAYSPASWSSRSAV CCCCCCCCCCCCCCH	30.76	21945579
120	Phosphorylation	AYSPASWSSRSAVDL CCCCCCCCCCCCHHH	17.24	21945579
121	Phosphorylation	YSPASWSSRSAVDLS CCCCCCCCCCCHHHH	24.81	21945579
123	Phosphorylation	PASWSSRSAVDLSCS CCCCCCCCCHHHHHH	34.29	28355574
128	Phosphorylation	SRSAVDLSCSRRLSS CCCCHHHHHHCCHHH	12.94	23927012
130	Phosphorylation	SAVDLSCSRRLSSAH CCHHHHHHCCHHHCC	19.63	23927012
134	Phosphorylation	LSCSRRLSSAHNGGS HHHHCCHHHCCCCCC	24.54	26657352
135	Phosphorylation	SCSRRLSSAHNGGSA HHHCCHHHCCCCCCC	37.83	28188228
141	Phosphorylation	SSAHNGGSAFGAAGY HHCCCCCCCCCCCCC	23.09	28152594
148	Phosphorylation	SAFGAAGYGGAQPTP CCCCCCCCCCCCCCC	13.99	23927012
154	Phosphorylation	GYGGAQPTPPMPTRP CCCCCCCCCCCCCCC	28.13	28152594
159	Phosphorylation	QPTPPMPTRPVSFHE CCCCCCCCCCCCCCC	41.16	28152594
163	Phosphorylation	PMPTRPVSFHERGGV CCCCCCCCCCCCCCC	24.46	28152594
172	Phosphorylation	HERGGVGSRADYDTL CCCCCCCCCCCCCCC	23.14	21945579
176	Phosphorylation	GVGSRADYDTLSLRS CCCCCCCCCCCCCCC	15.16	25159151
178	Phosphorylation	GSRADYDTLSLRSLR CCCCCCCCCCCCCEE	16.42	21945579
180	Phosphorylation	RADYDTLSLRSLRLG CCCCCCCCCCCEECC	24.67	23927012
183	Phosphorylation	YDTLSLRSLRLGPGG CCCCCCCCEECCCCC	24.12	28355574
195	Phosphorylation	PGGLDDRYSLVSEQL CCCCHHHHHHHHHCC	17.22	21945579
196	Phosphorylation	GGLDDRYSLVSEQLE CCCHHHHHHHHHCCC	24.16	21945579
199	Phosphorylation	DDRYSLVSEQLEPAA HHHHHHHHHCCCCCC	25.56	21945579
207	Phosphorylation	EQLEPAATSTYRAFA HCCCCCCCHHHHHHH	24.57	21945579
208	Phosphorylation	QLEPAATSTYRAFAY CCCCCCCHHHHHHHH	20.79	21945579
209	Phosphorylation	LEPAATSTYRAFAYE CCCCCCHHHHHHHHH	16.81	21945579
210	Phosphorylation	EPAATSTYRAFAYER CCCCCHHHHHHHHHH	10.34	21945579
215	Phosphorylation	STYRAFAYERQASSS HHHHHHHHHHHCCCC	12.75	25106551
220	Phosphorylation	FAYERQASSSSSRAG HHHHHHCCCCCCCCC	23.55	21406692
221	Phosphorylation	AYERQASSSSSRAGG HHHHHCCCCCCCCCC	36.94	21406692
222	Phosphorylation	YERQASSSSSRAGGL HHHHCCCCCCCCCCC	29.82	21406692
223	Phosphorylation	ERQASSSSSRAGGLD HHHCCCCCCCCCCCC	26.28	21406692
224	Phosphorylation	RQASSSSSRAGGLDW HHCCCCCCCCCCCCC	28.26	33259812
235	Phosphorylation	GLDWPEATEVSPSRT CCCCCCCCCCCCCCC	34.95	30266825
238	Phosphorylation	WPEATEVSPSRTIRA CCCCCCCCCCCCCCC	15.78	19664994
239	Phosphorylation	PEATEVSPSRTIRAP CCCCCCCCCCCCCCC	32.76	33259812
240	Phosphorylation	EATEVSPSRTIRAPA CCCCCCCCCCCCCCH	34.25	30266825
242	Phosphorylation	TEVSPSRTIRAPAVR CCCCCCCCCCCCHHH	21.10	28857561
