DSC2_HUMAN - dbPTM
DSC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DSC2_HUMAN
UniProt AC Q02487
Protein Name Desmocollin-2 {ECO:0000303|PubMed:28256248}
Gene Name DSC2 {ECO:0000312|HGNC:HGNC:3036}
Organism Homo sapiens (Human).
Sequence Length 901
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Cell junction, desmosome .
Protein Description Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms..
Protein Sequence MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34N-linked_GlycosylationFASDACKNVTLHVPS
HHCHHCCCCEEECCC		31.71UniProtKB CARBOHYD
134AcetylationEKVLRRAKRRWAPIP
HHHHHHHHHHCCCCC		40.467265005
166N-linked_GlycosylationVQSDTAQNYTIYYSI
HHCCCCCCEEEEEEE		33.19UniProtKB CARBOHYD
172PhosphorylationQNYTIYYSIRGPGVD
CCEEEEEEEECCCCC		6.7224719451
275PhosphorylationTDKDEPDTMHTRLKY
CCCCCCCCCCCEEEE		22.9022210691
278PhosphorylationDEPDTMHTRLKYSII
CCCCCCCCEEEEEEE		27.20-
283PhosphorylationMHTRLKYSIIGQVPP
CCCEEEEEEEECCCC		13.2228165663
291PhosphorylationIIGQVPPSPTLFSMH
EEECCCCCCCEEECC		25.1722210691
293PhosphorylationGQVPPSPTLFSMHPT
ECCCCCCCEEECCCC		44.7828165663
296PhosphorylationPPSPTLFSMHPTTGV
CCCCCEEECCCCCCE		21.2128165663
309PhosphorylationGVITTTSSQLDRELI
CEEEECCHHHCHHHH		32.4428165663
359PhosphorylationLPTFTRTSYVTSVEE
CCCCEECEEEEEEEE		17.8325954137
360PhosphorylationPTFTRTSYVTSVEEN
CCCEECEEEEEEEEC		13.7225954137
363PhosphorylationTRTSYVTSVEENTVD
EECEEEEEEEECEEE		19.9325954137
368PhosphorylationVTSVEENTVDVEILR
EEEEEECEEEEEEEE		22.7425954137
386PhosphorylationEDKDLVNTANWRANY
CCHHHHCCCCEEEEE		17.56-
392N-linked_GlycosylationNTANWRANYTILKGN
CCCCEEEEEEEEECC		26.3816740002
490PhosphorylationNAEVGTTSNGYKAYD
CCEECCCCCCCCCCC		28.2622496350
524PhosphorylationWVTIDENTGSIKVFR
CEEEECCCCCEEEEE		30.20-
526PhosphorylationTIDENTGSIKVFRSL
EEECCCCCEEEEECC		19.73-
545PhosphorylationETIKNGIYNITVLAS
HHHHCCEEEEEEEEE		11.2525690035
546N-linked_GlycosylationTIKNGIYNITVLASD
HHHCCEEEEEEEEEC		22.8716335952
552PhosphorylationYNITVLASDQGGRTC
EEEEEEEECCCCCCC		26.7225690035
611PhosphorylationHGPPFDFSLESSTSE
CCCCCCCCCCCCHHH		32.8325332170
616PhosphorylationDFSLESSTSEVQRMW
CCCCCCCHHHHHHHH		37.8825332170
629N-linked_GlycosylationMWRLKAINDTAARLS
HHHHHHHHHHHHHHH		45.5016740002
740PhosphorylationAQQNLIVSNTEAPGD
HHCCEEEECCCCCCC		30.9228348404
751PhosphorylationAPGDDKVYSANGFTT
CCCCCCEEECCCEEE		14.0622817900
752PhosphorylationPGDDKVYSANGFTTQ
CCCCCEEECCCEEEC		20.4628348404
760PhosphorylationANGFTTQTVGASAQG
CCCEEECCCCCCCCC		20.86-
764PhosphorylationTTQTVGASAQGVCGT
EECCCCCCCCCCCCC		18.3928348404
783PhosphorylationIKNGGQETIEMVKGG
CCCCCCEEEEEEECC		17.8525056879
793PhosphorylationMVKGGHQTSESCRGA
EEECCCCCCCCCCCC		28.8724719451
794PhosphorylationVKGGHQTSESCRGAG
EECCCCCCCCCCCCC		22.4222798277
796PhosphorylationGGHQTSESCRGAGHH
CCCCCCCCCCCCCCC		14.6429496963
805PhosphorylationRGAGHHHTLDSCRGG
CCCCCCCCCCCCCCC		28.0923927012
808PhosphorylationGHHHTLDSCRGGHTE
CCCCCCCCCCCCCCE		14.6123927012
810MethylationHHTLDSCRGGHTEVD
CCCCCCCCCCCCEEE		59.07-
814PhosphorylationDSCRGGHTEVDNCRY
CCCCCCCCEEECCEE		40.7623927012
821PhosphorylationTEVDNCRYTYSEWHS
CEEECCEEEECCCCC		16.5420007894
822PhosphorylationEVDNCRYTYSEWHSF
EEECCEEEECCCCCC		10.9621082442
823PhosphorylationVDNCRYTYSEWHSFT
EECCEEEECCCCCCC		8.8227273156
824PhosphorylationDNCRYTYSEWHSFTQ
ECCEEEECCCCCCCC		26.8127273156
828PhosphorylationYTYSEWHSFTQPRLG
EEECCCCCCCCCCCC		30.9426356563
830PhosphorylationYSEWHSFTQPRLGEK
ECCCCCCCCCCCCCE		40.4526356563
838PhosphorylationQPRLGEKVYLCNQDE
CCCCCCEEEEECCCC		3.7227251275
838 (in isoform 2)Phosphorylation-3.7225056879
839PhosphorylationPRLGEKVYLCNQDEN
CCCCCEEEEECCCCC		19.3328152594
843PhosphorylationEKVYLCNQDENHKHA
CEEEEECCCCCCCCC		59.4024719451
843 (in isoform 2)Phosphorylation-59.4024719451
853PhosphorylationNHKHAQDYVLTYNYE
CCCCCCCEEEEEEEC		5.8127259358
856PhosphorylationHAQDYVLTYNYEGRG
CCCCEEEEEEECCCC		10.3229978859
857PhosphorylationAQDYVLTYNYEGRGS
CCCEEEEEEECCCCC		16.1629978859
859PhosphorylationDYVLTYNYEGRGSVA
CEEEEEEECCCCCEE		14.8929978859
864PhosphorylationYNYEGRGSVAGSVGC
EEECCCCCEECCEEE		13.8723927012
868PhosphorylationGRGSVAGSVGCCSER
CCCCEECCEEECCCC		12.9530278072
873PhosphorylationAGSVGCCSERQEEDG
ECCEEECCCCCCCCC		39.6320031617
890UbiquitinationFLDNLEPKFRTLAEA
HHHHCCHHHHHHHHH		37.802189047
890 (in isoform 1)Ubiquitination-37.8021890473
900UbiquitinationTLAEACMKR------
HHHHHHHCC------		55.64-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DSC2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DSC2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DSC2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DSG1_HUMANDSG1physical
9443898
PLAK_HUMANJUPphysical
9443898
DSG2_HUMANDSG2physical
11853539
Drug and Disease Associations
Kegg Disease
H00293 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
OMIM Disease
610476Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DSC2_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry.";
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.;
J. Proteome Res. 5:1493-1503(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-392 AND ASN-629, AND MASSSPECTROMETRY.
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-546, AND MASSSPECTROMETRY.

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