DSG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DSG3_HUMAN
• UniProt AC: P32926
• Protein Name: Desmoglein-3
• Gene Name: DSG3
• Organism: Homo sapiens (Human).
• Sequence Length: 999
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
• Protein Description: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion..
• Protein Sequence: MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	RIETKGQYDEEEMTM EEEECCCCCHHHHHH	33.71	-
65	Phosphorylation	CREGEDNSKRNPIAK CCCCCCCCCCCCCHH	45.36	30301811
110	N-linked_Glycosylation	DKNTGDINITAIVDR ECCCCCEEEEEEECC	30.23	UniProtKB CARBOHYD
180	N-linked_Glycosylation	NSLVMILNATDADEP CEEEEEEECCCCCCC	29.84	UniProtKB CARBOHYD
387	Phosphorylation	GIAFRPASKTFTVQK CEEEEECCCEEEEEC	34.61	20058876
389	Phosphorylation	AFRPASKTFTVQKGI EEEECCCEEEEECCC	23.26	-
391	Phosphorylation	RPASKTFTVQKGISS EECCCEEEEECCCCH	27.53	-
404	Phosphorylation	SSKKLVDYILGTYQA CHHHHHHHHHHHHCC	7.20	29759185
408	Phosphorylation	LVDYILGTYQAIDED HHHHHHHHHCCCCCC	14.71	29759185
416	Phosphorylation	YQAIDEDTNKAASNV HCCCCCCCCCHHHCC	36.25	29759185
459	N-linked_Glycosylation	RDSTFIVNKTITAEV CCCEEEEECCEEEEE	30.82	16740002
545	N-linked_Glycosylation	VWSITTLNATSALLR EEEEEECCHHHHHHH	38.80	16740002
545	N-linked_Glycosylation	VWSITTLNATSALLR EEEEEECCHHHHHHH	38.80	17623646
601	O-linked_Glycosylation	ICGTSYPTTSPGTRY CCCCCCCCCCCCCCC	31.50	55828611
602	O-linked_Glycosylation	CGTSYPTTSPGTRYG CCCCCCCCCCCCCCC	28.55	55828615
603	Phosphorylation	GTSYPTTSPGTRYGR CCCCCCCCCCCCCCC	24.66	20068231
606	Phosphorylation	YPTTSPGTRYGRPHS CCCCCCCCCCCCCCC	24.89	20068231
608	Phosphorylation	TTSPGTRYGRPHSGR CCCCCCCCCCCCCCC	19.82	22964224
690	Phosphorylation	NICVPPVTANGADFM CEECCCCCCCCCHHH	21.85	28348404
699	Phosphorylation	NGADFMESSEVCTNT CCCHHHCCCCCCCCC	21.73	28348404
700	Phosphorylation	GADFMESSEVCTNTY CCHHHCCCCCCCCCC	22.27	28348404
716	Phosphorylation	RGTAVEGTSGMEMTT CCCCEECCCCCCEEE	14.49	28348404
717	Phosphorylation	GTAVEGTSGMEMTTK CCCEECCCCCCEEEC	47.18	24719451
723	Phosphorylation	TSGMEMTTKLGAATE CCCCCEEECCCEEEC	23.98	-
731	Phosphorylation	KLGAATESGGAAGFA CCCEEECCCCCCCCC	37.87	24275569
739	Phosphorylation	GGAAGFATGTVSGAA CCCCCCCCCCCCCCC	30.99	24275569
743	Phosphorylation	GFATGTVSGAASGFG CCCCCCCCCCCCCCC	23.66	25332170
747	Phosphorylation	GTVSGAASGFGAATG CCCCCCCCCCCCCCC	33.84	25332170
759	Phosphorylation	ATGVGICSSGQSGTM CCCEEECCCCCCCCC	35.27	24275569
760	Phosphorylation	TGVGICSSGQSGTMR CCEEECCCCCCCCCE	36.12	25332170
765	Phosphorylation	CSSGQSGTMRTRHST CCCCCCCCCEEECCC	14.55	24275569
768	Phosphorylation	GQSGTMRTRHSTGGT CCCCCCEEECCCCCC	23.16	24719451
771	Phosphorylation	GTMRTRHSTGGTNKD CCCEEECCCCCCCCC	26.00	26356563
772	Phosphorylation	TMRTRHSTGGTNKDY CCEEECCCCCCCCCC	33.24	26356563
775	Phosphorylation	TRHSTGGTNKDYADG EECCCCCCCCCCCCC	40.20	26356563
779	Phosphorylation	TGGTNKDYADGAISM CCCCCCCCCCCCCCH	14.27	26356563
785	Phosphorylation	DYADGAISMNFLDSY CCCCCCCCHHHHHHH	13.72	27251275
860	Phosphorylation	FKKLAEISLGVDGEG HHHHHEEECCCCCCC	15.58	28348404
883	Phosphorylation	DSGYGIESCGHPIEV CCCCCCCCCCCCEEE	24.39	28348404
970	Phosphorylation	ERVICPISSVPGNLA EEEEEECCCCCCCCC	15.49	20639409
971	Phosphorylation	RVICPISSVPGNLAG EEEEECCCCCCCCCC	32.81	26657352
980	Phosphorylation	PGNLAGPTQLRGSHT CCCCCCCCCCCCCCE	39.04	20639409
985	Phosphorylation	GPTQLRGSHTMLCTE CCCCCCCCCEEEECC	14.89	26657352
987	Phosphorylation	TQLRGSHTMLCTEDP CCCCCCCEEEECCCC	17.34	23927012
991	Phosphorylation	GSHTMLCTEDPCSRL CCCEEEECCCCHHCC	39.19	23927012
996	Phosphorylation	LCTEDPCSRLI---- EECCCCHHCCC----	35.19	20639409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DSG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DSG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DSG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLAK_HUMAN	JUP	physical	7738346

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry.";
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.;
J. Proteome Res. 5:1493-1503(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-459 AND ASN-545, AND MASSSPECTROMETRY.
PubMed: 16740002