250	Phosphorylation	IRAPAVRTLQRFQSS CCCCHHHHHHHHHHH	22.20	28857561
256	Phosphorylation	RTLQRFQSSHRSRGV HHHHHHHHHHHHCCC	25.96	24719451
257	Phosphorylation	TLQRFQSSHRSRGVG HHHHHHHHHHHCCCC	16.49	27282143
260	Phosphorylation	RFQSSHRSRGVGGAV HHHHHHHHCCCCCCC	28.14	23312004
261	Methylation	FQSSHRSRGVGGAVP HHHHHHHCCCCCCCC	43.71	24129315
280	Phosphorylation	EPVARAPSVRSLSLS HCCCCCCCCCEEEEE	29.22	27273156
283	Phosphorylation	ARAPSVRSLSLSLAD CCCCCCCEEEEEHHH	21.83	27273156
285	Phosphorylation	APSVRSLSLSLADSG CCCCCEEEEEHHHCC	19.70	27273156
287	Phosphorylation	SVRSLSLSLADSGHL CCCEEEEEHHHCCCC	20.38	23927012
291	Phosphorylation	LSLSLADSGHLPDVH EEEEHHHCCCCCCCC	23.62	23927012
302	Phosphorylation	PDVHGFNSYGSHRTL CCCCCCCCCCCHHHH	28.72	23927012
303	Phosphorylation	DVHGFNSYGSHRTLQ CCCCCCCCCCHHHHH	24.61	23927012
305	Phosphorylation	HGFNSYGSHRTLQRL CCCCCCCCHHHHHHH	11.10	23927012
308	Phosphorylation	NSYGSHRTLQRLSSG CCCCCHHHHHHHHCC	23.09	30266825
313	Phosphorylation	HRTLQRLSSGFDDID HHHHHHHHCCCCCCC	30.51	20201521
314	Phosphorylation	RTLQRLSSGFDDIDL HHHHHHHCCCCCCCH	48.33	20201521
323	Phosphorylation	FDDIDLPSAVKYLMA CCCCCHHHHHHHHHH	53.65	23927012
327	Phosphorylation	DLPSAVKYLMASDPN CHHHHHHHHHHCCCC	8.63	26657352
331	Phosphorylation	AVKYLMASDPNLQVL HHHHHHHCCCCCEEE	39.37	30278072
342	Phosphorylation	LQVLGAAYIQHKCYS CEEECHHHHHHHHCC	10.69	20068231
349	Phosphorylation	YIQHKCYSDAAAKKQ HHHHHHCCHHHHHHH	30.18	27251275
359	Phosphorylation	AAKKQARSLQAVPRL HHHHHHHHHHHHHHH	28.05	20873877
390	Phosphorylation	GAMRNLIYDNADNKL HHHHHHHHCCCCCEE	13.30	21082442
396	Ubiquitination	IYDNADNKLALVEEN HHCCCCCEEEEEHHC	35.37	29967540
411	Ubiquitination	GIFELLRTLREQDDE CHHHHHHHHHHCCHH	30.09	29967540
424	Phosphorylation	DELRKNVTGILWNLS HHHHHHHHHHHHCCC	28.09	20068231
431	Phosphorylation	TGILWNLSSSDHLKD HHHHHCCCCCHHHHH	25.28	20068231
432	Phosphorylation	GILWNLSSSDHLKDR HHHHCCCCCHHHHHH	42.84	20068231
433	Phosphorylation	ILWNLSSSDHLKDRL HHHCCCCCHHHHHHH	26.18	20068231
437	2-Hydroxyisobutyrylation	LSSSDHLKDRLARDT CCCCHHHHHHHHHHH	37.06	-
518	Ubiquitination	NHALDAGKCEDKSVE HHHHHCCCCCCCCHH	35.85	29967540
533	Ubiquitination	NAVCVLRNLSYRLYD HHHHHHHHCHHHCCC	29.22	29967540
539	Phosphorylation	RNLSYRLYDEMPPSA HHCHHHCCCCCCHHH	10.81	21253578
545	Phosphorylation	LYDEMPPSALQRLEG CCCCCCHHHHHHHCC	35.42	24043423
569	S-palmitoylation	PPGEVVGCFTPQSRR CCCCEEEEECCCCHH	2.01	25002405
571	Phosphorylation	GEVVGCFTPQSRRLR CCEEEEECCCCHHHH	25.21	21712546
574	Phosphorylation	VGCFTPQSRRLRELP EEEECCCCHHHHHCC	22.14	30183078
594	Ubiquitination	LTFAEVSKDPKGLEW HHHHHHCCCCCCCHH	81.08	29967540
609	Ubiquitination	LWSPQIVGLYNRLLQ HCCHHHHHHHHHHHH	24.87	29967540
647	Phosphorylation	RRWAGVLSRLALEQE HHHHHHHHHHHHHHH	23.89	24719451
666	Phosphorylation	PLLDRVRTADHHQLR HHHHHHHHCCHHHHH	33.31	25599653
674	Phosphorylation	ADHHQLRSLTGLIRN CCHHHHHHHHHHHHH	38.58	20873877
676	Phosphorylation	HHQLRSLTGLIRNLS HHHHHHHHHHHHHHH	31.05	20873877
695	Ubiquitination	NKDEMSTKVVSHLIE CHHHHHHHHHHHHHH	33.08	29967540
703	Ubiquitination	VVSHLIEKLPGSVGE HHHHHHHHCCCCCCC	53.65	29967540
710	Ubiquitination	KLPGSVGEKSPPAEV HCCCCCCCCCCCHHH	48.48	29967540
718	Ubiquitination	KSPPAEVLVNIIAVL CCCCHHHHHHHHHHH	1.51	29967540
741	Phosphorylation	IAARDLLYFDGLRKL HHHHHHHHHCCHHHE	13.61	28152594
752	Acetylation	LRKLIFIKKKRDSPD HHHEEEEEECCCCCC	41.30	130667
757	Phosphorylation	FIKKKRDSPDSEKSS EEEECCCCCCCHHHH	34.34	29514088
760	Phosphorylation	KKRDSPDSEKSSRAA ECCCCCCCHHHHHHH	50.76	29514088
768	Phosphorylation	EKSSRAASSLLANLW HHHHHHHHHHHHHHH	22.12	28348404
769	Phosphorylation	KSSRAASSLLANLWQ HHHHHHHHHHHHHHH	23.75	28348404
791	Ubiquitination	FRAKGYRKEDFLGP- HHHCCCCHHHCCCC-	53.83	29967540
806	Ubiquitination	---------------- ----------------		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
195	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DSG1_HUMAN	DSG1	physical	12707304
DSG2_HUMAN	DSG2	physical	12707304
DSG3_HUMAN	DSG3	physical	12707304
DSC1_HUMAN	DSC1	physical	12707304
DSC2_HUMAN	DSC2	physical	12707304
DSC3_HUMAN	DSC3	physical	12707304
PLAK_HUMAN	JUP	physical	12707304
K1C18_HUMAN	KRT18	physical	12707304
DESP_HUMAN	DSP	physical	12707304

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKP3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-238; SER-240;SER-313 AND SER-314, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.	15302935 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-84; TYR-176; TYR-195 ANDTYR-390, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-84; TYR-176; TYR-195 ANDTYR-390, AND MASS SPECTROMETRY.	17389395 [Abstract]
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules."; Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.; Mol. Cell. Proteomics 4:1240-1250(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-84 AND TYR-195, AND MASSSPECTROMETRY.	15951569 [Abstract]